{
    "uniprot_canonical_ac": "A2RTX5-1", 
    "sequence": {
        "length": 802, 
        "sequence": "MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQAEGPCLTREVAQLRAENCDLRHRLCSLRLCLAEERSRQATLESAELEAAQEAGAQPPPSQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLAIYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKKIRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRKTRTLNAEEAF"
    }, 
    "uniprot_id": "SYTC2_HUMAN", 
    "enzyme_annotation": [
        {
            "ec": "6.1.1.3", 
            "activity": "ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)."
        }, 
        {
            "ec": "6.1.1.3", 
            "activity": ""
        }
    ], 
    "alternativenames": [
        {
            "full": "Threonyl-tRNA synthetase", 
            "short": "ThrRS"
        }, 
        {
            "full": "Threonyl-tRNA synthetase-like protein 2", 
            "short": ""
        }
    ], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Threonine--tRNA ligase 2, cytoplasmic"
    }, 
    "publication": [
        {
            "title": "Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24312579", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689547.2", 
                    "id": "NP_689547.2", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A2RTX5/publications", 
                    "id": "A2RTX5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kim K, Park SJ, Na S, Kim JS, Choi H, Kim YK, Paek E, Lee C", 
            "date": "2013", 
            "pmid": "24312579"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 562, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0152", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", 
            "sequence_org": "L", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "S", 
            "subjects_tested": "66", 
            "end_pos": 562, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 433, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0152", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/66 (0.0152)", 
            "sequence_org": "N", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "S", 
            "subjects_tested": "66", 
            "end_pos": 433, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 96, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0106", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "G", 
            "subjects_tested": "94", 
            "end_pos": 96, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 96, 
            "subjects_positive": "4", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0157", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 4/254 (0.0157)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "G", 
            "subjects_tested": "254", 
            "end_pos": 96, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 83, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "S", 
            "subjects_tested": "50", 
            "end_pos": 83, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 72, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "W", 
            "subjects_tested": "50", 
            "end_pos": 72, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 62, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "C", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "F", 
            "subjects_tested": "50", 
            "end_pos": 62, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 56, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "Q", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "50", 
            "end_pos": 56, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 53, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0263", 
            "annotation": "Somatic mutation in Lung cancer (DOID:1324) with frequency of 1/38 (0.0263)", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "38", 
            "end_pos": 53, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 39, 
            "subjects_positive": "5", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0197", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 5/254 (0.0197)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "S", 
            "subjects_tested": "254", 
            "end_pos": 39, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 35, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "K", 
            "subjects_tested": "50", 
            "end_pos": 35, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 18, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "Q", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "50", 
            "end_pos": 18, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 4, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "K", 
            "subjects_tested": "50", 
            "end_pos": 4, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RTX5#A2RTX5-2", 
            "isoform_ac": "A2RTX5-2", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "length": 707, 
                "sequence": "MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQAEGPCLTREVAQLRAENCDLRHRLCSLRLCLAEERSRQATLESAELEAAQEAGAQPPPSQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLAIYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKKIRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRKTRTLNAEEAF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RTX5#H0YKB9-1", 
            "isoform_ac": "H0YKB9-1", 
            "locus": {
                "end_pos": 101699418, 
                "start_pos": 101708828, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000558533", 
                        "id": "ENST00000558533", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000452740", 
                        "id": "ENSP00000452740", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 148, 
                "sequence": "EVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIRMQDRCG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RTX5#A2RTX5-1", 
            "isoform_ac": "A2RTX5-1", 
            "locus": {
                "end_pos": 101654585, 
                "start_pos": 101724387, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000335968", 
                        "id": "ENST00000335968", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000338093", 
                        "id": "ENSP00000338093", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 802, 
                "sequence": "MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQAEGPCLTREVAQLRAENCDLRHRLCSLRLCLAEERSRQATLESAELEAAQEAGAQPPPSQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLAIYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKKIRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRKTRTLNAEEAF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RTX5#B7ZLP8-1", 
            "isoform_ac": "B7ZLP8-1", 
            "locus": {
                "end_pos": 101655983, 
                "start_pos": 101724387, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000539112", 
                        "id": "ENST00000539112", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000439899", 
                        "id": "ENSP00000439899", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 766, 
                "sequence": "MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQAEGPCLTREVAQLRAENCDLRHRLCSLRLCLAEERSRQATLESAELEAAQEAGAQPPPSQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLAIYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKKIRNAQLAQYNFILDRFLPSVWQEAWL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:123283", 
            "resource": "KEGG Pathway", 
            "id": "hsa:123283", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RTX5#function", 
            "annotation": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RTX5#function", 
                    "id": "A2RTX5", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689547.2", 
            "annotation": "TARSL2 is potentially a new component of aminoacyl-tRNA synthetase core-complex Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689547.2", 
                    "id": "NP_689547.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q5XI17-1", 
            "protein_name": "", 
            "sequence": {
                "length": 553, 
                "sequence": "MAAQALAAQAVASRLQRQEEDIRWLCAEVQRLRDEQLRGPERGQAEGPRLTREVAQLQAENRDLHQRLCDLRLRLAEQGGPGARRAAAHEPPTQNQEKDTKRKRLKDSEPNREVKQPNFIKERLQLFETLKTDHQLLPATQEKKNTNNVISVRVAGGKTVQGEEWKTTPYQVAAGISKELAENTVIAKVNGVLWDLDRPLEGDSTVELLMFDNEEAQAVYWHSSAHVLGEAMELYYGGHLCYGPPIENGFYYDMFIGDRVVSSTELSALENICKTIIKEKQPFERLEVSKDSLLEMFKYNKFKCRILKEKVDTPTTTVYRCGPLIDLCKGPHVRHTGKIKAIKIFKNSSTYWEGNPEMETLQRVYGISFPDSKMMRDWEKFQEEARSRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLMDFIREEYHKRNFTEVLSPNMYNSKLWETSGHWQHYSNNMFTFDIEKDTFALKPMNCPGHCLMFAHRPRSWREMPVRFADFGVLHRNELSGTLTGLTRVRRFQQDDAHIFCMVEQLKLPCRGDCQTLQTV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/65036", 
                    "id": "65036", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8BLY2-1", 
            "protein_name": "Threonine--tRNA ligase 2, cytoplasmic", 
            "sequence": {
                "length": 790, 
                "sequence": "MAAQALAAQAVASRLQRQEEDIRWLCAEVQRLRDEQLRGPERGQAEGPRLTREVAQLQAENRDLHQRLCGLRLRLAEQRRTEAGRAAAHEPPTQNQEKDTKKKRLKQSEPGREVKQPNFIKERLQLFETLKTDHQLLPATQEKKNTNNVISVRVAGGKTVQGERWKTTPYQVAAGISKELAEHTVIAKVNGVLWDLDRPLEGDSTVELLMFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRVVSSTELSALENICKTIIKEKQPFERLEVSKDTLLEMFKYNKFKCRILKEKVDTPTTTVYRCGPLIDLCKGPHVRHTGKIKAIKIFKNSSTYWEGNPEMETLQRIYGISFPDSKMMKDWEKFQEEAKSRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNALMDFIREEYHKRNFTEVLSPNMYNSKLWETSGHWQHYSNNMFTFDVEKDTFALKPMNCPGHCLMFAHRPRSWREMPVRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCMVEQIEEEIKGCLHFLQSVYSTFGFSFQLNLSTRPEHFLGEIEIWDEAERQLQNSLVEFGKPWKINPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKNRPVIIHRAILGSVERMIAILSENYGGKWPLWLSPRQVMVIPVGPACENYALQVSKECFEEGFMADVDLDDSCTLNKKIRNAQLAQYNFILVVGEKEKINNAVNVRTRDNKIHGEISIASVIEKLKNLKKSRTLNAEEDF"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RTX5/", 
                    "id": "A2RTX5", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/65036", 
                    "id": "65036", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689547.2", 
        "ac": "NP_689547.2", 
        "name": "threonine--tRNA ligase 2, cytoplasmic", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RTX5", 
                                "id": "A2RTX5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RTX5", 
                                "id": "A2RTX5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "threonine-tRNA ligase activity", 
                        "id": "GO:0004829"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RTX5", 
                                "id": "A2RTX5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RTX5", 
                                "id": "A2RTX5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006435", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RTX5", 
                                "id": "A2RTX5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "threonyl-tRNA aminoacylation", 
                        "id": "GO:0006435"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 361, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 359
        }, 
        {
            "end_pos": 578, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 576
        }, 
        {
            "end_pos": 653, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 651
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:123283", 
            "id": "hsa:123283", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185418", 
            "id": "ENSG00000185418", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24728", 
            "id": "24728", 
            "database": "HGNC"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DAHIFML/", 
            "id": "DAHIFML", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00771", 
            "id": "cd00771", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004095", 
            "id": "IPR004095", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012676", 
            "id": "IPR012676", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012675", 
            "id": "IPR012675", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012947", 
            "id": "IPR012947", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018163", 
            "id": "IPR018163", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004154", 
            "id": "IPR004154", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033728", 
            "id": "IPR033728", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036621", 
            "id": "IPR036621", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002314", 
            "id": "IPR002314", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006195", 
            "id": "IPR006195", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002320", 
            "id": "IPR002320", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TARSL2", 
            "id": "TARSL2", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/123283", 
            "id": "123283", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02824", 
            "id": "PF02824", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07973", 
            "id": "PF07973", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03129", 
            "id": "PF03129", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00587", 
            "id": "PF00587", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11451", 
            "id": "PTHR11451", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RTX5", 
            "id": "PR_A2RTX5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A2RTX5", 
            "id": "NX_A2RTX5", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RTX5*", 
            "id": "A2RTX5", 
            "database": "IntAct"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
        }, 
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            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RTX5", 
                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
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                "url": "http://disease-ontology.org/term/DOID:3907", 
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                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
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                    "id": "A2RTX5", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A2RTX5", 
    "disease": [], 
    "mass": {
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        "chemical_mass": 92646.0
    }, 
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        {
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                "uberon": "0000473", 
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        }, 
        {
            "tissue": {
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                "name": "Adrenal gland"
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        {
            "tissue": {
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        }, 
        {
            "tissue": {
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        {
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            ]
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            ]
        }
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                ]
            }
        }
    ]
}