{ "uniprot_canonical_ac": "A2A559-1", "sequence": { "length": 320, "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD" }, "uniprot_id": "PGAP3_MOUSE", "enzyme_annotation": [], "alternativenames": [ { "full": "PER1-like domain-containing protein 1", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Post-GPI attachment to proteins factor 3" }, "publication": [ { "title": "Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22227195", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709.2", "id": "NP_001028709.2", "database": "RefSeq" } ], "authors": "Murakami H, Wang Y, Hasuwa H, Maeda Y, Kinoshita T, Murakami Y", "date": "2012", "pmid": "22227195" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559#ptm_processing", "id": "A2A559-1", "database": "UniProtKB" } ], "relation": "attached", "position": 40, "glytoucan_ac": "GlcNAc...", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A559#A2A559-1", "isoform_ac": "A2A559-1", "locus": { "end_pos": 98390041, "start_pos": 98400395, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000090827", "id": "ENSMUST00000090827", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000088337", "id": "ENSMUSP00000088337", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 320, "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD" } }, { "url": "https://www.uniprot.org/uniprot/A2A559#A2A559-2", "isoform_ac": "A2A559-2", "locus": { "end_pos": 98390041, "start_pos": 98400395, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000128897", "id": "ENSMUST00000128897", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119668", "id": "ENSMUSP00000119668", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 269, "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:320655", "resource": "KEGG Pathway", "id": "mmu:320655", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A559#function", "annotation": "Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559#function", "id": "A2A559", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709.2", "annotation": "The response of T cells was enhanced in Pgap3 knockout mice in both in vitro and in vivo studies, including alloreactive response, antigen-specific immune response, and experimental autoimmune encephalomyelitis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709.2", "id": "NP_001028709.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B1WBW5-1", "protein_name": "Post-GPI attachment to proteins factor 3", "sequence": { "length": 320, "sequence": "MARRTAPLLLLTLAVGLAGSSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWLTVGLYLQEGYRVPQFHGKWPFSRFLFIQEPASALASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPTVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNHRRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESEAMFKLD" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A559/", "id": "A2A559", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/5484", "id": "5484", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q96FM1-1", "protein_name": "Post-GPI attachment to proteins factor 3", "sequence": { "length": 320, "sequence": "MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A559/", "id": "A2A559", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/5484", "id": "5484", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709.2", "ac": "NP_001028709.2", "name": "post-GPI attachment to proteins factor 3 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016788", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "hydrolase activity, acting on ester bonds", "id": "GO:0016788" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "intrinsic component of endoplasmic reticulum membrane", "id": "GO:0031227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006505", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "GPI anchor metabolic process", "id": "GO:0006505" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559", "database": "UniProtKB" } ], "name": "GPI anchor biosynthetic process", "id": "GO:0006506" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 42, "annotation": "n_glycosylation_sequon", "start_pos": 40 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:320655", "id": "mmu:320655", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038208", "id": "ENSMUSG00000038208", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:2444461", "id": "2444461", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/RFLGMQE/", "id": "RFLGMQE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007217", "id": "IPR007217", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/320655", "id": "320655", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF04080", "id": "PF04080", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13148", "id": "PTHR13148", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A559", "id": "PR_A2A559", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A2A559", "disease": [], "mass": { "monoisotopic_mass": 36528.0, "chemical_mass": 36528.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:2444461", "name": "Pgap3", "locus": { "end_pos": 98388677, "start_pos": 98400490, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038208", "id": "ENSMUSG00000038208", "database": "Ensembl Gene" } ] } } ] }