{
    "uniprot_canonical_ac": "A2RRD8-1", 
    "sequence": {
        "length": 509, 
        "sequence": "MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMNTLSSTGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQEDETNDHEAPMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGEKPYKCEECEKVFSCKSHLEIHRIIHTGEKPYKCKVCDKAFKHDSHLAKHTRIHRGDKHYTCNECGKVFDQKATLACHHRSHTGEKPYKCNECGKTFSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGEKPYRCEECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRSDSRLAEHQRVHTGERPYTCNECGKVFSTKAYLACHQKLHTGEKLYECEECDKVYIRKSHLERHRRIHTGEKPHKCGDCGKAFNSPSHLIRHQRIHTGQKSYKCHQCGKVFSLRSLLAEHQKIPFGDNCFKCNEYSKPSSIN"
    }, 
    "uniprot_id": "ZN320_HUMAN", 
    "enzyme_annotation": [], 
    "alternativenames": [], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Zinc finger protein 320"
    }, 
    "publication": [
        {
            "title": "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11536051", 
            "journal": "Oncogene", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRD8/publications", 
                    "id": "A2RRD8", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Malaj E., Pan H., Cowell J.K., Roe B., Chernova O.B., Crooks C., Hunyadi A.", 
            "date": "2001", 
            "pmid": "11536051"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 473, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0108", 
            "annotation": "Somatic mutation in Ovarian cancer (DOID:2394) with frequency of 1/93 (0.0108)", 
            "sequence_org": "Q", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "K", 
            "subjects_tested": "93", 
            "end_pos": 473, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 449, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0227", 
            "annotation": "Somatic mutation in Head and neck cancer (DOID:11934) with frequency of 1/44 (0.0227)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "11934", 
                "url": "http://disease-ontology.org/term/DOID:11934", 
                "icd10": "", 
                "name": "Head and neck cancer"
            }, 
            "sequence_mut": "T", 
            "subjects_tested": "44", 
            "end_pos": 449, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 186, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0106", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", 
            "sequence_org": "E", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "D", 
            "subjects_tested": "94", 
            "end_pos": 186, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 138, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0108", 
            "annotation": "Somatic mutation in Ovarian cancer (DOID:2394) with frequency of 1/93 (0.0108)", 
            "sequence_org": "G", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "S", 
            "subjects_tested": "93", 
            "end_pos": 138, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 17, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0106", 
            "annotation": "Somatic mutation in Colorectal cancer (DOID:9256) with frequency of 1/94 (0.0106)", 
            "sequence_org": "F", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "94", 
            "end_pos": 17, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#A2RRD8-1", 
            "isoform_ac": "A2RRD8-1", 
            "locus": {
                "end_pos": 52880599, 
                "start_pos": 52890255, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000595635", 
                        "id": "ENST00000595635", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000473091", 
                        "id": "ENSP00000473091", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 509, 
                "sequence": "MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMNTLSSTGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQEDETNDHEAPMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGEKPYKCEECEKVFSCKSHLEIHRIIHTGEKPYKCKVCDKAFKHDSHLAKHTRIHRGDKHYTCNECGKVFDQKATLACHHRSHTGEKPYKCNECGKTFSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGEKPYRCEECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRSDSRLAEHQRVHTGERPYTCNECGKVFSTKAYLACHQKLHTGEKLYECEECDKVYIRKSHLERHRRIHTGEKPHKCGDCGKAFNSPSHLIRHQRIHTGQKSYKCHQCGKVFSLRSLLAEHQKIPFGDNCFKCNEYSKPSSIN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#M0R1K6-1", 
            "isoform_ac": "M0R1K6-1", 
            "locus": {
                "end_pos": 52881955, 
                "start_pos": 52890255, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000597265", 
                        "id": "ENST00000597265", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000471938", 
                        "id": "ENSP00000471938", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 57, 
                "sequence": "MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMNT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#M0QZA2-1", 
            "isoform_ac": "M0QZA2-1", 
            "locus": {
                "end_pos": 52881868, 
                "start_pos": 52890255, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000594741", 
                        "id": "ENST00000594741", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000470403", 
                        "id": "ENSP00000470403", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 86, 
                "sequence": "MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMNTLSSTGQGNTEVIHTGTLQRQASYHIGAFC"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#M0R0Z8-1", 
            "isoform_ac": "M0R0Z8-1", 
            "locus": {
                "end_pos": 52888194, 
                "start_pos": 52890255, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000597111", 
                        "id": "ENST00000597111", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000471548", 
                        "id": "ENSP00000471548", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 25, 
                "sequence": "MALSQGLLTFRDVAIEFSQEEWKCL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#M0R2L4-1", 
            "isoform_ac": "M0R2L4-1", 
            "locus": {
                "end_pos": 52881757, 
                "start_pos": 52890255, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000593618", 
                        "id": "ENST00000593618", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000472651", 
                        "id": "ENSP00000472651", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 123, 
                "sequence": "MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMNTLSSTGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQEDETNDHEAPMTEIKKLTSST"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#M0QX96-1", 
            "isoform_ac": "M0QX96-1", 
            "locus": {
                "end_pos": 52881619, 
                "start_pos": 52890255, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000597091", 
                        "id": "ENST00000597091", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000468995", 
                        "id": "ENSP00000468995", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 155, 
                "sequence": "MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQEDETNDHEAPMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGEKPYKCEECEKV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:162967", 
            "resource": "KEGG Pathway", 
            "id": "hsa:162967", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", 
            "resource": "Reactome", 
            "id": "R-HSA-212436", 
            "name": "Generic Transcription Pathway"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RRD8#function", 
            "annotation": "May be involved in transcriptional regulation.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRD8#function", 
                    "id": "A2RRD8", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRD8", 
                                "id": "A2RRD8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA binding", 
                        "id": "GO:0003677"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRD8", 
                                "id": "A2RRD8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRD8", 
                                "id": "A2RRD8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRD8", 
                                "id": "A2RRD8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription, DNA-templated", 
                        "id": "GO:0006355"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:162967", 
            "id": "hsa:162967", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", 
            "id": "R-HSA-212436", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182986", 
            "id": "ENSG00000182986", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=13842", 
            "id": "13842", 
            "database": "HGNC"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/YHIGALC/", 
            "id": "YHIGALC", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", 
            "id": "cd07765", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", 
            "id": "IPR013087", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", 
            "id": "IPR036236", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", 
            "id": "IPR001909", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", 
            "id": "IPR036051", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZNF320", 
            "id": "ZNF320", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/162967", 
            "id": "162967", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01352", 
            "id": "PF01352", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00096", 
            "id": "PF00096", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RRD8", 
            "id": "PR_A2RRD8", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A2RRD8", 
            "id": "NX_A2RRD8", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RRD8*", 
            "id": "A2RRD8", 
            "database": "IntAct"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RRD8", 
                    "id": "A2RRD8", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A2RRD8", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 59326.0, 
        "chemical_mass": 59326.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182986", 
                    "id": "ENSG00000182986", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182986", 
                    "id": "ENSG00000182986", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182986", 
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    ]
}