{ "uniprot_canonical_ac": "A2AD83-1", "sequence": { "length": 703, "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASESMLDSRRRNSAVEVTFAAELEHSKPEAEATSLHPSQSSSSFTFIYADPVFNTDPEPIEFFEERSPLSSFQTTSKFADSHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLIMAEENMRPDSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFACTFAEQEFPTVLIDQSSAERYVASESSDSESEIIKPDYYFLYGKGTKSPRARIRLSSGSLQLEEEDETISFATPGAEDRTLLKPCNYFLA" }, "uniprot_id": "FRMD7_MOUSE", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "FERM domain-containing protein 7" }, "publication": [ { "title": "The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19892780", "journal": "Hum. Mol. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83/publications", "id": "A2AD83", "database": "UniProtKB" } ], "authors": "Crosier M., Lindsay S., Salomoni P., Bartesaghi S., Betts-Henderson J., Chen H.L., Gottlob I., Nicotera P.", "date": "2010", "pmid": "19892780" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AD83#A2AD83-1", "isoform_ac": "A2AD83-1", "locus": { "end_pos": 50895183, "start_pos": 50942710, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000060650", "id": "ENSMUST00000060650", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000057103", "id": "ENSMUSP00000057103", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 703, "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASESMLDSRRRNSAVEVTFAAELEHSKPEAEATSLHPSQSSSSFTFIYADPVFNTDPEPIEFFEERSPLSSFQTTSKFADSHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLIMAEENMRPDSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFACTFAEQEFPTVLIDQSSAERYVASESSDSESEIIKPDYYFLYGKGTKSPRARIRLSSGSLQLEEEDETISFATPGAEDRTLLKPCNYFLA" } }, { "url": "https://www.uniprot.org/uniprot/A2AD83#E9PXK8-1", "isoform_ac": "E9PXK8-1", "locus": { "end_pos": 50909829, "start_pos": 50942710, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000164311", "id": "ENSMUST00000164311", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000126628", "id": "ENSMUSP00000126628", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 85, "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKSKYGRSLKGWGIFLLFK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:385354", "resource": "KEGG Pathway", "id": "mmu:385354", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AD83#function", "annotation": "Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83#function", "id": "A2AD83", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M1Y3-1", "protein_name": "", "sequence": { "length": 703, "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGHNVWLELLKPITKQVKNPKEVVFKFIVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEEMVRKHLVQTQYLPSQACLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASEPMLDGRRRNSAVEVTFAAELEHSKPEAEAASLHPSQSSSSFTFIYADPVFNTDPEPIDFFEERSPLSSFQTNSKFVDGHTSKVSPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLMMAEESMRPDSYVDPSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFTCTFAEQEFPTVLMDQSSAERYVASESSDSESEILKTDYYSLYGKGTKSPRARIRLSSGSLQLEEEDEAISFGTPGAEDRTLLKPCNYFLA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AD83/", "id": "A2AD83", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/18855", "id": "18855", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6ZUT3-1", "protein_name": "FERM domain-containing protein 7", "sequence": { "length": 714, "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKPDYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AD83/", "id": "A2AD83", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/18855", "id": "18855", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051057", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "positive regulation of small GTPase mediated signal transduction", "id": "GO:0051057" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032091", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "negative regulation of protein binding", "id": "GO:0032091" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "regulation of neuron projection development", "id": "GO:0010975" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010592", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "positive regulation of lamellipodium assembly", "id": "GO:0010592" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AD83", "id": "A2AD83", "database": "UniProtKB" } ], "name": "negative regulation of stress fiber assembly", "id": "GO:0051497" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 31, "annotation": "n_glycosylation_sequon", "start_pos": 29 }, { "end_pos": 118, "annotation": "n_glycosylation_sequon", "start_pos": 116 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:385354", "id": "mmu:385354", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036131", "id": "ENSMUSG00000036131", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:2686379", "id": "2686379", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/DIMPPQV/", "id": "DIMPPQV", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "id": "cd14473", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13193", "id": "cd13193", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "id": "IPR029071", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "id": "IPR014352", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "id": "IPR000299", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014847", "id": "IPR014847", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018979", "id": "IPR018979", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018980", "id": "IPR018980", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019747", "id": "IPR019747", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "id": "IPR019748", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "id": "IPR019749", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "id": "IPR035963", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041788", "id": "IPR041788", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/385354", "id": "385354", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00373", "id": "PF00373", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08736", "id": "PF08736", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09379", "id": "PF09379", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09380", "id": "PF09380", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AD83", "id": "PR_A2AD83", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A2AD83", "disease": [], "mass": { "monoisotopic_mass": 80330.0, "chemical_mass": 80330.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:2686379", "name": "Frmd7", "locus": { "end_pos": 50895180, "start_pos": 50942710, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036131", "id": "ENSMUSG00000036131", "database": "Ensembl Gene" } ] } } ] }