{ "uniprot_canonical_ac": "A5PLK6-1", "sequence": { "length": 1076, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK" }, "uniprot_id": "RGSL_HUMAN", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5PLK6", "id": "A5PLK6", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Regulator of G-protein signaling protein-like" }, "publication": [ { "title": "Chromosome 1q25.3 copy number alterations in primary breast cancers detected by multiplex ligation-dependent probe amplification and allelic imbalance assays and its comparison with fluorescent in situ hybridization assays.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23248035", "journal": "Cellular oncology (Dordrecht)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ], "authors": "Wiechec E, Overgaard J, Kjeldsen E, Hansen LL", "date": "2013", "pmid": "23248035" }, { "title": "High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21135262", "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ], "authors": "Wiechec E, Wiuf C, Overgaard J, Hansen LL", "date": "2011", "pmid": "21135262" }, { "title": "Intermediate phenotypes identify divergent pathways to Alzheimer's disease.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20574532", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ], "authors": "Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL", "date": "2010", "pmid": "20574532" }, { "title": "A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18521847", "journal": "Genes, chromosomes & cancer", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ], "authors": "Wiechec E, Overgaard J, Hansen LL", "date": "2008", "pmid": "18521847" }, { "title": "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11230166", "journal": "Genome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5PLK6/publications", "id": "A5PLK6", "database": "UniProtKB" } ], "authors": "Ansorge W., Bauersachs S., Beyer A., Bloecker H., Blum H., Boecher M., Duesterhoeft A., Gassenhuber J., Glassl S., Heubner D., Klein M., Koehrer K., Korn B., Lauber J., Mewes H.-W., Obermaier B., Ottenwaelder B., Poustka A., Strack N., Tampe J., Wambutt R., Weil B., Wellenreuther R., Wiemann S.", "date": "2001", "pmid": "11230166" } ], "glycosylation": [], "mutation": [ { "start_pos": 8, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0108", "annotation": "Somatic mutation in Ovarian cancer (DOID:2394) with frequency of 1/93 (0.0108)", "sequence_org": "G", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "D", "subjects_tested": "93", "end_pos": 8, "type": "Point mutation" }, { "start_pos": 256, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Breast cancer (DOID:1612) with frequency of 1/50 (0.0200)", "sequence_org": "W", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "C", "subjects_tested": "50", "end_pos": 256, "type": "Point mutation" }, { "start_pos": 256, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0152", "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", "sequence_org": "W", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "C", "subjects_tested": "66", "end_pos": 256, "type": "Point mutation" }, { "start_pos": 286, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0106", "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", "sequence_org": "E", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "*", "subjects_tested": "94", "end_pos": 286, "type": "Point mutation" }, { "start_pos": 420, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0108", "annotation": "Somatic mutation in Ovarian cancer (DOID:2394) with frequency of 1/93 (0.0108)", "sequence_org": "G", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "W", "subjects_tested": "93", "end_pos": 420, "type": "Point mutation" }, { "start_pos": 501, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0400", "annotation": "Somatic mutation in Prostate cancer (DOID:10283) with frequency of 1/25 (0.0400)", "sequence_org": "N", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "Prostate cancer" }, "sequence_mut": "K", "subjects_tested": "25", "end_pos": 501, "type": "Point mutation" }, { "start_pos": 641, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", "sequence_org": "M", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "I", "subjects_tested": "50", "end_pos": 641, "type": "Point mutation" }, { "start_pos": 683, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Breast cancer (DOID:1612) with frequency of 1/50 (0.0200)", "sequence_org": "I", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 683, "type": "Point mutation" }, { "start_pos": 709, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0139", "annotation": "Somatic mutation in Breast cancer (DOID:1612) with frequency of 1/72 (0.0139)", "sequence_org": "E", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "G", "subjects_tested": "72", "end_pos": 709, "type": "Point mutation" }, { "start_pos": 763, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", "sequence_org": "V", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 763, "type": "Point mutation" }, { "start_pos": 788, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0152", "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", "sequence_org": "Q", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "K", "subjects_tested": "66", "end_pos": 788, "type": "Point mutation" }, { "start_pos": 853, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0222", "annotation": "Somatic mutation in Kidney cancer (DOID:263) with frequency of 1/45 (0.0222)", "sequence_org": "A", "disease": { "doid": "263", "url": "http://disease-ontology.org/term/DOID:263", "icd10": "", "name": "Kidney cancer" }, "sequence_mut": "T", "subjects_tested": "45", "end_pos": 853, "type": "Point mutation" }, { "start_pos": 884, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0106", "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", "sequence_org": "F", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "L", "subjects_tested": "94", "end_pos": 884, "type": "Point mutation" }, { "start_pos": 958, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0106", "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "W", "subjects_tested": "94", "end_pos": 958, "type": "Point mutation" }, { "start_pos": 965, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0152", "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", "sequence_org": "I", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "V", "subjects_tested": "66", "end_pos": 965, "type": "Point mutation" }, { "start_pos": 1064, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLK6", "id": "A5PLK6", "database": "BioMuta" } ], "frequency": "0.0152", "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", "sequence_org": "V", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "F", "subjects_tested": "66", "end_pos": 1064, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5PLK6#A5PLK6-2", "isoform_ac": "A5PLK6-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 599, "sequence": "MLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A0U1RQD8-1", "isoform_ac": "A0A0U1RQD8-1", "locus": { "end_pos": 182473643, "start_pos": 182473885, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000634758", "id": "ENST00000634758", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000488942", "id": "ENSP00000488942", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 81, "sequence": "MQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQL" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A5PLK6-3", "isoform_ac": "A5PLK6-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 500, "sequence": "MSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A0U1RRN0-1", "isoform_ac": "A0A0U1RRN0-1", "locus": { "end_pos": 182471287, "start_pos": 182472406, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000634723", "id": "ENST00000634723", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489611", "id": "ENSP00000489611", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 37, "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEEL" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A5PLK6-4", "isoform_ac": "A5PLK6-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 402, "sequence": "MSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKR" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A0U1RRA3-1", "isoform_ac": "A0A0U1RRA3-1", "locus": { "end_pos": 182450166, "start_pos": 182458347, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000635407", "id": "ENST00000635407", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489421", "id": "ENSP00000489421", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 46, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPLCFAGFWSDTILYC" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A5PLK6-5", "isoform_ac": "A5PLK6-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 472, "sequence": "MLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVLFLEGNPLLLTV" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#H3BRN5-1", "isoform_ac": "H3BRN5-1", "locus": { "end_pos": 182450166, "start_pos": 182488312, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000422241", "id": "ENST00000422241", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000456332", "id": "ENSP00000456332", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 154, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGEARVSLLKSNWWWCWRDSQEDDEIGSTRNLFPHLDNNCTGRICMICSVPGMMSF" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A5PLK6-6", "isoform_ac": "A5PLK6-6", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 539, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGAKMMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTVGRTLG" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#H3BNQ0-1", "isoform_ac": "H3BNQ0-1", "locus": { "end_pos": 182474522, "start_pos": 182493024, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000415960", "id": "ENST00000415960", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454954", "id": "ENSP00000454954", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 29, "sequence": "AQKEICKMLSPWYDEFLDEEDYWFLLFTT" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A5PLK6-1", "isoform_ac": "A5PLK6-1", "locus": { "end_pos": 182450166, "start_pos": 182556054, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000294854", "id": "ENST00000294854", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000457748", "id": "ENSP00000457748", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 1076, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#H3BNS3-1", "isoform_ac": "H3BNS3-1", "locus": { "end_pos": 182471287, "start_pos": 182471373, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000447374", "id": "ENST00000447374", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454981", "id": "ENSP00000454981", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 29, "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYL" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A0U1RRF3-1", "isoform_ac": "A0A0U1RRF3-1", "locus": { "end_pos": 182471287, "start_pos": 182471379, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000634626", "id": "ENST00000634626", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489498", "id": "ENSP00000489498", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 31, "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYLTG" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#H3BVE8-1", "isoform_ac": "H3BVE8-1", "locus": { "end_pos": 182450166, "start_pos": 182488301, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000416676", "id": "ENST00000416676", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000458086", "id": "ENSP00000458086", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 160, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNINAQSLV" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#H3BU64-1", "isoform_ac": "H3BU64-1", "locus": { "end_pos": 182450166, "start_pos": 182551138, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000443996", "id": "ENST00000443996", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000457491", "id": "ENSP00000457491", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 984, "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGAKMMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVLFLEGNPLLLTV" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A0U1RRG0-1", "isoform_ac": "A0A0U1RRG0-1", "locus": { "end_pos": 182553470, "start_pos": 182560310, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000634801", "id": "ENST00000634801", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489508", "id": "ENSP00000489508", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 57, "sequence": "XRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGNLIQPIQTKG" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A0U1RRF6-1", "isoform_ac": "A0A0U1RRF6-1", "locus": { "end_pos": 182472452, "start_pos": 182473966, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000634679", "id": "ENST00000634679", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489502", "id": "ENSP00000489502", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 166, "sequence": "MDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQ" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#H3BNR3-1", "isoform_ac": "H3BNR3-1", "locus": { "end_pos": 182471287, "start_pos": 182472487, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000437548", "id": "ENST00000437548", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454969", "id": "ENSP00000454969", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 64, "sequence": "MMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSAGEELVDFWILAENILSIDEMDLEVRDYYLSL" } }, { "url": "https://www.uniprot.org/uniprot/A5PLK6#A0A3B3ISC9-1", "isoform_ac": "A0A3B3ISC9-1", "locus": { "end_pos": 182488285, "start_pos": 182530361, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000648414", "id": "ENST00000648414", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000497245", "id": "ENSP00000497245", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 270, "sequence": "MLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:353299", "resource": "KEGG Pathway", "id": "hsa:353299", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597", "resource": "Reactome", "id": "R-HSA-418597", "name": "G alpha (z) signalling events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594", "resource": "Reactome", "id": "R-HSA-418594", "name": "G alpha (i) signalling events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416476", "resource": "Reactome", "id": "R-HSA-416476", "name": "G alpha (q) signalling events" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "annotation": "Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "annotation": "Missense mutations in RGSL1 gene is associated with breast cancer.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "annotation": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "annotation": "A detailed mapping of the breakpoints revealed intragenic microdeletions affecting the coding regions of RGSL2, RGSL1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "id": "NP_001131141.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M608-1", "protein_name": "RGS domain-containing protein", "sequence": { "length": 1073, "sequence": "MSNAEIICSTNLIILLEDETFADFFNTFLSLPVFGQTPFYNVELSQWSLWPEIPYDLITKYKGLLTWLEKYRLPFFCKTNLCFYYILCQELISFVKSPEGGEELLDFWVLAEKILSIDETDEYLKDYYLSLLLVLKATHLQEGSRVVTLCNMDIKSLLNLSIWHPNQSTTRREILSHMQKVALFKIQSYWLPNFYTHAKMTMANEEACHGLLQEYETRLCSVCCTHAGGLPLNMSIKKSHRSQKKYSSKKAKKKMWHLNNPIFWPLETDPKPEVPTKAPEEMSLPERVVLQKPSLGEDSSKETVVHPLCKDLQNAKKPIVKKKSKIQLHMEGLLETTFSNHLRTSTPMINHAAPLVVKKSLKRSLSFGYTHWALCADACAGSPFRYHLKKMNLKAEVQLLDLWQDLQHFVSVLMTNRQNGNALFRHVLGNRICELYLNEQIGPPLPLKPQTLQGLKKLLPSGEVNPWIPKAQREICKMLSSRYDEFRLEGTLWVVEGFRLKQRFIKARWYKESQLTERRHVSFIYSGVQPLAVNAAWLTATRKSVVLFRWQKVGYELAKGGSLSIELTRVKCLQDTSKMSFKDLSFKNPKLAIEKMSEDYKIYCERVPPTDFTVEIIKQPRVSYSQRKISFAKRSVIRKPSMRPRNMTEILLNNAHLEYFREFLKDRKSENPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPPDKILQCDAPFVKEVVNRHITTPPIAELQGIIMECVEEKWFKEYQDLFPPRPVEVEPVETHVVPRKPSKTITTHLHDSQKRGWIKMISFIKSFCKYRRFVTNAKNLQELTDFIYLEMYNNKENFSSSPTPSARHTPIYPSARNTEPENGEIALVKRRIFGHRIITINFAVNDIYFFSEMEKFNDLVTSAHMLQVNKAYNENDIVLMRSKLNIILKLYLISDLPPKLRVNISESQKDIIFSAITEGHLDRTIFHGAIMSVFPVVMYFWKRFCSWKTRSYIESLGRIEDGRNPPKSVYKYPPWSGGDHTVLRFSLLRGIEWFRPQHPRDVLTNSLQNYQKYPKKKKRKNNHAKSRTEVDDSLSASQY" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A5PLK6/", "id": "A5PLK6", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "H3BL40-1", "protein_name": "", "sequence": { "length": 1073, "sequence": "MSNADIICSTNLIILLEDETFADFFNTFLSLPVFGQTPFYNVEKSQWSLWPEVPYDLIAKYKGLLTWLEKYRLPFFCKTNLCFYYILSQELVSFLKSPEGGEELLDFWILAEKILSIDETDKYLKDYYLSLLLVLKATHLQEGSRVVTLCNMDIKSLLNLSIWHPNQSTTRREILSHMQKVALFKIQSYWLPNFYTHAKMTMANEEACHGLMQEYETRLYSVCCAHAGGLPLNMSIKKSRHSQKKYSSKKAKKKIWHLNNPILWPLETDAKPEVPTKPQEELSLPERVVLQKTSLGEDSSKETIIHSLCKDLQNAKKPIVKKKSKIQLHMEGFLETAFTNHLRSSTPIINHAAPLVVKKSLKRSLSFGYTHWALCADACAGSPFRFHLKKMNLKVEVQLLDLWQDLQHFISVLMNNRQNGNALFRHMLGNRICELYLNEQIGPPLPLKPQTLQGLKKLLPSGEVNPWIPKAQREICKVLSPWYDEFLMEEDYWFLIFTTQTRFAKARWHKRETISKEEHILLYKRLQESLVLSQALASMQEIDSMQWQKVATENLRQGGSLQVELTTPVFLQDISKMSFKDLSFKNPKLAIEKMSEDYKIYCEKVPPTAFTVEIIRQPKYSYSQRKTSFVKKSVVRKPSMRPRNLTEVLLNNAHLEYFKEFLKDRKSESPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPAEEILQCDAPFIKEIANVRHITTTTLLMLQGYVMKSVEEKWFKEYQDLFPPRSVEFEFVEAQAVPRKPSKSTTHLHDSQKRGWIKMIAFIKSFCNYRRFIADANNRQELADFIYLEMFNNKENFSTSPATSARHTPVNLSARNAEQENGDTVLVKRRIFGHRIITINFAVNDMYLFSEMERFNDLVSSAHMLQINRAYNENDIILMRSKLNIIVKLYLVSDLPPKLKVNISESQKDIIISAITEGHLDRTIFHGAIMSIFPVIMYFWKRFCNWKATRSYVEYLGKKFEDGRNPPKSVYKYPPWSGGEHTVLRFSLLRGVEWFRPQHPRDAVPSSLQPYQKYPTTKKRRSNQAKAKADMDGPLTLSQY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/129962", "id": "129962", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131141.1", "ac": "NP_001131141.1", "name": "regulator of G-protein signaling protein-like isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5PLK6", "id": "A5PLK6", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 1, "name": "Cellular Component" } ] }, "site_annotation": [ { "end_pos": 161, "annotation": "n_glycosylation_sequon", "start_pos": 159 }, { "end_pos": 168, "annotation": "n_glycosylation_sequon", "start_pos": 166 }, { "end_pos": 235, "annotation": "n_glycosylation_sequon", "start_pos": 233 }, { "end_pos": 352, "annotation": "n_glycosylation_sequon", "start_pos": 350 }, { "end_pos": 647, "annotation": "n_glycosylation_sequon", "start_pos": 645 }, { "end_pos": 834, "annotation": "n_glycosylation_sequon", "start_pos": 832 }, { "end_pos": 840, "annotation": "n_glycosylation_sequon", "start_pos": 838 }, { "end_pos": 1045, "annotation": "n_glycosylation_sequon", "start_pos": 1043 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:353299", "id": "hsa:353299", "database": "KEGG Pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418597", "id": "R-HSA-418597", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418594", "id": "R-HSA-418594", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416476", "id": "R-HSA-416476", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=18636", "id": "18636", "database": "HGNC" }, { "url": "https://omabrowser.org/oma/group/FTTQNKF/", "id": "FTTQNKF", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "id": "IPR016137", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "id": "IPR036305", "database": "InterPro" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGSL1", "id": "RGSL1", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/353299", "id": "353299", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00615", "id": "PF00615", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5PLK6", "id": "PR_A5PLK6", "database": "PRO" }, { "url": "https://www.nextprot.org/entry/NX_A5PLK6", "id": "NX_A5PLK6", "database": "neXtProt" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A5PLK6*", "id": "A5PLK6", "database": "IntAct" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLK6", "id": "A5PLK6", "database": "BioXpress" } ] } ], "uniprot_ac": "A5PLK6", "disease": [], "mass": { "monoisotopic_mass": 125688.0, "chemical_mass": 125688.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000121446", "id": "ENSG00000121446", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=18636", "name": "RGSL1", "locus": { "end_pos": 182560599, "start_pos": 182409192, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000121446", "id": "ENSG00000121446", "database": "Ensembl Gene" } ] } } ] }