{ "uniprot_canonical_ac": "A4Q9F4-1", "sequence": { "length": 727, "sequence": "MRRSSPEKKPEAEWEADAAAAAAATAAATESLPAETEKQQGVDAGAAGDPERLELEEQPKDVGRIPTPTRRHAPEEGEARVVRRLPPALPLAQPRPAARALSQLVKARGRSRSRVYRRSAGSMRPVTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPCDIYWHGVSFRDSDILSGQVNKFPGMTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEYELSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIHFPDIYMDRKHRIPPVSDRMSSWKHKGSSLSIVRSQQMEKSFTSKEDLNCDPTGGDSEPNPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRNCKLSSSSLSMAAVDILYIDITRRWNSVTVDQRDSGMCLQAFVEAFFFLAQRKFKLQPLHEQVASLIDLCEYHLSVLDEKRLLCHRGRPLQRNPPQMNRPEHSATGSSAPRVIGASKLSQS" }, "uniprot_id": "TTL11_MOUSE", "enzyme_annotation": [ { "ec": "6.-.-.-", "activity": "" } ], "alternativenames": [ { "full": "Tubulin--tyrosine ligase-like protein 11", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Tubulin polyglutamylase TTLL11" }, "publication": [ { "title": "Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20530212", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4/publications", "id": "A4Q9F4", "database": "UniProtKB" } ], "authors": "Gerlich D.W., Janke C., Guizetti J., Aldrian-Herrada G., Gold N.D., Lacroix B., Rogowski K., van Dijk J.", "date": "2010", "pmid": "20530212" }, { "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4/publications", "id": "A4Q9F4", "database": "UniProtKB" } ], "authors": "Janke C., Lacroix B., Rogowski K., van Dijk J., Miro J., Edde B.", "date": "2007", "pmid": "17499049" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4#A4Q9F4-1", "isoform_ac": "A4Q9F4-1", "locus": { "end_pos": 35752236, "start_pos": 35979624, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028248", "id": "ENSMUST00000028248", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028248", "id": "ENSMUSP00000028248", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 727, "sequence": "MRRSSPEKKPEAEWEADAAAAAAATAAATESLPAETEKQQGVDAGAAGDPERLELEEQPKDVGRIPTPTRRHAPEEGEARVVRRLPPALPLAQPRPAARALSQLVKARGRSRSRVYRRSAGSMRPVTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPCDIYWHGVSFRDSDILSGQVNKFPGMTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEYELSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIHFPDIYMDRKHRIPPVSDRMSSWKHKGSSLSIVRSQQMEKSFTSKEDLNCDPTGGDSEPNPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRNCKLSSSSLSMAAVDILYIDITRRWNSVTVDQRDSGMCLQAFVEAFFFLAQRKFKLQPLHEQVASLIDLCEYHLSVLDEKRLLCHRGRPLQRNPPQMNRPEHSATGSSAPRVIGASKLSQS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F4#E0CY35-1", "isoform_ac": "E0CY35-1", "locus": { "end_pos": 35902648, "start_pos": 35940805, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000140201", "id": "ENSMUST00000140201", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124510", "id": "ENSMUSP00000124510", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 210, "sequence": "MTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTV" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F4#A4Q9F4-2", "isoform_ac": "A4Q9F4-2", "locus": { "end_pos": 35752236, "start_pos": 35979624, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112976", "id": "ENSMUST00000112976", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108600", "id": "ENSMUSP00000108600", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 694, "sequence": "MRRSSPEKKPEAEWEADAAAAAAATAAATESLPAETEKQQGVDAGAAGDPERLELEEQPKDVGRIPTPTRRHAPEEGEARVVRRLPPALPLAQPRPAARALSQLVKARGRSRSRVYRRSAGSMRPVTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPCDIYWHGVSFRDSDILSGQVNKFPGMTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEYELSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIQSQQMEKSFTSKEDLNCDPTGGDSEPNPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRNCKLSSSSLSMAAVDILYIDITRRWNSVTVDQRDSGMCLQAFVEAFFFLAQRKFKLQPLHEQVASLIDLCEYHLSVLDEKRLLCHRGRPLQRNPPQMNRPEHSATGSSAPRVIGASKLSQS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F4#E0CZ80-1", "isoform_ac": "E0CZ80-1", "locus": { "end_pos": 35903126, "start_pos": 35979624, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000161970", "id": "ENSMUST00000161970", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000125627", "id": "ENSMUSP00000125627", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 190, "sequence": "MRRSSPEKKPEAEWEADAAAAAAATAAATESLPAETEKQQGVDAGAAGDPERLELEEQPKDVGRIPTPTRRHAPEEGEARVVRRLPPALPLAQPRPAARALSQLVKARGRSRSRVYRRSAGSMRPVTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPCDIYWHGVSFRDSDILSGQVNKFPGPNGERR" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F4#A4Q9F4-3", "isoform_ac": "A4Q9F4-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 622, "sequence": "MRRSSPEKKPEAEWEADAAAAAAATAAATESLPAETEKQQGVDAGAAGDPERLELEEQPKDVGRIPTPTRRHAPEEGEARVVRRLPPALPLAQPRPAARALSQLVKARGRSRSRVYRRSAGSMRPVTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPCDIYWHGVSFRDSDILSGQVNKFPGMTEMVRKVTLSRALRIMQNLFPEEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEYELSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIQSQQMEKSFTSKEDLNCDPTGGDSEPNPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRNCKLSSSSLSMAAVDILYIDITRRWNSVTVDQRDSGMCLQAFVEAFFFLAQRKFKLQPLHEQVASLIDLCEYHLSVLDEKRLLCHRGRPLQRNPPQMNRPEHSATGSSAPRVIGASKLSQS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F4#F7BQM5-1", "isoform_ac": "F7BQM5-1", "locus": { "end_pos": 35752234, "start_pos": 35940806, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000160906", "id": "ENSMUST00000160906", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000125511", "id": "ENSMUSP00000125511", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 511, "sequence": "XMTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEYELSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIQSQQMEKSFTSKEDLNCDPTGGDSEPNPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRNCKLSSSSLSMAAVDILYIDITRRWNSVTVDQRDSGMCLQAFVEAFFFLAQRKFKLQPLHEQVASLIDLCEYHLSVLDEKRLLCHRGRPLQRNPPQMNRPEHSATGSSAPRVIGASKLSQS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F4#E0CXL9-1", "isoform_ac": "E0CXL9-1", "locus": { "end_pos": 35902666, "start_pos": 35940805, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000162172", "id": "ENSMUST00000162172", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000125199", "id": "ENSMUSP00000125199", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 204, "sequence": "MTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIIS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:74410", "resource": "KEGG Pathway", "id": "mmu:74410", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "resource": "Reactome", "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4#function", "annotation": "Polyglutamase which preferentially modifies alpha-tubulin (PubMed:17499049). Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Required for CCSAP localization to both spindle and cilia microtubules (PubMed:17499049). Generates long side-chains (PubMed:20530212).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4#function", "id": "A4Q9F4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8NHH1-1", "protein_name": "Tubulin polyglutamylase TTLL11", "sequence": { "length": 800, "sequence": "MAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAAVNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQVRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPGMTEMVRKITLSRAVRTMQNLFPEEYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRLAGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPTPKNLHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISVVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPILLEVNANPSMRIEHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMDPLKKKRENQSQQLEKPFAGKEDALDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPSPSAQPAGDNPPPRTSCANKLSHPRHTLS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/77534", "id": "77534", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084050.1", "ac": "NP_084050.1", "name": "tubulin polyglutamylase TTLL11", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "ligase activity", "id": "GO:0016874" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051013", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "microtubule severing", "id": "GO:0051013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F4", "id": "A4Q9F4", "database": "UniProtKB" } ], "name": "protein polyglutamylation", "id": "GO:0018095" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 343, "annotation": "n_glycosylation_sequon", "start_pos": 341 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:74410", "id": "mmu:74410", "database": "KEGG Pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "id": "R-MMU-8955332", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026885", "id": "ENSMUSG00000026885", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:1921660", "id": "1921660", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/CANKLSH/", "id": "CANKLSH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "id": "IPR013815", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "id": "IPR004344", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/74410", "id": "74410", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF03133", "id": "PF03133", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4Q9F4", "id": "PR_A4Q9F4", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A4Q9F4", "disease": [], "mass": { "monoisotopic_mass": 82361.0, "chemical_mass": 82361.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:1921660", "name": "Ttll11", "locus": { "end_pos": 35751241, "start_pos": 35979913, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026885", "id": "ENSMUSG00000026885", "database": "Ensembl Gene" } ] } } ] }