{ "uniprot_canonical_ac": "A2AM29-1", "sequence": { "length": 569, "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSGQQDKKAPSKRPPASDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSMLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" }, "uniprot_id": "AF9_MOUSE", "enzyme_annotation": [], "alternativenames": [ { "full": "Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Protein AF-9" }, "publication": [ { "title": "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11439343", "journal": "Oncogene", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29/publications", "id": "A2AM29", "database": "UniProtKB" } ], "authors": "Gould G.C.D., Hemenway C.S., de Erkenez A.C.", "date": "2001", "pmid": "11439343" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AM29#A2AM29-1", "isoform_ac": "A2AM29-1", "locus": { "end_pos": 87774018, "start_pos": 88033095, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000078090", "id": "ENSMUST00000078090", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000077232", "id": "ENSMUSP00000077232", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 569, "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSGQQDKKAPSKRPPASDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSMLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" } }, { "url": "https://www.uniprot.org/uniprot/A2AM29#Q3UIA3-1", "isoform_ac": "Q3UIA3-1", "locus": { "end_pos": 87774018, "start_pos": 87791965, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000149357", "id": "ENSMUST00000149357", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000128366", "id": "ENSMUSP00000128366", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 162, "sequence": "MKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" } }, { "url": "https://www.uniprot.org/uniprot/A2AM29#E9PXP8-1", "isoform_ac": "E9PXP8-1", "locus": { "end_pos": 87774018, "start_pos": 87782319, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000148059", "id": "ENSMUST00000148059", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000131095", "id": "ENSMUSP00000131095", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 54, "sequence": "MTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" } }, { "url": "https://www.uniprot.org/uniprot/A2AM29#E9Q3B8-1", "isoform_ac": "E9Q3B8-1", "locus": { "end_pos": 88011673, "start_pos": 88032639, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000142454", "id": "ENSMUST00000142454", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000127376", "id": "ENSMUSP00000127376", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 73, "sequence": "MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRAWTEWRWLRSGC" } }, { "url": "https://www.uniprot.org/uniprot/A2AM29#Q9D2P1-1", "isoform_ac": "Q9D2P1-1", "locus": { "end_pos": 87774018, "start_pos": 87791965, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000126353", "id": "ENSMUST00000126353", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000129523", "id": "ENSMUSP00000129523", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 138, "sequence": "MKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:70122", "resource": "KEGG Pathway", "id": "mmu:70122", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112382", "resource": "Reactome", "id": "R-MMU-112382", "name": "Formation of RNA Pol II elongation complex" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75955", "resource": "Reactome", "id": "R-MMU-75955", "name": "RNA Polymerase II Transcription Elongation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-674695", "resource": "Reactome", "id": "R-MMU-674695", "name": "RNA Polymerase II Pre-transcription Events" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AM29#function", "annotation": "Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29#function", "id": "A2AM29", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "annotation": "Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "id": "NP_081602.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "annotation": "YEATS domain of AF9 directly links histone crotonylation to active transcription.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "id": "NP_081602.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "annotation": "Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "id": "NP_081602.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "annotation": "Af9 gene is required for normal embryogenesis in mice by controlling pattern formation, apparently via control of Hox gene regulation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "id": "NP_081602.3", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2QC34-1", "protein_name": "", "sequence": { "length": 500, "sequence": "MIVFMKRSSKPLLPSHHCLSVLQEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSAQQDKKAPSKRPPVSDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AM29/", "id": "A2AM29", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "P42568-1", "protein_name": "Protein AF-9", "sequence": { "length": 568, "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AM29/", "id": "A2AM29", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/37933", "id": "37933", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081602.3", "ac": "NP_081602.3", "name": "protein AF-9 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "histone binding", "id": "GO:0042393" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070577", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "lysine-acetylated histone binding", "id": "GO:0070577" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140030", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "modification-dependent protein binding", "id": "GO:0140030" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "transcription elongation factor complex", "id": "GO:0008023" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "chromosome", "id": "GO:0005694" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "anterior/posterior pattern specification", "id": "GO:0009952" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "positive regulation of Wnt signaling pathway, planar cell polarity pathway", "id": "GO:2000096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007379", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AM29", "id": "A2AM29", "database": "UniProtKB" } ], "name": "segment specification", "id": "GO:0007379" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 145, "annotation": "n_glycosylation_sequon", "start_pos": 143 }, { "end_pos": 228, "annotation": "n_glycosylation_sequon", "start_pos": 226 }, { "end_pos": 365, "annotation": "n_glycosylation_sequon", "start_pos": 363 }, { "end_pos": 372, "annotation": "n_glycosylation_sequon", "start_pos": 370 }, { "end_pos": 430, "annotation": "n_glycosylation_sequon", "start_pos": 428 }, { "end_pos": 543, "annotation": "n_glycosylation_sequon", "start_pos": 541 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:70122", "id": "mmu:70122", "database": "KEGG Pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112382", "id": "R-MMU-112382", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75955", "id": "R-MMU-75955", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-674695", "id": "R-MMU-674695", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028496", "id": "ENSMUSG00000028496", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:1917372", "id": "1917372", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/PNRSVHT/", "id": "PNRSVHT", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038704", "id": "IPR038704", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005033", "id": "IPR005033", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040930", "id": "IPR040930", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/70122", "id": "70122", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF03366", "id": "PF03366", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17793", "id": "PF17793", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23195", "id": "PTHR23195", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AM29", "id": "PR_A2AM29", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AM29*", "id": "A2AM29", "database": "IntAct" } ], "expression_disease": [], "uniprot_ac": "A2AM29", "disease": [], "mass": { "monoisotopic_mass": 63375.0, "chemical_mass": 63375.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:1917372", "name": "Mllt3", "locus": { "end_pos": 87769925, "start_pos": 88033364, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000028496", "id": "ENSMUSG00000028496", "database": "Ensembl Gene" } ] } } ] }