{ "uniprot_canonical_ac": "A2AWT3-1", "sequence": { "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" }, "uniprot_id": "AT7L3_MOUSE", "enzyme_annotation": [], "alternativenames": [ { "full": "SAGA-associated factor 11 homolog", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Ataxin-7-like protein 3" }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3#A2AWT3-1", "isoform_ac": "A2AWT3-1", "locus": { "end_pos": 102291658, "start_pos": 102294999, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107134", "id": "ENSMUST00000107134", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102752", "id": "ENSMUSP00000102752", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } }, { "url": "https://www.uniprot.org/uniprot/A2AWT3#F6RCN9-1", "isoform_ac": "F6RCN9-1", "locus": { "end_pos": 102291656, "start_pos": 102294163, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000141516", "id": "ENSMUST00000141516", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121917", "id": "ENSMUSP00000121917", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 258, "sequence": "XRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGFSVCTSASNTLPLLFSSSGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } }, { "url": "https://www.uniprot.org/uniprot/A2AWT3#A2AWT3-2", "isoform_ac": "A2AWT3-2", "locus": { "end_pos": 102291658, "start_pos": 102294999, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107132", "id": "ENSMUST00000107132", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102750", "id": "ENSMUSP00000102750", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 354, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } }, { "url": "https://www.uniprot.org/uniprot/A2AWT3#Z4YN62-1", "isoform_ac": "Z4YN62-1", "locus": { "end_pos": 102291658, "start_pos": 102294987, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000137387", "id": "ENSMUST00000137387", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122610", "id": "ENSMUSP00000122610", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 350, "sequence": "EMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:217218", "resource": "KEGG Pathway", "id": "mmu:217218", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3#function", "annotation": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3#function", "id": "A2AWT3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q14CW9-1", "protein_name": "Ataxin-7-like protein 3", "sequence": { "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/35401", "id": "35401", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4A5H7-1", "protein_name": "Ataxin-7-like protein 3", "sequence": { "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALLSRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPAPSIYEDIN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/35401", "id": "35401", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092307.1", "ac": "NP_001092307.1", "name": "ataxin-7-like protein 3 isoform b", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "transcription coactivator activity", "id": "GO:0003713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030374", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "nuclear receptor transcription coactivator activity", "id": "GO:0030374" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071819", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "DUBm complex", "id": "GO:0071819" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "SAGA complex", "id": "GO:0000124" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016578", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "histone deubiquitination", "id": "GO:0016578" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010390", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "histone monoubiquitination", "id": "GO:0010390" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 90, "annotation": "n_glycosylation_sequon", "start_pos": 88 }, { "end_pos": 113, "annotation": "n_glycosylation_sequon", "start_pos": 111 }, { "end_pos": 129, "annotation": "n_glycosylation_sequon", "start_pos": 127 }, { "end_pos": 189, "annotation": "n_glycosylation_sequon", "start_pos": 187 }, { "end_pos": 303, "annotation": "n_glycosylation_sequon", "start_pos": 301 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:217218", "id": "mmu:217218", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000059995", "id": "ENSMUSG00000059995", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:3036270", "id": "3036270", "database": "MGI" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013243", "id": "IPR013243", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013246", "id": "IPR013246", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/217218", "id": "217218", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF08313", "id": "PF08313", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08209", "id": "PF08209", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AWT3", "id": "PR_A2AWT3", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AWT3*", "id": "A2AWT3", "database": "IntAct" } ], "expression_disease": [], "uniprot_ac": "A2AWT3", "disease": [], "mass": { "monoisotopic_mass": 38594.0, "chemical_mass": 38594.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:3036270", "name": "Atxn7l3", "locus": { "end_pos": 102289300, "start_pos": 102296631, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000059995", "id": "ENSMUSG00000059995", "database": "Ensembl Gene" } ] } } ] }