{ "uniprot_canonical_ac": "A4GTP4-1", "sequence": { "length": 427, "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAVAMAPATVHSGPGDNATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPPLHPRPASVLPNTTPAGVPAPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLNPGFGRPQPPEVKVEGPKEELEVTEVGGFSPEAVKAEQEVSPSEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAQGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP" }, "uniprot_id": "ELK1_RAT", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "ETS domain-containing protein Elk-1" }, "publication": [ { "title": "JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses neuronal differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17156131", "journal": "J. Neurochem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4/publications", "id": "A4GTP4", "database": "UniProtKB" } ], "authors": "Kim E.J., Chung K.C., Park J.B., Seo S.R., Yang E.J.", "date": "2007", "pmid": "17156131" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4#A4GTP4-1", "isoform_ac": "A4GTP4-1", "locus": { "end_pos": 1297144, "start_pos": 1303526, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000013522", "id": "ENSRNOT00000013522", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000013522", "id": "ENSRNOP00000013522", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 427, "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAVAMAPATVHSGPGDNATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPPLHPRPASVLPNTTPAGVPAPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLNPGFGRPQPPEVKVEGPKEELEVTEVGGFSPEAVKAEQEVSPSEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAQGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:314436", "resource": "KEGG Pathway", "id": "rno:314436", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4#function", "annotation": "Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131). Induces target gene transcription upon JNK-signaling pathway stimulation (PubMed:17156131).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4#function", "id": "A4GTP4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P19419-1", "protein_name": "ETS domain-containing protein Elk-1", "sequence": { "length": 428, "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A4GTP4/", "id": "A4GTP4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/3832", "id": "3832", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "P41969-1", "protein_name": "ETS domain-containing protein Elk-1", "sequence": { "length": 429, "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAIAMAPATVHAGPGDTATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPQPPIPPRPASVLPNTTPAGVPAPASGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLDPSFGHPQPPEVKVEGPKEELEAARAGGFSSEAVKAEPEVSASEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A4GTP4/", "id": "A4GTP4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/3832", "id": "3832", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "double-stranded DNA binding", "id": "GO:0003690" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001085", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription factor binding", "id": "GO:0001085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "axon terminus", "id": "GO:0043679" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071394", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "cellular response to testosterone stimulus", "id": "GO:0071394" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901216", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "positive regulation of neuron death", "id": "GO:1901216" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009416", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "response to light stimulus", "id": "GO:0009416" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071774", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "response to fibroblast growth factor", "id": "GO:0071774" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071480", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "cellular response to gamma radiation", "id": "GO:0071480" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GTP4", "id": "A4GTP4", "database": "UniProtKB" } ], "name": "cellular response to lipid", "id": "GO:0071396" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 53, "annotation": "n_glycosylation_sequon", "start_pos": 51 }, { "end_pos": 127, "annotation": "n_glycosylation_sequon", "start_pos": 125 }, { "end_pos": 184, "annotation": "n_glycosylation_sequon", "start_pos": 182 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:314436", "id": "rno:314436", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010171", "id": "ENSRNOG00000010171", "database": "Bgee" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1598663", "id": "1598663", "database": "RGD" }, { "url": "https://omabrowser.org/oma/group/NTAQVCG/", "id": "NTAQVCG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "id": "IPR036388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "id": "IPR000418", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/314436", "id": "314436", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00178", "id": "PF00178", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4GTP4", "id": "PR_A4GTP4", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A4GTP4", "disease": [], "mass": { "monoisotopic_mass": 45272.0, "chemical_mass": 45272.0 }, "expression_tissue": [], "gene": [ { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1598663", "name": "Elk1", "locus": { "end_pos": 1304822, "start_pos": 1297099, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000010171", "id": "ENSRNOG00000010171", "database": "Ensembl Gene" } ] } } ] }