{ "uniprot_canonical_ac": "A1E960-1", "sequence": { "length": 273, "sequence": "MKIIILLGLIGASSSAPLISQRLLSASNSHELLLNLNNGQLLPLQFQGAFNSWIPPFPGFLQQQQAQVSGRPQFTLSTLESFAGLFPNQIPLSRQVGLAQGGQAGQPDLSQQQTPPQTQQSASPMSYVVPVKVPQDQTQMFQYYPVYMLLPWEQPQTVTSSPQHTGQQLFEEQIPFYNQFGFAPPQAEPGVPGGQQHLAFDSFVGTAPETPGMPVEGSLLYPQKEPISFKHDNAGVFMPTTSPKPSTDNFFTSGIDPTIAPEQKVKTDSLREP" }, "uniprot_id": "ODAM_MOUSE", "enzyme_annotation": [], "alternativenames": [ { "full": "Apin", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Odontogenic ameloblast-associated protein" }, "publication": [ { "title": "Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17647262", "journal": "J. Cell. Biochem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960/publications", "id": "A1E960", "database": "UniProtKB" } ], "authors": "Smith C.E., St Arnaud R., Moffatt P., Nanci A.", "date": "2008", "pmid": "17647262" } ], "glycosylation": [ { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 241, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 252, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 118, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 247, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 240, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 258, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 114, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 159, "glytoucan_ac": "GalNAc...", "type": "O-linked" }, { "residue": "Thr", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#ptm_processing", "id": "A1E960-1", "database": "UniProtKB" } ], "relation": "attached", "position": 267, "glytoucan_ac": "GalNAc...", "type": "O-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1E960#A1E960-1", "isoform_ac": "A1E960-1", "locus": { "end_pos": 87885712, "start_pos": 87892709, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000129757", "id": "ENSMUST00000129757", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117898", "id": "ENSMUSP00000117898", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 273, "sequence": "MKIIILLGLIGASSSAPLISQRLLSASNSHELLLNLNNGQLLPLQFQGAFNSWIPPFPGFLQQQQAQVSGRPQFTLSTLESFAGLFPNQIPLSRQVGLAQGGQAGQPDLSQQQTPPQTQQSASPMSYVVPVKVPQDQTQMFQYYPVYMLLPWEQPQTVTSSPQHTGQQLFEEQIPFYNQFGFAPPQAEPGVPGGQQHLAFDSFVGTAPETPGMPVEGSLLYPQKEPISFKHDNAGVFMPTTSPKPSTDNFFTSGIDPTIAPEQKVKTDSLREP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:69592", "resource": "KEGG Pathway", "id": "mmu:69592", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1E960#function", "annotation": "Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960#function", "id": "A1E960", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A1E959-1", "protein_name": "Odontogenic ameloblast-associated protein", "sequence": { "length": 279, "sequence": "MKIIILLGFLGATLSAPLIPQRLMSASNSNELLLNLNNGQLLPLQLQGPLNSWIPPFSGILQQQQQAQIPGLSQFSLSALDQFAGLLPNQIPLTGEASFAQGAQAGQVDPLQLQTPPQTQPGPSHVMPYVFSFKMPQEQGQMFQYYPVYMVLPWEQPQQTVPRSPQQTRQQQYEEQIPFYAQFGYIPQLAEPAISGGQQQLAFDPQLGTAPEIAVMSTGEEIPYLQKEAINFRHDSAGVFMPSTSPKPSTTNVFTSAVDQTITPELPEEKDKTDSLREP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/49511", "id": "49511", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q3HS83-1", "protein_name": "Odontogenic ameloblast-associated protein", "sequence": { "length": 278, "sequence": "MKIIILLGLIGATSSAPLITQRLLSASNSHELLLNLNNGQLLPLQFQSAFNSWIPPFPGLLQQQQQQAQVSGHPQFPLSTLESFAGLFPNQIPFSRQVGFAQGGQAGQPDFSQQQTPSQTQQASPMSYVVPVKVPQDQTQMFQYYPVYMLLPWEQPQQTVTSSPQQTGQQLYEEQIPFYNQFGFVPQQAEPGVPGGQQHLVLDSFVGTAPETPGMPAVEGPLYPQKEPIGFKQDNVGVSTPSTSPKPDTGNFFTSEINPTIAPLLPEQKVNADSLREP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/49511", "id": "49511", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099512", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "supramolecular fiber", "id": "GO:0099512" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "extracellular region", "id": "GO:0005576" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "cell periphery", "id": "GO:0071944" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "positive regulation of protein phosphorylation", "id": "GO:0001934" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "inflammatory response", "id": "GO:0006954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "positive regulation of gene expression", "id": "GO:0010628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "positive regulation of GTPase activity", "id": "GO:0043547" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "response to wounding", "id": "GO:0009611" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042475", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "odontogenesis of dentin-containing tooth", "id": "GO:0042475" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031214", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "biomineral tissue development", "id": "GO:0031214" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060054", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1E960", "id": "A1E960", "database": "UniProtKB" } ], "name": "positive regulation of epithelial cell proliferation involved in wound healing", "id": "GO:0060054" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:69592", "id": "mmu:69592", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000009580", "id": "ENSMUSG00000009580", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:1916842", "id": "1916842", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/FPNQIPF/", "id": "FPNQIPF", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026802", "id": "IPR026802", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/69592", "id": "69592", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF15424", "id": "PF15424", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16237", "id": "PTHR16237", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1E960", "id": "PR_A1E960", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A1E960", "disease": [], "mass": { "monoisotopic_mass": 29820.0, "chemical_mass": 29820.0 }, "expression_tissue": [], "gene": [ { "url": "http://www.informatics.jax.org/marker/MGI:1916842", "name": "Odam", "locus": { "end_pos": 87894174, "start_pos": 87885029, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000009580", "id": "ENSMUSG00000009580", "database": "Ensembl Gene" } ] } } ] }