{ "uniprot_canonical_ac": "A2AR95-1", "sequence": { "length": 345, "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPRDSVPSQGTEEV" }, "uniprot_id": "LRAD3_MOUSE", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Low-density lipoprotein receptor class A domain-containing protein 3" }, "publication": [ { "title": "LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21795536", "journal": "J. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95/publications", "id": "A2AR95", "database": "UniProtKB" } ], "authors": "Hyman B.T., Yepes M., Migliorini M., Mikhailenko I., Strickland D.K., Smith E., Ranganathan S., Battey F.D., Noyes N.C., Winkles J.A.", "date": "2011", "pmid": "21795536" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95#ptm_processing", "id": "A2AR95-1", "database": "UniProtKB" } ], "relation": "attached", "position": 24, "glytoucan_ac": "GlcNAc...", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AR95#A2AR95-1", "isoform_ac": "A2AR95-1", "locus": { "end_pos": 101952941, "start_pos": 102186325, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000058790", "id": "ENSMUST00000058790", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000054134", "id": "ENSMUSP00000054134", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 345, "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPRDSVPSQGTEEV" } }, { "url": "https://www.uniprot.org/uniprot/A2AR95#A2AR95-2", "isoform_ac": "A2AR95-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 331, "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASLPRSQQPPECGSQQPQPRAAWLSRGLC" } }, { "url": "https://www.uniprot.org/uniprot/A2AR95#A2AR95-3", "isoform_ac": "A2AR95-3", "locus": { "end_pos": 101952941, "start_pos": 102186325, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000111222", "id": "ENSMUST00000111222", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106853", "id": "ENSMUSP00000106853", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 313, "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPAKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPRDSVPSQGTEEV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241576", "resource": "KEGG Pathway", "id": "mmu:241576", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AR95#function", "annotation": "May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95#function", "id": "A2AR95", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LXB2-1", "protein_name": "", "sequence": { "length": 345, "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEGSSHSPEQPGPAESTSEPRDSVPSQGTEEV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18377", "id": "18377", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AR95/", "id": "A2AR95", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q86YD5-1", "protein_name": "Low-density lipoprotein receptor class A domain-containing protein 3", "sequence": { "length": 345, "sequence": "MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18377", "id": "18377", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AR95/", "id": "A2AR95", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849217.2", "ac": "NP_849217.2", "name": "low-density lipoprotein receptor class A domain-containing protein 3 isoform a precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "amyloid-beta binding", "id": "GO:0001540" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "receptor-mediated endocytosis", "id": "GO:0006898" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070613", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95", "database": "UniProtKB" } ], "name": "regulation of protein processing", "id": "GO:0070613" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 26, "annotation": "n_glycosylation_sequon", "start_pos": 24 }, { "end_pos": 107, "annotation": "n_glycosylation_sequon", "start_pos": 105 }, { "end_pos": 232, "annotation": "n_glycosylation_sequon", "start_pos": 230 }, { "end_pos": 251, "annotation": "n_glycosylation_sequon", "start_pos": 249 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241576", "id": "mmu:241576", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048058", "id": "ENSMUSG00000048058", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:2138856", "id": "2138856", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/PYCSESE/", "id": "PYCSESE", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "id": "cd00112", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "id": "IPR002172", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "id": "IPR023415", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "id": "IPR036055", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/241576", "id": "241576", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00057", "id": "PF00057", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AR95", "id": "PR_A2AR95", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A2AR95", "disease": [], "mass": { "monoisotopic_mass": 37467.0, "chemical_mass": 37467.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:2138856", "name": "Ldlrad3", "locus": { "end_pos": 101950203, "start_pos": 102186385, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000048058", "id": "ENSMUSG00000048058", "database": "Ensembl Gene" } ] } } ] }