{
    "uniprot_canonical_ac": "A5X5Y0-1", 
    "sequence": {
        "length": 456, 
        "sequence": "MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT"
    }, 
    "uniprot_id": "5HT3E_HUMAN", 
    "enzyme_annotation": [], 
    "alternativenames": [
        {
            "full": "Serotonin receptor 3E", 
            "short": ""
        }
    ], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "5-hydroxytryptamine receptor 3E", 
        "short": "5-HT3E"
    }, 
    "publication": [
        {
            "title": "5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/23928294", 
            "journal": "European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lennertz L, Wagner M, Grabe HJ, Franke PE, Guttenthaler V, Rampacher F, Schulze-Rauschenbach S, Vogeley A, Benninghoff J, Ruhrmann S, Pukrop R, Klosterkotter J, Falkai P, Maier W, Mossner R", 
            "date": "2014", 
            "pmid": "23928294"
        }, 
        {
            "title": "Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21192076", 
            "journal": "The Journal of comparative neurology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kapeller J, Moller D, Lasitschka F, Autschbach F, Hovius R, Rappold G, Bruss M, Gershon MD, Niesler B", 
            "date": "2011", 
            "pmid": "21192076"
        }, 
        {
            "title": "Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20602613", 
            "journal": "Pharmacogenomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Hammer C, Fasching PA, Loehberg CR, Rauh C, Ekici AB, Jud SM, Bani MR, Beckmann MW, Strick R, Niesler B", 
            "date": "2010", 
            "pmid": "20602613"
        }, 
        {
            "title": "Central 5-HT receptors in cardiovascular control during stress.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18573276", 
            "journal": "Neuroscience and biobehavioral reviews", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Nalivaiko E, Sgoifo A", 
            "date": "2009", 
            "pmid": "18573276"
        }, 
        {
            "title": "Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/19012743", 
            "journal": "J. Neurochem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0/publications", 
                    "id": "A5X5Y0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Balmer G., Courtenay N., Gill C.H., Gunthorpe M.J., Holbrook J.D., Kelly F.M., Leyland R., Luck J., Modha S., Moore S.E., Rance K.H., Rhodes A., Sanger G.J., Spencer J.P., Trinh H., Yusaf S.P., Zebda N.", 
            "date": "2009", 
            "pmid": "19012743"
        }, 
        {
            "title": "First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18614545", 
            "journal": "Human molecular genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kapeller J, Houghton LA, Monnikes H, Walstab J, Moller D, Bonisch H, Burwinkel B, Autschbach F, Funke B, Lasitschka F, Gassler N, Fischer C, Whorwell PJ, Atkinson W, Fell C, Buchner KJ, Schmidtmann M, van der Voort I, Wisser AS, Berg T, Rappold G, Niesler B", 
            "date": "2008", 
            "pmid": "18614545"
        }, 
        {
            "title": "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17392525", 
            "journal": "Mol. Pharmacol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0/publications", 
                    "id": "A5X5Y0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Boenisch H., Bruess M., Combrink S., Goethert M., Kapeller J., Moeller D., Niesler B., Rappold G., Rietdorf J., Walstab J.", 
            "date": "2007", 
            "pmid": "17392525"
        }, 
        {
            "title": "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12801637", 
            "journal": "Gene", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0/publications", 
                    "id": "A5X5Y0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Frank B., Kapeller J., Niesler B., Rappold G.A.", 
            "date": "2003", 
            "pmid": "12801637"
        }, 
        {
            "title": "A cluster of novel serotonin receptor 3-like genes on human chromosome 3.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/14597179", 
            "journal": "Gene", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0/publications", 
                    "id": "A5X5Y0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Benjamin C.W., Fitzgerald L.R., Gotow L.F., Karnovsky A.M., McKinley D.D., Mills C.J., Piechan J.L., Roberds S.L., Ruble C.L., Schellin K.A.B., Slightom J.L.", 
            "date": "2003", 
            "pmid": "14597179"
        }
    ], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0#ptm_processing", 
                    "id": "A5X5Y0-1", 
                    "database": "UniProtKB"
                }
            ], 
            "relation": "attached", 
            "position": 175, 
            "glytoucan_ac": "GlcNAc...", 
            "type": "N-linked"
        }
    ], 
    "mutation": [
        {
            "start_pos": 160, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "S", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "end_pos": 160, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 176, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0108", 
            "annotation": "Somatic mutation in Ovarian cancer (DOID:2394) with frequency of 1/93 (0.0108)", 
            "sequence_org": "C", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "Y", 
            "subjects_tested": "93", 
            "end_pos": 176, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 261, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0106", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", 
            "sequence_org": "L", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "M", 
            "subjects_tested": "94", 
            "end_pos": 261, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 345, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "50", 
            "end_pos": 345, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 372, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "P", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "50", 
            "end_pos": 372, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#A5X5Y0-1", 
            "isoform_ac": "A5X5Y0-1", 
            "locus": {
                "end_pos": 184097530, 
                "start_pos": 184106690, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000415389", 
                        "id": "ENST00000415389", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000401444", 
                        "id": "ENSP00000401444", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 456, 
                "sequence": "MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#C9J420-1", 
            "isoform_ac": "C9J420-1", 
            "locus": {
                "end_pos": 184100631, 
                "start_pos": 184105394, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000431041", 
                        "id": "ENST00000431041", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000391254", 
                        "id": "ENSP00000391254", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 158, 
                "sequence": "MSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#A5X5Y0-2", 
            "isoform_ac": "A5X5Y0-2", 
            "locus": {
                "end_pos": 184097530, 
                "start_pos": 184106690, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000425359", 
                        "id": "ENST00000425359", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000401900", 
                        "id": "ENSP00000401900", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 441, 
                "sequence": "MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#A5X5Y0-3", 
            "isoform_ac": "A5X5Y0-3", 
            "locus": {
                "end_pos": 184100373, 
                "start_pos": 184106690, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000335304", 
                        "id": "ENST00000335304", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000335511", 
                        "id": "ENSP00000335511", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 471, 
                "sequence": "MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#A5X5Y0-4", 
            "isoform_ac": "A5X5Y0-4", 
            "locus": {
                "end_pos": 184100373, 
                "start_pos": 184106690, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000436361", 
                        "id": "ENST00000436361", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000395833", 
                        "id": "ENSP00000395833", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 456, 
                "sequence": "MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#A5X5Y0-6", 
            "isoform_ac": "A5X5Y0-6", 
            "locus": {
                "end_pos": 184100373, 
                "start_pos": 184106690, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000440596", 
                        "id": "ENST00000440596", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000406050", 
                        "id": "ENSP00000406050", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 482, 
                "sequence": "MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:285242", 
            "resource": "KEGG Pathway", 
            "id": "hsa:285242", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-112314", 
            "resource": "Reactome", 
            "id": "R-HSA-112314", 
            "name": "Neurotransmitter receptors and postsynaptic signal transmission"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A5X5Y0#function", 
            "annotation": "This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5X5Y0#function", 
                    "id": "A5X5Y0", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
            "annotation": "The HTR3E remained significant after correction for the number of variants investigated.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
            "annotation": "Data show that 5-HT3C, 5-HT3D, and 5-HT3E subunits are coexpressed with 5-HT3A in cell bodies of myenteric neurons, and that 5-HT3A and 5-HT3D were expressed in submucosal plexus of the human large intestine.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
            "annotation": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
            "annotation": "Data show that 5-HT3 receptors locat in the nucleus tractus silitarius contribute to stress-induced suppression of the baroreflex. Review article", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
            "annotation": "MicroRNA-510 target site of the 3'UTR of HTR3A and HTR3E are associated with the irritable bowel syndrome with diarrhea. GeneRIF: The binding site for miR-510 is solely located in the 3' UTR of the HTR3E gene. No predicted binding site for miR-510 exists in the 3' UTR of HTR3A.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
                    "id": "NP_001243542.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243542.1", 
        "ac": "NP_001243542.1", 
        "name": "5-hydroxytryptamine receptor 3E isoform d precursor", 
        "summary": "This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transmembrane signaling receptor activity", 
                        "id": "GO:0004888"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022850", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "serotonin-gated cation-selective channel activity", 
                        "id": "GO:0022850"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of plasma membrane", 
                        "id": "GO:0005887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "synapse", 
                        "id": "GO:0045202"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "neuron projection", 
                        "id": "GO:0043005"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "signal transduction", 
                        "id": "GO:0007165"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of membrane potential", 
                        "id": "GO:0042391"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chemical synaptic transmission", 
                        "id": "GO:0007268"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034220", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ion transmembrane transport", 
                        "id": "GO:0034220"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050877", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5X5Y0", 
                                "id": "A5X5Y0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nervous system process", 
                        "id": "GO:0050877"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 33, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 31
        }, 
        {
            "end_pos": 61, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 59
        }, 
        {
            "end_pos": 69, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 67
        }, 
        {
            "end_pos": 177, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 175
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:285242", 
            "id": "hsa:285242", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-112314", 
            "id": "R-HSA-112314", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
            "id": "ENSG00000186038", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24005", 
            "id": "24005", 
            "database": "HGNC"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EFMDVDK/", 
            "id": "EFMDVDK", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006029", 
            "id": "IPR006029", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006201", 
            "id": "IPR006201", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006202", 
            "id": "IPR006202", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018000", 
            "id": "IPR018000", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036719", 
            "id": "IPR036719", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036734", 
            "id": "IPR036734", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTR3E", 
            "id": "HTR3E", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/285242", 
            "id": "285242", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02931", 
            "id": "PF02931", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02932", 
            "id": "PF02932", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945", 
            "id": "PTHR18945", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5X5Y0", 
            "id": "PR_A5X5Y0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A5X5Y0", 
            "id": "NX_A5X5Y0", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A5X5Y0*", 
            "id": "A5X5Y0", 
            "database": "IntAct"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5X5Y0", 
                    "id": "A5X5Y0", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A5X5Y0", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 51438.0, 
        "chemical_mass": 51438.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186038", 
                    "id": "ENSG00000186038", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24005", 
            "name": "HTR3E", 
            "locus": {
                "end_pos": 184106995, 
                "start_pos": 184097064, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000186038", 
                        "id": "ENSG00000186038", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}