{ "uniprot_canonical_ac": "A2AEV7-1", "sequence": { "length": 629, "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG" }, "uniprot_id": "CC120_MOUSE", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Coiled-coil domain-containing protein 120" }, "publication": [ { "title": "Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28422092", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7/publications", "id": "A2AEV7", "database": "UniProtKB" } ], "authors": "Chen J., Wang S., Zhang D., Xia Y., He R., Huang N., Teng J., Bao Y.", "date": "2017", "pmid": "28422092" }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7/publications", "id": "A2AEV7", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014", "pmid": "24129315" }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7/publications", "id": "A2AEV7", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007", "pmid": "17242355" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7#A2AEV7-1", "isoform_ac": "A2AEV7-1", "locus": { "end_pos": 7733159, "start_pos": 7738210, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000033490", "id": "ENSMUST00000033490", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000033490", "id": "ENSMUSP00000033490", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 629, "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG" } }, { "url": "https://www.uniprot.org/uniprot/A2AEV7#A0A286YDD1-1", "isoform_ac": "A0A286YDD1-1", "locus": { "end_pos": 7732621, "start_pos": 7733904, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000224502", "id": "ENSMUST00000224502", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000153379", "id": "ENSMUSP00000153379", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 278, "sequence": "XAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYTDFLYPPELSARLSDLTLEGEPSSSSDTQTPGTLV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:54648", "resource": "KEGG Pathway", "id": "mmu:54648", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7#function", "annotation": "Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7#function", "id": "A2AEV7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAB5-1", "protein_name": "", "sequence": { "length": 658, "sequence": "MEVKGQLINSPTFNAPAALFGEAAPQVKSDRLRGLLDRQQALQETLRLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHSNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSSGAPVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHPRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGPPRLPPVCGDFLLDYSLDRGLPRGSGGAGWGDLLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNSRAIRSKPCGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYTDFLYPPELSARLSDLTLEGEQSSSSDTQTPGTLV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14146", "id": "14146", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AEV7/", "id": "A2AEV7", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q96HB5-1", "protein_name": "Coiled-coil domain-containing protein 120", "sequence": { "length": 630, "sequence": "MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGAGPQLCKPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEALLVDRAAGGGAGSPPAPLAPSASGPPVCKSSEVLYERPQPTPAFSSRTAGPPDPPRAARPSSAAPASRGAPRLPPVCGDFLLDYSLDRGLPRSGGGTGWGELPPAAEVPGPLSRRDGLLTMLPGPPPVYAADSNSPLLRTKDPHTRATRTKPCGLPPEAAEGPEVHPNPLLWMPPPTRIPSAGERSGHKNLALEGLRDWYIRNSGLAAGPQRRPVLPSVGPPHPPFLHARCYEVGQALYGAPSQAPLPHSRSFTAPPVSGRYGGCFY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14146", "id": "14146", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085.2", "ac": "NP_997085.2", "name": "coiled-coil domain-containing protein 120", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "centriolar subdistal appendage", "id": "GO:0120103" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "protein localization", "id": "GO:0008104" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034454", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "microtubule anchoring at centrosome", "id": "GO:0034454" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 358, "annotation": "n_glycosylation_sequon", "start_pos": 356 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:54648", "id": "mmu:54648", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031150", "id": "ENSMUSG00000031150", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:1859619", "id": "1859619", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/WGKQQRM/", "id": "WGKQQRM", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021774", "id": "IPR021774", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039108", "id": "IPR039108", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/54648", "id": "54648", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF11819", "id": "PF11819", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16093:SF5", "id": "PTHR16093:SF5", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AEV7", "id": "PR_A2AEV7", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A2AEV7", "disease": [], "mass": { "monoisotopic_mass": 67407.0, "chemical_mass": 67407.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:1859619", "name": "Ccdc120", "locus": { "end_pos": 7731714, "start_pos": 7750905, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000031150", "id": "ENSMUSG00000031150", "database": "Ensembl Gene" } ] } } ] }