{
    "uniprot_canonical_ac": "A1A547-1", 
    "sequence": {
        "length": 347, 
        "sequence": "MLVSWDHPKMLPRLLGFLALSLLACGNPTIVSRKEWGASSLTCRVPLSLPVPYLIIEQVTRMQCQDQITCSQVVRVLQSQYVHNKGWCDIAFNFLVGDDGKVYEGVGWYVQGLHTQGYNNVSLGIAFFGSKIGSPSPAALSATEDLIFFAIQNGYLSPKYIQPFLLKEETCLVPQHSEIPKKACPNITPRSAWEARETHCPQMNLPAKFVIIIHTAGKSCNESADCLVRVRDTQSFHIDNQDFCDIAYHFLVGQDGEVYEGVGWNIEGSHTYGYNDIALGIAFMGNFVEKPPNEASLKAAQSLIQCAVAKGYLTSNYLLMGHSDVSNILSPGQALYNIIKTWPHFKH"
    }, 
    "uniprot_id": "PGRP3_MOUSE", 
    "enzyme_annotation": [], 
    "alternativenames": [
        {
            "full": "Peptidoglycan recognition protein I-alpha", 
            "short": "PGRP-I-alpha"
        }, 
        {
            "full": "Peptidoglycan recognition protein intermediate alpha", 
            "short": ""
        }
    ], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A547", 
                    "id": "A1A547", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Peptidoglycan recognition protein 3"
    }, 
    "publication": [
        {
            "title": "Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/26332373", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130.2", 
                    "id": "NP_997130.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Gowda RN, Redfern R, Frikeche J, Pinglay S, Foster JW, Lema C, Cope L, Chakravarti S", 
            "date": "2015", 
            "pmid": "26332373"
        }, 
        {
            "title": "Murine peptidoglycan recognition proteins PglyrpIalpha and PglyrpIbeta are encoded in the epidermal differentiation complex and are expressed in epidermal and hematopoietic tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15177568", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A547/publications", 
                    "id": "A1A547", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Hsu Y.-M., Thill G., Carulli J.P., Crowell T., Gardner H., Allaire N., Murray B., Mathur P.", 
            "date": "2004", 
            "pmid": "15177568"
        }
    ], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A547#ptm_processing", 
                    "id": "A1A547-1", 
                    "database": "UniProtKB"
                }
            ], 
            "relation": "attached", 
            "position": 120, 
            "glytoucan_ac": "GlcNAc...", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A547#A1A547-1", 
            "isoform_ac": "A1A547-1", 
            "locus": {
                "end_pos": 92014627, 
                "start_pos": 92031560, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000047660", 
                        "id": "ENSMUST00000047660", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000035737", 
                        "id": "ENSMUSP00000035737", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 347, 
                "sequence": "MLVSWDHPKMLPRLLGFLALSLLACGNPTIVSRKEWGASSLTCRVPLSLPVPYLIIEQVTRMQCQDQITCSQVVRVLQSQYVHNKGWCDIAFNFLVGDDGKVYEGVGWYVQGLHTQGYNNVSLGIAFFGSKIGSPSPAALSATEDLIFFAIQNGYLSPKYIQPFLLKEETCLVPQHSEIPKKACPNITPRSAWEARETHCPQMNLPAKFVIIIHTAGKSCNESADCLVRVRDTQSFHIDNQDFCDIAYHFLVGQDGEVYEGVGWNIEGSHTYGYNDIALGIAFMGNFVEKPPNEASLKAAQSLIQCAVAKGYLTSNYLLMGHSDVSNILSPGQALYNIIKTWPHFKH"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:242100", 
            "resource": "KEGG Pathway", 
            "id": "mmu:242100", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157", 
            "resource": "Reactome", 
            "id": "R-MMU-6803157", 
            "name": "Antimicrobial peptides"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A547#function", 
            "annotation": "Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A547#function", 
                    "id": "A1A547", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130.2", 
            "annotation": "Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130.2", 
                    "id": "NP_997130.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130.2", 
            "annotation": "Pglyrp3 deficiency resulted in colitis-predisposing intestinal microflora and increased intestinal ATP", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130.2", 
                    "id": "NP_997130.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q96LB9-1", 
            "protein_name": "Peptidoglycan recognition protein 3", 
            "sequence": {
                "length": 341, 
                "sequence": "MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQSVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAFFGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/71559", 
                    "id": "71559", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1A547/", 
                    "id": "A1A547", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "D3ZYV3-1", 
            "protein_name": "", 
            "sequence": {
                "length": 346, 
                "sequence": "LVSWDHLKMLCRLLAFSALSLVACGSPTIVSRKVWGASSLTCRVPLSLPVPYLIIEQVTRMQCQDQTSCSQVLRVLHSHYVHNKGWCDVAFNFLVGNDGKVYEGVGWHVQGLHTQGYNNVSLGIAFFGSKIGSPSPAALSATEDLIFFAILNGYLSPKYIQPFLLKEETCLVPQHSEIPKKACPNIIPRTAWEARETHCSQMNLPAKFVIIIHTAGESCNESADCLIRVRDTQSFHMDKQDFCDIAYHFLVGQDGVVYEGVGWTIEGSHTYGYNDIALGIAFMGNFVEKPPNEASLEAAQSLIQCAVAMGYLASNYLLMGHSDVSNILSPGQALYNIIKTWPHFKH"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A1A547/", 
                    "id": "A1A547", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130.2", 
        "ac": "NP_997130.2", 
        "name": "peptidoglycan recognition protein 3 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042834", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidoglycan binding", 
                        "id": "GO:0042834"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008745", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "N-acetylmuramoyl-L-alanine amidase activity", 
                        "id": "GO:0008745"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "zinc ion binding", 
                        "id": "GO:0008270"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein heterodimerization activity", 
                        "id": "GO:0046982"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016019", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidoglycan receptor activity", 
                        "id": "GO:0016019"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein-containing complex", 
                        "id": "GO:0032991"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032827", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of natural killer cell differentiation involved in immune response", 
                        "id": "GO:0032827"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044117", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "growth of symbiont in host", 
                        "id": "GO:0044117"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051714", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cytolysis in other organism", 
                        "id": "GO:0051714"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "innate immune response", 
                        "id": "GO:0045087"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to Gram-positive bacterium", 
                        "id": "GO:0050830"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", 
                        "id": "GO:0061844"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016045", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "detection of bacterium", 
                        "id": "GO:0016045"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032689", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of interferon-gamma production", 
                        "id": "GO:0032689"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "killing of cells of other organism", 
                        "id": "GO:0031640"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019730", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antimicrobial humoral response", 
                        "id": "GO:0019730"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009253", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A547", 
                                "id": "A1A547", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidoglycan catabolic process", 
                        "id": "GO:0009253"
                    }
                ], 
                "total": 11, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 122, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 120
        }, 
        {
            "end_pos": 188, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 186
        }, 
        {
            "end_pos": 223, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 221
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:242100", 
            "id": "mmu:242100", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157", 
            "id": "R-MMU-6803157", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000042244", 
            "id": "ENSMUSG00000042244", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2685266", 
            "id": "2685266", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/WHIQGSH/", 
            "id": "WHIQGSH", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06583", 
            "id": "cd06583", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002502", 
            "id": "IPR002502", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006619", 
            "id": "IPR006619", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015510", 
            "id": "IPR015510", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036505", 
            "id": "IPR036505", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/242100", 
            "id": "242100", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01510", 
            "id": "PF01510", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11022", 
            "id": "PTHR11022", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A547", 
            "id": "PR_A1A547", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1A547", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 38503.0, 
        "chemical_mass": 38503.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2685266", 
            "name": "Pglyrp3", 
            "locus": {
                "end_pos": 92031582, 
                "start_pos": 92014583, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000042244", 
                        "id": "ENSMUSG00000042244", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}