{
    "uniprot_canonical_ac": "A1YPR0-1", 
    "sequence": {
        "length": 619, 
        "sequence": "MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAGNVKHILNAARMLEIQCIVNVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEEEEDDDDDTEDFADQENLPDPQDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGHLGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKNRKIKEEEKEELPPPPPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGGLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCTICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPAPDKAAFVMPPALGEVGGHLGGAAVCLPGPSPAKHFLAAPKGALSLQELERQFEETQMKLFGRAQLEAERNAGGLLAFALAENVAAARPYFPLPDPWAAGLAGLPGLAGLNHVASMSEANN"
    }, 
    "uniprot_id": "ZBT7C_HUMAN", 
    "enzyme_annotation": [], 
    "alternativenames": [
        {
            "full": "Zinc finger and BTB domain-containing protein 36", 
            "short": ""
        }, 
        {
            "full": "Affected by papillomavirus DNA integration in ME180 cells protein 1", 
            "short": "APM-1"
        }, 
        {
            "full": "Zinc finger protein 857C", 
            "short": ""
        }
    ], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Zinc finger and BTB domain-containing protein 7C"
    }, 
    "publication": [
        {
            "title": "APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/9427755", 
            "journal": "EMBO J.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YPR0/publications", 
                    "id": "A1YPR0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Korn B., Lichter P., Weitz S., Reuter S., Geisen C., Delius H., Schwarz E., Vogt M., Bartelmann M., Kahn T., Napierski I.", 
            "date": "1998", 
            "pmid": "9427755"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 617, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0108", 
            "annotation": "Somatic mutation in Ovarian cancer (DOID:2394) with frequency of 1/93 (0.0108)", 
            "sequence_org": "A", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "T", 
            "subjects_tested": "93", 
            "end_pos": 617, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 611, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "V", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "M", 
            "subjects_tested": "50", 
            "end_pos": 611, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 593, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "D", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "50", 
            "end_pos": 593, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 501, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.0200", 
            "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", 
            "sequence_org": "D", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "Y", 
            "subjects_tested": "50", 
            "end_pos": 501, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1YPR0#A1YPR0-1", 
            "isoform_ac": "A1YPR0-1", 
            "locus": {
                "end_pos": 48029263, 
                "start_pos": 48041107, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000590800", 
                        "id": "ENST00000590800", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000467877", 
                        "id": "ENSP00000467877", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 619, 
                "sequence": "MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAGNVKHILNAARMLEIQCIVNVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEEEEDDDDDTEDFADQENLPDPQDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGHLGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKNRKIKEEEKEELPPPPPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGGLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCTICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPAPDKAAFVMPPALGEVGGHLGGAAVCLPGPSPAKHFLAAPKGALSLQELERQFEETQMKLFGRAQLEAERNAGGLLAFALAENVAAARPYFPLPDPWAAGLAGLPGLAGLNHVASMSEANN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YPR0#B2RG53-1", 
            "isoform_ac": "B2RG53-1", 
            "locus": {
                "end_pos": 48041054, 
                "start_pos": 48041107, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000588149", 
                        "id": "ENST00000588149", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000468814", 
                        "id": "ENSP00000468814", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 18, 
                "sequence": "MANDIDELIGIPFPNHSS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YPR0#B2RG76-1", 
            "isoform_ac": "B2RG76-1", 
            "locus": {
                "end_pos": 48041063, 
                "start_pos": 48041107, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000591526", 
                        "id": "ENST00000591526", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000468752", 
                        "id": "ENSP00000468752", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 15, 
                "sequence": "MANDIDELIGIPFPN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YPR0#A0A1B0GXF8-1", 
            "isoform_ac": "A0A1B0GXF8-1", 
            "locus": {
                "end_pos": 48040910, 
                "start_pos": 48041107, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000590437", 
                        "id": "ENST00000590437", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000467323", 
                        "id": "ENSP00000467323", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 66, 
                "sequence": "MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YPR0#B2RG63-1", 
            "isoform_ac": "B2RG63-1", 
            "locus": {
                "end_pos": 48041033, 
                "start_pos": 48041107, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000588970", 
                        "id": "ENST00000588970", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000468502", 
                        "id": "ENSP00000468502", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 25, 
                "sequence": "MANDIDELIGIPFPNHSSEVLCSLN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:201501", 
            "resource": "KEGG Pathway", 
            "id": "hsa:201501", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1YPR0#function", 
            "annotation": "May be a tumor suppressor gene.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YPR0#function", 
                    "id": "A1YPR0", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8VCZ7-1", 
            "protein_name": "Zinc finger and BTB domain-containing protein 7C", 
            "sequence": {
                "length": 619, 
                "sequence": "MANDIDELIGIPFPNHSSEVLCSLNEQRHAGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGSLASQPYVYEIDFVQPEALAAILEFAYTSTLTITASNVKHILNAARMLEIQCIVNVCLEIMEPGGSVGEEDDKEEEDEDDDDEDEDDEEEEEEEEEEEEDDPEDFADQENLPDPQDITCPQSPSKTDHLTEKDYSDTPRDFPDSFQPGSPGHLGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPEFFPHLWPGGFGAFAQLPEQPMDSGPLDLVIKNRKIKEEDKEELAPPPPPPFSSDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGSLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCSICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPSADKAAFVMPPALGDVGGHLGGTAVCLPGPSPAKHFLASPKGTLSLQELERQFEETQMKLFGRAQLEAERNAGGLLALALAENVAATRPYFPLPDPWAAGLAGLPGLTGLNHVASMSEANN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/17070", 
                    "id": "17070", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "B2GV04-1", 
            "protein_name": "", 
            "sequence": {
                "length": 619, 
                "sequence": "MANDIDELIGIPFPNHSSEVLCSLNEQRHAGLLCDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGNLASQPYVYEIDFVQPEALAAILEFAYTSTLTITASNVKHILNAARMLEIQCIVNVCLEIMEPGGNVGEEDDKEEEDDDEDDDDEDDEEEEEEEEEEEEDDTEDFADQENLPDPQDINCPQSPSKTDCLTEKDYSDTPRDFPDSFQPESPGHLGVIRDFSIESLLRENLYPKASIPDRRPSLSPFAPEFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKDRKIKEEEKEELAPPPPPPFSSDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGSLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCSICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPSADKAAFVMPPALGDVGGHLGGTAVCLPGPSPAKHFLASPKGTLSLQELERQFEETQMKLFGRAQLEAERNAGGLLALALAENVAATRPYFPLPDPWAAGLAGLPGLTGLNHVASMSEANN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/17070", 
                    "id": "17070", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleic acid binding", 
                        "id": "GO:0003676"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell population proliferation", 
                        "id": "GO:0008285"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of fat cell differentiation", 
                        "id": "GO:0045600"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903025", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YPR0", 
                                "id": "A1YPR0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of RNA polymerase II regulatory region sequence-specific DNA binding", 
                        "id": "GO:1903025"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 17, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 15
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:201501", 
            "id": "hsa:201501", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184828", 
            "id": "ENSG00000184828", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=31700", 
            "id": "31700", 
            "database": "HGNC"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DQPYVYE/", 
            "id": "DQPYVYE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", 
            "id": "IPR016024", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", 
            "id": "IPR000210", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", 
            "id": "IPR011333", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", 
            "id": "IPR013087", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", 
            "id": "IPR036236", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZBTB7C", 
            "id": "ZBTB7C", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/201501", 
            "id": "201501", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00651", 
            "id": "PF00651", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00096", 
            "id": "PF00096", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1YPR0", 
            "id": "PR_A1YPR0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A1YPR0", 
            "id": "NX_A1YPR0", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A1YPR0*", 
            "id": "A1YPR0", 
            "database": "IntAct"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Up", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1YPR0", 
                    "id": "A1YPR0", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
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}