{ "uniprot_canonical_ac": "A2CG63-1", "sequence": { "length": 1314, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" }, "uniprot_id": "ARI4B_MOUSE", "enzyme_annotation": [], "alternativenames": [ { "full": "Histone deacetylase complex subunit SAP180", "short": "" }, { "full": "180 kDa Sin3-associated polypeptide", "short": "Sin3-associated polypeptide p180" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "AT-rich interactive domain-containing protein 4B", "short": "ARID domain-containing protein 4B" }, "publication": [ { "title": "Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28207192", "journal": "Stem cells (Dayton, Ohio)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ], "authors": "Wu RC, Zeng Y, Chen YF, Lanz RB, Wu MY", "date": "2017", "pmid": "28207192" }, { "title": "Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26258622", "journal": "Molecular endocrinology (Baltimore, Md.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ], "authors": "Wu RC, Zeng Y, Pan IW, Wu MY", "date": "2015", "pmid": "26258622" }, { "title": "ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23487765", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2CG63/publications", "id": "A2CG63", "database": "UniProtKB" } ], "authors": "Wu RC, Jiang M, Beaudet AL, Wu MY", "date": "2013", "pmid": "23487765" }, { "title": "Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18728284", "journal": "Journal of the National Cancer Institute", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2CG63/publications", "id": "A2CG63", "database": "UniProtKB" } ], "authors": "Wu MY, Eldin KW, Beaudet AL", "date": "2008", "pmid": "18728284" }, { "title": "Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17043311", "journal": "Genes Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63/publications", "id": "A2CG63", "database": "UniProtKB" } ], "authors": "Beaudet A.L., Wu M.Y., Tsai T.F.", "date": "2006", "pmid": "17043311" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2CG63#A2CG63-1", "isoform_ac": "A2CG63-1", "locus": { "end_pos": 14064874, "start_pos": 14197730, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000110534", "id": "ENSMUST00000110534", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106163", "id": "ENSMUSP00000106163", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 1314, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#A0A1Y7VIX3-1", "isoform_ac": "A0A1Y7VIX3-1", "locus": { "end_pos": 14064874, "start_pos": 14143009, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000222928", "id": "ENSMUST00000222928", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152177", "id": "ENSMUSP00000152177", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 128, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETRGGVFLLIQ" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#A2CG63-2", "isoform_ac": "A2CG63-2", "locus": { "end_pos": 14064874, "start_pos": 14197730, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000039538", "id": "ENSMUST00000039538", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000043889", "id": "ENSMUSP00000043889", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 1227, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#A0A1Y7VKA9-1", "isoform_ac": "A0A1Y7VKA9-1", "locus": { "end_pos": 14191177, "start_pos": 14191961, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000151151", "id": "ENSMUST00000151151", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152798", "id": "ENSMUSP00000152798", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 31, "sequence": "XGVGSSSKKQKRSHKATVVNNKKKGKGSAPH" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#Z4YMH1-1", "isoform_ac": "Z4YMH1-1", "locus": { "end_pos": 14064874, "start_pos": 14169958, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000129488", "id": "ENSMUST00000129488", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118687", "id": "ENSMUSP00000118687", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 540, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEE" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#Z4YL44-1", "isoform_ac": "Z4YL44-1", "locus": { "end_pos": 14064874, "start_pos": 14164364, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000110533", "id": "ENSMUST00000110533", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106162", "id": "ENSMUSP00000106162", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 473, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLVTSYC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:94246", "resource": "KEGG Pathway", "id": "mmu:94246", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2CG63#function", "annotation": "Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63#function", "id": "A2CG63", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "These results identified ARID4B as a master regulator of a signaling network that governs the establishment of a niche during the critical gonocyte-to-spermatogonial stem cells (SSC) transition phase to control the fate of gonocytes and SSCs.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "The study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "ARID4A and ARID4B function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q4LE39-1", "protein_name": "AT-rich interactive domain-containing protein 4B", "sequence": { "length": 1312, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12847", "id": "12847", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "ac": "NP_919238.1", "name": "AT-rich interactive domain-containing protein 4B isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "spermatogenesis", "id": "GO:0007283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006349", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "regulation of gene expression by genetic imprinting", "id": "GO:0006349" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034773", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "histone H4-K20 trimethylation", "id": "GO:0034773" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036124", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "histone H3-K9 trimethylation", "id": "GO:0036124" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097368", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "establishment of Sertoli cell barrier", "id": "GO:0097368" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 296, "annotation": "n_glycosylation_sequon", "start_pos": 294 }, { "end_pos": 859, "annotation": "n_glycosylation_sequon", "start_pos": 857 }, { "end_pos": 862, "annotation": "n_glycosylation_sequon", "start_pos": 860 }, { 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