{ "uniprot_canonical_ac": "A2RT31-1", "sequence": { "length": 317, "sequence": "MEGKNQTAPSEFIILGFDHLNELQYLLFTIFFLTYICTLGGNVFIIVVTIADSHLHTPMYYFLGNLALIDICYTTTNVPQMMVHLLSEKKIISYGGCVTQLFAFIFFVGSECLLLAAMAYDRYIAICKPLRYSFIMNKALCSWLAASCWTGGFLNSVLHTVLTFHLPFCGNNQINYFFCDIPPLLILSCGDTSLNELALLSIGILIGWTPFLCVILSYLYIISTILRIRSSEGRHKAFSTCASHLLIVILYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPVIYTLRNKDIKEAVKAIGRKWQPPVFSSDI" }, "uniprot_id": "A2RT31_MOUSE", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Olfactory receptor" }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RT31#A2RT31-1", "isoform_ac": "A2RT31-1", "locus": { "end_pos": 37498653, "start_pos": 37499603, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000216472", "id": "ENSMUST00000216472", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000149213", "id": "ENSMUSP00000149213", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 317, "sequence": "MEGKNQTAPSEFIILGFDHLNELQYLLFTIFFLTYICTLGGNVFIIVVTIADSHLHTPMYYFLGNLALIDICYTTTNVPQMMVHLLSEKKIISYGGCVTQLFAFIFFVGSECLLLAAMAYDRYIAICKPLRYSFIMNKALCSWLAASCWTGGFLNSVLHTVLTFHLPFCGNNQINYFFCDIPPLLILSCGDTSLNELALLSIGILIGWTPFLCVILSYLYIISTILRIRSSEGRHKAFSTCASHLLIVILYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPVIYTLRNKDIKEAVKAIGRKWQPPVFSSDI" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:258325", "resource": "KEGG Pathway", "id": "mmu:258325", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381753", "resource": "Reactome", "id": "R-MMU-381753", "name": "Olfactory Signaling Pathway" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666440.2", "annotation": "Olfr110/111 and Olfr544 proteins are mainly expressed by neurons in cortical and hippocampal regions and, to a lesser extent, by glia and endothelial cells. expression of the mRNA encoding for Olfr110/111 tends to increase with age in both the cortex and hippocampus of wild-type and transgenic mice. Moreover, Olfr110/111 transcript expression is markedly impaired in the brain of Alzheimer's disease-like mice.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666440.2", "id": "NP_666440.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9UGF6-1", "protein_name": "Olfactory receptor 5V1", "sequence": { "length": 321, "sequence": "MERKNQTAITEFIILGFSNLNELQFLLFTIFFLTYFCTLGGNILIILTTVTDPHLHTPMYYFLGNLAFIDICYTTSNVPQMMVHLLSKKKSISYVGCVVQLFAFVFFVGSECLLLAAMAYDRYIAICNPLRYSVILSKVLCNQLAASCWAAGFLNSVVHTVLTFCLPFCGNNQINYFFCDIPPLLILSCGNTSVNELALLSTGVFIGWTPFLCIVLSYICIISTILRIQSSEGRRKAFSTCASHLAIVFLFYGSAIFTYVRPISTYSLKKDRLVSVLYSVVTPMLNPIIYTLRNKDIKEAVKTIGSKWQPPISSLDSKLTY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/73968", "id": "73968", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q7TRK1-1", "protein_name": "Olfactory receptor", "sequence": { "length": 317, "sequence": "MEGKNQTAPSEFIILGFDHLNELQYLLFTIFFLTYICTLGGNVFIIVVTIADSHLHTPMYYFLGNLALIDICYTTTNVPQMMVHLLSEKKIISYGGCVTQLFAFIFFVGSECLLLAAMAYDRYIAICKPLRYSFIMNKALCSWLAASCWTCGFLNSVLHTVLTFHLPFCGNNQINYFFCDIPPLLILSCGDTSLNELALLSIGILIGWTPFLCIILSYLYIISTILRIRSSEGRQKAFSTCASHLLIVILYYGSAIFTYVRPISSYSLEKDRLISVLYSVFTPMLNPIIYALRNKDIKEAVKAIGRKWQPPVFSSDM" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/73968", "id": "73968", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666440.2", "ac": "NP_666440.2", "name": "olfactory receptor 110", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "G protein-coupled receptor activity", "id": "GO:0004930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "olfactory receptor activity", "id": "GO:0004984" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT31", "id": "A2RT31", "database": "UniProtKB" } ], "name": "sensory perception of smell", "id": "GO:0007608" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 7, "annotation": "n_glycosylation_sequon", "start_pos": 5 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:258325", "id": "mmu:258325", "database": "KEGG Pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381753", "id": "R-MMU-381753", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000090894", "id": "ENSMUSG00000090894", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:2177493", "id": "2177493", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/SNVPQMM/", "id": "SNVPQMM", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "id": "IPR000276", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "id": "IPR017452", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "id": "IPR000725", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/258325", "id": "258325", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF13853", "id": "PF13853", "database": "Pfam" } ], "expression_disease": [], "uniprot_ac": "A2RT31", "disease": [], "mass": { "monoisotopic_mass": 35760.0, "chemical_mass": 35760.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:2177493", "name": "Olfr110", "locus": { "end_pos": 37500207, "start_pos": 37492468, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000090894", "id": "ENSMUSG00000090894", "database": "Ensembl Gene" } ] } } ] }