{
    "uniprot_canonical_ac": "A6NCL7-1", 
    "sequence": {
        "length": 494, 
        "sequence": "MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLLRAACANNVGLLRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALITAAQAGHAIITNYLLNYFPGLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHARDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKNCLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKRRLAVQEILAARAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALGSRGPAAPAPRKASLLPLQRLRRRSVRPGVVVPRVRVSKAPAPTFQPERPARKGSTKDSGHLQIPKWRYKEAKEEKRKAEEAEKKRQAEAQKERRTAPWKKRT"
    }, 
    "uniprot_id": "AN33B_HUMAN", 
    "enzyme_annotation": [], 
    "alternativenames": [], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Ankyrin repeat domain-containing protein 33B"
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 51, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1429", 
            "annotation": "Somatic mutation in Hematologic cancer (DOID:2531) with frequency of 1/7 (0.1429)", 
            "sequence_org": "S", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "N", 
            "subjects_tested": "7", 
            "end_pos": 51, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 173, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "50", 
            "end_pos": 173, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 202, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0106", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", 
            "sequence_org": "R", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "94", 
            "end_pos": 202, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 284, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "T", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "K", 
            "subjects_tested": "50", 
            "end_pos": 284, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 297, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0400", 
            "annotation": "Somatic mutation in Prostate cancer (DOID:10283) with frequency of 1/25 (0.0400)", 
            "sequence_org": "R", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "Prostate cancer"
            }, 
            "sequence_mut": "Q", 
            "subjects_tested": "25", 
            "end_pos": 297, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 306, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "D", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "50", 
            "end_pos": 306, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 370, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0263", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/38 (0.0263)", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "W", 
            "subjects_tested": "38", 
            "end_pos": 370, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 378, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0152", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", 
            "sequence_org": "S", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "66", 
            "end_pos": 378, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 398, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0152", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "66", 
            "end_pos": 398, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 417, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "V", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "M", 
            "subjects_tested": "50", 
            "end_pos": 417, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 429, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "S", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "50", 
            "end_pos": 429, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 443, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0152", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "66", 
            "end_pos": 443, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 454, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "Q", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "50", 
            "end_pos": 454, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 490, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCL7", 
                    "id": "A6NCL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0139", 
            "annotation": "Somatic mutation in Breast cancer (DOID:1612) with frequency of 1/72 (0.0139)", 
            "sequence_org": "W", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "72", 
            "end_pos": 490, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NCL7#A6NCL7-1", 
            "isoform_ac": "A6NCL7-1", 
            "locus": {
                "end_pos": 10564468, 
                "start_pos": 10650110, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000296657", 
                        "id": "ENST00000296657", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000296657", 
                        "id": "ENSP00000296657", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 494, 
                "sequence": "MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLLRAACANNVGLLRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALITAAQAGHAIITNYLLNYFPGLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHARDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKNCLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKRRLAVQEILAARAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALGSRGPAAPAPRKASLLPLQRLRRRSVRPGVVVPRVRVSKAPAPTFQPERPARKGSTKDSGHLQIPKWRYKEAKEEKRKAEEAEKKRQAEAQKERRTAPWKKRT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NCL7#D6R912-1", 
            "isoform_ac": "D6R912-1", 
            "locus": {
                "end_pos": 10564468, 
                "start_pos": 10624822, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000504806", 
                        "id": "ENST00000504806", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000422195", 
                        "id": "ENSP00000422195", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 198, 
                "sequence": "MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLLRAACANNVGLLRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALITAAQAGAAPVPMGIVSLDTGSQSCASGVSITWAGSCEH"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:651746", 
            "resource": "KEGG Pathway", 
            "id": "hsa:651746", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q3U0L2-1", 
            "protein_name": "Ankyrin repeat domain-containing protein 33B", 
            "sequence": {
                "length": 486, 
                "sequence": "MVLLAGPGPEGGGTRCLSPQSPTPPRSEQTGEDPADYEEYEDFSSLPDTRSIASDDSFYPPGGEEEYGSVSAESVPEGVPEAATLLRAACANDVGLLRALVRRGPSSEEVRETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALITAAQAGHVTITNYLLNYFPGLDLERRNIFGFTALMKAAMQGRTECVRALMMAGADVQARDPRRGLSPQEWAAYTGRAEAVRVIQRLMERPCPEQFGDKYKLELPLPAEAVLKKSGSKNCLQRFTAFLRSTLTSRSSGQSLEDGGVLDHMVRMTTSLYSPAVAVVCQTVCPENPPCVGKRRLAVQEILAARGNLNAQAQDSNKVECSEPQSQILETPRASSRSPKSPAASRSTPAPVTRKASLLPLQLLRRSSVRPGVVVPRVRISKAPAPTFQPERAASKGNTKDSIYLQIPKWRYKEAKEEKRKAEEAEKKRQAEAQKEKRAPRWRKRT"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12362", 
                    "id": "12362", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "D3ZTU7-1", 
            "protein_name": "", 
            "sequence": {
                "length": 481, 
                "sequence": "MVLLAGPGPEGGGTRCLSPQSPTPPRSVQTGDDPADYEEYEDFSSLPDTRSIASDDSFYPPGGEEECGSVCAESVPEGVPESATLLRAACANDVGLLRALVRRGPSSEEARETDRNGRTGLIIACYHGFVDTVVALAECPHIDVNWQDSEGNTALITAAQAGHATITNYLLNYFPGLDLERRNIFGFTALMKAAMQGRTECVRALMLAGADVQARDPRRGLSPQEWAAYTGRAEAVRVMQRLMERPCPEQFGDKYKLELPLPAETILKKAGSKNCLQRFTAFLRSTLTSRSGQSLEDGGVLDHMVRMTTSLYSPAVAVVCQTVCPENPPCVGKRRLAVQEILAARGNLDAQAQDSNNVELQSQILETPRASSRSPQSLGSGSTPAPVTRKASLLPLQLLRRSSVRPGVVVPRVRISKAPAPTFQPERAASKGNTKDSIYLQIPKWRYKEAKEEKRKAEEAEKKRQAEAQKERRAPRWRKRT"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A6NCL7/", 
                    "id": "A6NCL7", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/12362", 
                    "id": "12362", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157912.1", 
        "ac": "NP_001157912.1", 
        "name": "ankyrin repeat domain-containing protein 33B", 
        "summary": ""
    }, 
    "go_annotation": {}, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:651746", 
            "id": "hsa:651746", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
            "id": "ENSG00000164236", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=35240", 
            "id": "35240", 
            "database": "HGNC"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/CPEQFGE/", 
            "id": "CPEQFGE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", 
            "id": "IPR002110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", 
            "id": "IPR020683", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", 
            "id": "IPR036770", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ANKRD33B", 
            "id": "ANKRD33B", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/651746", 
            "id": "651746", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF12796", 
            "id": "PF12796", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6NCL7", 
            "id": "PR_A6NCL7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A6NCL7", 
            "id": "NX_A6NCL7", 
            "database": "neXtProt"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A6NCL7", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 53975.0, 
        "chemical_mass": 53975.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
                    "id": "ENSG00000164236", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
                    "id": "ENSG00000164236", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
                    "id": "ENSG00000164236", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
                    "id": "ENSG00000164236", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
                    "id": "ENSG00000164236", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164236", 
                    "id": "ENSG00000164236", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
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    ]
}