{ "uniprot_canonical_ac": "A2VD12-1", "sequence": { "length": 722, "sequence": "MASCPDSDNSWVLAGSETLPVETLGPESRVDPESEEAPQALQDSSKADGKESAGTLNGEEMLFQTESSQGEGAALPEESEAKGALGGDDGHGTKRPGDTAVQEDLQETPMVTSLGPDTQDLERNIHPQNLPSSPRAVWKEHGCSSSDDDTDVDVEGLRRRRGREPSPPQPTAAVDGEDQAKGEGIGELGISLNMCFLGALVLLGLGILLFSGALLEPETEPVEEAELQVFPETELVQTVGNRQDEVEQLQASVPPDSVPSLQSMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGSPQGGKATTEQGHKGQEPDTSLLEQHKQLEAEAKALRQELQKQWQLLGSVHRNLQRGLQDAGQGAPAHAGLAELGHMLAQTLQGLESQGINTGRSSNDSEAWHQKKPRFQHPREWSGREKWRGGQRDQKAEHWKLKKEESGQDRKKSWRDEGREFTGHWKENRPRAEESGSRKDSKRQDPKVHPRKSGNSHSGERQKHSWGKDNSPDSVSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLARLPWAGQLTKELPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFIFSHFFGDKALKRRSKKKEKQPWNHRAVGPREEHSRHPHHYHQG" }, "uniprot_id": "PBIP1_RAT", "enzyme_annotation": [], "alternativenames": [ { "full": "Hematopoietic PBX-interacting protein", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Pre-B-cell leukemia transcription factor-interacting protein 1" }, "publication": [ { "title": "Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "journal": "Journal of proteome research", "evidence": [ { "url": "http://www.unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" } ], "authors": "Parker BL, Thaysen-Andersen M, Solis N, Scott NE, Larsen MR, Graham ME, Packer NH, Cordwell SJ", "date": "2013", "pmid": "24090084" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12/publications", "id": "A2VD12", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "id": "24090084", "database": "PubMed" } ], "relation": "attached", "position": 451, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "id": "24090084", "database": "PubMed" } ], "relation": "attached", "position": 451, "glytoucan_ac": "G09775CH", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "id": "24090084", "database": "PubMed" } ], "relation": "attached", "position": 451, "glytoucan_ac": "G37135JQ", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2VD12#A2VD12-1", "isoform_ac": "A2VD12-1", "locus": { "end_pos": 188766570, "start_pos": 188775664, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000028057", "id": "ENSRNOT00000028057", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000028058", "id": "ENSRNOP00000028058", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 722, "sequence": "MASCPDSDNSWVLAGSETLPVETLGPESRVDPESEEAPQALQDSSKADGKESAGTLNGEEMLFQTESSQGEGAALPEESEAKGALGGDDGHGTKRPGDTAVQEDLQETPMVTSLGPDTQDLERNIHPQNLPSSPRAVWKEHGCSSSDDDTDVDVEGLRRRRGREPSPPQPTAAVDGEDQAKGEGIGELGISLNMCFLGALVLLGLGILLFSGALLEPETEPVEEAELQVFPETELVQTVGNRQDEVEQLQASVPPDSVPSLQSMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGSPQGGKATTEQGHKGQEPDTSLLEQHKQLEAEAKALRQELQKQWQLLGSVHRNLQRGLQDAGQGAPAHAGLAELGHMLAQTLQGLESQGINTGRSSNDSEAWHQKKPRFQHPREWSGREKWRGGQRDQKAEHWKLKKEESGQDRKKSWRDEGREFTGHWKENRPRAEESGSRKDSKRQDPKVHPRKSGNSHSGERQKHSWGKDNSPDSVSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLARLPWAGQLTKELPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFIFSHFFGDKALKRRSKKKEKQPWNHRAVGPREEHSRHPHHYHQG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:310644", "resource": "KEGG Pathway", "id": "rno:310644", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2VD12#function", "annotation": "Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12#function", "id": "A2VD12", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q96AQ6-1", "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "sequence": { "length": 731, "sequence": "MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10740", "id": "10740", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2VD12/", "id": "A2VD12", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q3TVI8-1", "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "sequence": { "length": 727, "sequence": "MASCPDSDNSWVLAGSENLPVETLGPEPRMDPESEGASQALRDSSKADGKELAGTLDGEEKLFQTESSQRETAVLTESAAKGTLGADGHGTEAPGDTVVQEDSQETPVATSLGPDTQDLESEIHPQNLPSSPRAVWKEHRCSSSDDDTDVDVEGLRRRRGREPSSSQPVVPVDVEDQAKGEGIGGELGISLNMCFLGALVLLGLGILLFSGTLLEPETGPMEEAELQVFPETGPETELVETLGNRQDEIEHLQASSVPPDSVPSLQSMGFLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGDPQDGKATKEQGHKGQEPDPSLLEQHKQLEAEAKALRQELQRQWQLLGSVHWDLQRGLRDAGRGAPAHPGLAELGHMLAQTLQDLENQGINTGRSPNDSEAWHQKKPHTQSPREWGGKEKWRGGQRDQKAEHWKPRKEESGQERQRSWRDEGREHTGRWREDRLRADESGSRKDSKRQDPKVHPRKDGNSHSVERQKHSWGKDNSPDALSSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLSRLPWAGQLTKQLPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFVFGHFFGDKALKKRSRKKEKHSWNPRVVGPREEHSRHPHHYHQG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10740", "id": "10740", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2VD12/", "id": "A2VD12", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001106", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "regulation of Rho guanyl-nucleotide exchange factor activity", "id": "GO:2001106" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 453, "annotation": "n_glycosylation_sequon", "start_pos": 451 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:310644", "id": "rno:310644", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020673", "id": "ENSRNOG00000020673", "database": "Bgee" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305180", "id": "1305180", "database": "RGD" }, { "url": "https://omabrowser.org/oma/group/LMQQPKG/", "id": "LMQQPKG", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033589", "id": "IPR033589", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/310644", "id": "310644", "database": "GeneID" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28638:SF1", "id": "PTHR28638:SF1", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2VD12", "id": "PR_A2VD12", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A2VD12", "disease": [], "mass": { "monoisotopic_mass": 80276.0, "chemical_mass": 80276.0 }, "expression_tissue": [], "gene": [ { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305180", "name": "Pbxip1", "locus": { "end_pos": 188776439, "start_pos": 188766535, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020673", "id": "ENSRNOG00000020673", "database": "Ensembl Gene" } ] } } ] }