{
    "uniprot_canonical_ac": "A3QPB9-1", 
    "sequence": {
        "length": 146, 
        "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS"
    }, 
    "uniprot_id": "IL21_RAT", 
    "enzyme_annotation": [], 
    "alternativenames": [], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                    "id": "A3QPB9", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Interleukin-21", 
        "short": "IL-21"
    }, 
    "publication": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3QPB9#ptm_processing", 
                    "id": "A3QPB9-1", 
                    "database": "UniProtKB"
                }
            ], 
            "relation": "attached", 
            "position": 85, 
            "glytoucan_ac": "GlcNAc...", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A3QPB9#A3QPB9-1", 
            "isoform_ac": "A3QPB9-1", 
            "locus": {
                "end_pos": 123965024, 
                "start_pos": 123972356, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000023348", 
                        "id": "ENSRNOT00000023348", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000023348", 
                        "id": "ENSRNOP00000023348", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 146, 
                "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:365769", 
            "resource": "KEGG Pathway", 
            "id": "rno:365769", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020958", 
            "resource": "Reactome", 
            "id": "R-RNO-9020958", 
            "name": "Interleukin-21 signaling"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A3QPB9#function", 
            "annotation": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3QPB9#function", 
                    "id": "A3QPB9", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9ES17-1", 
            "protein_name": "Interleukin-21", 
            "sequence": {
                "length": 146, 
                "sequence": "MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/11032", 
                    "id": "11032", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A3QPB9/", 
                    "id": "A3QPB9", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9HBE4-1", 
            "protein_name": "Interleukin-21", 
            "sequence": {
                "length": 162, 
                "sequence": "MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/11032", 
                    "id": "11032", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", 
        "ac": "NP_001102413.1", 
        "name": "interleukin-21 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytokine activity", 
                        "id": "GO:0005125"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "interleukin-2 receptor binding", 
                        "id": "GO:0005134"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032740", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interleukin-17 production", 
                        "id": "GO:0032740"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immune response", 
                        "id": "GO:0006955"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030890", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of B cell proliferation", 
                        "id": "GO:0030890"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042102", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of T cell proliferation", 
                        "id": "GO:0042102"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048469", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell maturation", 
                        "id": "GO:0048469"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of natural killer cell mediated cytotoxicity", 
                        "id": "GO:0045954"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042531", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of tyrosine phosphorylation of STAT protein", 
                        "id": "GO:0042531"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007260", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QPB9", 
                                "id": "A3QPB9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tyrosine phosphorylation of STAT protein", 
                        "id": "GO:0007260"
                    }
                ], 
                "total": 8, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 87, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 85
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:365769", 
            "id": "rno:365769", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020958", 
            "id": "R-RNO-9020958", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017376", 
            "id": "ENSRNOG00000017376", 
            "database": "Bgee"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307384", 
            "id": "1307384", 
            "database": "RGD"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/ERSAFSC/", 
            "id": "ERSAFSC", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003443", 
            "id": "IPR003443", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", 
            "id": "IPR009079", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038327", 
            "id": "IPR038327", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/365769", 
            "id": "365769", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02372", 
            "id": "PF02372", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14356", 
            "id": "PTHR14356", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A3QPB9", 
            "id": "PR_A3QPB9", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A3QPB9", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 17065.0, 
        "chemical_mass": 17065.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307384", 
            "name": "Il21", 
            "locus": {
                "end_pos": 123965021, 
                "start_pos": 123972356, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000017376", 
                        "id": "ENSRNOG00000017376", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}