{ "uniprot_canonical_ac": "A2RRU4-1", "sequence": { "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "uniprot_id": "SCAP_RAT", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Sterol regulatory element-binding protein cleavage-activating protein", "short": "SREBP cleavage-activating protein" }, "publication": [], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing", "id": "A2RRU4-1", "database": "UniProtKB" } ], "relation": "attached", "position": 263, "glytoucan_ac": "GlcNAc...", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing", "id": "A2RRU4-1", "database": "UniProtKB" } ], "relation": "attached", "position": 590, "glytoucan_ac": "GlcNAc...", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing", "id": "A2RRU4-1", "database": "UniProtKB" } ], "relation": "attached", "position": 641, "glytoucan_ac": "GlcNAc...", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#A2RRU4-1", "isoform_ac": "A2RRU4-1", "locus": { "end_pos": 118596844, "start_pos": 118628485, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090238", "id": "ENSRNOT00000090238", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072003", "id": "ENSRNOP00000072003", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:301024", "resource": "KEGG Pathway", "id": "rno:301024", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "resource": "Reactome", "id": "R-RNO-1655829", "name": "Regulation of cholesterol biosynthesis by SREBP (SREBF)" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#function", "annotation": "Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#function", "id": "A2RRU4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q12770-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "sequence": { "length": 1279, "sequence": "MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPERGGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLRLNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGIVLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDGGKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8160", "id": "8160", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6GQT6-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "sequence": { "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQQAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAGPAEGVHDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRSAWAPQEPLPAGLWESGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFETQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRVGCGRSRDSGYDFSRLVQRVYQEEGLAAMRMPALRPPSPGPPLPQASQEEGTAPEKGSPPLAWTPSTAGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSSVYSSSNTVTCHRTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLDDSCCLFTLKGHSGAITAVYIDQTMVLASGGQDGAICLWDVLTGSRVSQTFAHRGDVTSLTCTASCVISSGLDDFISIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8160", "id": "8160", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "protein-containing complex binding", "id": "GO:0044877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032934", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "sterol binding", "id": "GO:0032934" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012507", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "ER to Golgi transport vesicle membrane", "id": "GO:0012507" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "immune response", "id": "GO:0006955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "cholesterol metabolic process", "id": "GO:0008203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044255", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "cellular lipid metabolic process", "id": "GO:0044255" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "response to hypoxia", "id": "GO:0001666" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042304", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of fatty acid biosynthetic process", "id": "GO:0042304" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045540", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of cholesterol biosynthetic process", "id": "GO:0045540" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007568", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "aging", "id": "GO:0007568" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "response to insulin", "id": "GO:0032868" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032933", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "SREBP signaling pathway", "id": "GO:0032933" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 }, { "end_pos": 592, "annotation": "n_glycosylation_sequon", "start_pos": 590 }, { "end_pos": 643, "annotation": "n_glycosylation_sequon", "start_pos": 641 }, { "end_pos": 881, "annotation": "n_glycosylation_sequon", "start_pos": 879 }, { "end_pos": 1025, "annotation": "n_glycosylation_sequon", "start_pos": 1023 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:301024", "id": "rno:301024", "database": "KEGG Pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "id": "R-RNO-1655829", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020853", "id": "ENSRNOG00000020853", "database": "Bgee" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309378", "id": "1309378", "database": "RGD" }, { "url": "https://omabrowser.org/oma/group/PIVADKC/", "id": "PIVADKC", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", "id": "IPR000731", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030225", "id": "IPR030225", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/301024", "id": "301024", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12349", "id": "PF12349", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46378", "id": "PTHR46378", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RRU4", "id": "PR_A2RRU4", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A2RRU4", "disease": [], "mass": { "monoisotopic_mass": 139499.0, "chemical_mass": 139499.0 }, "expression_tissue": [], "gene": [ { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309378", "name": "Scap", "locus": { "end_pos": 118628651, "start_pos": 118570503, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020853", "id": "ENSRNOG00000020853", "database": "Ensembl Gene" } ] } } ] }