{ "uniprot_canonical_ac": "A1L020-1", "sequence": { "length": 520, "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS" }, "uniprot_id": "MEX3A_HUMAN", "enzyme_annotation": [], "alternativenames": [ { "full": "RING finger and KH domain-containing protein 4", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020", "id": "A1L020", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "RNA-binding protein MEX3A" }, "publication": [ { "title": "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17267406", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020/publications", "id": "A1L020", "database": "UniProtKB" } ], "authors": "Billaud M., Le Hir H., Seraphin B., Duret L., Buchet-Poyau K., Courchet J., Domon-Dell C., Freund J.-N., Scoazec J.-Y.", "date": "2007", "pmid": "17267406" } ], "glycosylation": [], "mutation": [ { "start_pos": 368, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L020", "id": "A1L020", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", "sequence_org": "Y", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 368, "type": "Point mutation" }, { "start_pos": 349, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L020", "id": "A1L020", "database": "BioMuta" } ], "frequency": "0.0139", "annotation": "Somatic mutation in Breast cancer (DOID:1612) with frequency of 1/72 (0.0139)", "sequence_org": "S", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "C", "subjects_tested": "72", "end_pos": 349, "type": "Point mutation" }, { "start_pos": 210, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L020", "id": "A1L020", "database": "BioMuta" } ], "frequency": "0.1429", "annotation": "Somatic mutation in Hematologic cancer (DOID:2531) with frequency of 1/7 (0.1429)", "sequence_org": "S", "disease": { "doid": "2531", "url": "http://disease-ontology.org/term/DOID:2531", "icd10": "", "name": "Hematologic cancer" }, "sequence_mut": "P", "subjects_tested": "7", "end_pos": 210, "type": "Point mutation" }, { "start_pos": 180, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L020", "id": "A1L020", "database": "BioMuta" } ], "frequency": "0.0139", "annotation": "Somatic mutation in Breast cancer (DOID:1612) with frequency of 1/72 (0.0139)", "sequence_org": "T", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "A", "subjects_tested": "72", "end_pos": 180, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L020#A1L020-1", "isoform_ac": "A1L020-1", "locus": { "end_pos": 156076577, "start_pos": 156081998, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000532414", "id": "ENST00000532414", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000432845", "id": "ENSP00000432845", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 520, "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:92312", "resource": "KEGG Pathway", "id": "hsa:92312", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1L020#function", "annotation": "RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020#function", "id": "A1L020", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "G3UYU0-1", "protein_name": "", "sequence": { "length": 520, "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAAPAAPSAAPAAQTPQPPTAPKGANDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNSDGDFLAGSPDAALDSRYSDAWRVHAPGCKPLSTFRQNSLGCIGECGVDSAFEAPRLSEQGGDFGYSGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSAKARAGPPGAHRSPATSAGPEQLTGLPRRPPGEPLQGFSKLGTGGLRSPGSGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18950", "id": "18950", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1L020/", "id": "A1L020", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "A0A0G2KAA1-1", "protein_name": "RING-type domain-containing protein", "sequence": { "length": 420, "sequence": "PQPPTPPRHPGASKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNSDGDFLAGSPDAALDSRYSDAWRVHAPGCKPLSTFRQNSLGCIGECGVDSAFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSAKARAGPPGAHRSPATSAGPEQLTGLPRRPPGEPLQGFSKLGAGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1L020/", "id": "A1L020", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087194.1", "ac": "NP_001087194.1", "name": "RNA-binding protein MEX3A", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020", "id": "A1L020", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020", "id": "A1L020", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020", "id": "A1L020", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020", "id": "A1L020", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L020", "id": "A1L020", "database": "UniProtKB" } ], "name": "P-body", "id": "GO:0000932" } ], "total": 3, "name": "Cellular Component" } ] }, "site_annotation": [ { "end_pos": 133, "annotation": "n_glycosylation_sequon", "start_pos": 131 }, { "end_pos": 210, "annotation": "n_glycosylation_sequon", "start_pos": 208 }, { "end_pos": 399, "annotation": "n_glycosylation_sequon", "start_pos": 397 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:92312", "id": "hsa:92312", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33482", "id": "33482", "database": "HGNC" }, { "url": "https://omabrowser.org/oma/group/RICELNH/", "id": "RICELNH", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "id": "IPR004087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004088", "id": "IPR004088", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "id": "IPR036612", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": "IPR001841", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MEX3A", "id": "MEX3A", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/92312", "id": "92312", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00013", "id": "PF00013", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L020", "id": "PR_A1L020", "database": "PRO" }, { "url": "https://www.nextprot.org/entry/NX_A1L020", "id": "NX_A1L020", "database": "neXtProt" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A1L020*", "id": "A1L020", "database": "IntAct" } ], "expression_disease": [ { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L020", "id": "A1L020", "database": "BioXpress" } ] } ], "uniprot_ac": "A1L020", "disease": [], "mass": { "monoisotopic_mass": 54173.0, "chemical_mass": 54173.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000254726", "id": "ENSG00000254726", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33482", "name": "MEX3A", "locus": { "end_pos": 156072013, "start_pos": 156081998, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000254726", "id": "ENSG00000254726", "database": "Ensembl Gene" } ] } } ] }