{ "uniprot_canonical_ac": "A0JPK3-1", "sequence": { "length": 406, "sequence": "MAAKKQSKSAKALRTTVRYEDVAVSFTQEEWEYLTSTQKTLYQKVMSETFKNLTFVESKKKPQEPNPNLKDKDDDKSSTCTGVFKGGPFFFCLTCGKCFKKNTFLFNHQFPVRSRRLAVTKPQSRKALGHKPQHRGDRPFFCNLCGKTYRDASGLSRHRRAHVGYRPRSCPECGKCFRDQSEVNRHLKVHQNKKPVAGSHVKVHQNKPVASNQKQKGRVPPTTRESPAPALRHLKVIQGPVARAKARSSRASSLEVRSTSVTVARPREKVYCPYCRITFTMRTCLLNHLKIHFRRQPNQHFCCKESHSSNTLRMQKIYNCPVCDSSFRGKESLLNHLCSRRPIRLSKCWEILGHLLGYLREPLGNIFKVRESRKRRRKRISSDSSETEGPSGSDEVMEVDTDSDLS" }, "uniprot_id": "ZFP57_RAT", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Zinc finger protein 57", "short": "Zfp-57" }, "publication": [ { "title": "The genomic sequence and comparative analysis of the rat major histocompatibility complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15060004", "journal": "Genome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3/publications", "id": "A0JPK3", "database": "UniProtKB" } ], "authors": "Klages S., Lehrach H., Mueller I., Reinhardt R., Sudbrak R., Inoko H., Shiina T., Guenther E., Walter L., Himmelbauer H., Hurt P.", "date": "2004", "pmid": "15060004" }, { "title": "Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15070898", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3/publications", "id": "A0JPK3", "database": "UniProtKB" } ], "authors": "Rahman M., Zoidl G., Harris B.S., Taveggia C., Wrabetz L., Bosse F., Mueller H.W., Dean C.H., Alonso M.B., Jessen K.R., Mirsky R., Parmantier E., Zoidl C.", "date": "2004", "pmid": "15070898" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3#A0JPK3-1", "isoform_ac": "A0JPK3-1", "locus": { "end_pos": 2014535, "start_pos": 2018285, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000011704", "id": "ENSRNOT00000011704", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000011704", "id": "ENSRNOP00000011704", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 406, "sequence": "MAAKKQSKSAKALRTTVRYEDVAVSFTQEEWEYLTSTQKTLYQKVMSETFKNLTFVESKKKPQEPNPNLKDKDDDKSSTCTGVFKGGPFFFCLTCGKCFKKNTFLFNHQFPVRSRRLAVTKPQSRKALGHKPQHRGDRPFFCNLCGKTYRDASGLSRHRRAHVGYRPRSCPECGKCFRDQSEVNRHLKVHQNKKPVAGSHVKVHQNKPVASNQKQKGRVPPTTRESPAPALRHLKVIQGPVARAKARSSRASSLEVRSTSVTVARPREKVYCPYCRITFTMRTCLLNHLKIHFRRQPNQHFCCKESHSSNTLRMQKIYNCPVCDSSFRGKESLLNHLCSRRPIRLSKCWEILGHLLGYLREPLGNIFKVRESRKRRRKRISSDSSETEGPSGSDEVMEVDTDSDLS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:361783", "resource": "KEGG Pathway", "id": "rno:361783", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3#function", "annotation": "Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3#function", "id": "A0JPK3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9NU63-1", "protein_name": "Zinc finger protein 57 homolog", "sequence": { "length": 452, "sequence": "MAAGEPRSLLFFQKPVTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVARIFLHKPELITKLEQEEEQWRETRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQFVHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKRHQKIHQNQEPVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHPVKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFGEKEGLMDHWRGYKGKDLCQSSHHKCRVILGQWLGFSHDVPTMAGEEWKHGGDQSPPRIHTPRRRGLREKACKGDKTKEAVSILKHK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/7603", "id": "7603", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8C6P8-1", "protein_name": "Zinc finger protein 57", "sequence": { "length": 421, "sequence": "MAARKQSSQPSRTPVSYEDVAVSFTQEEWEYLTSTQKTLYQKVMSETFKNLTFVGSKKKPQEPSSDLQDKNEEQEKSSSCTGVFKGGPFFFCLTCGKCFKKNTFLFNHQFPVRSRRLAVTNPQSRKGKGYKAQHRGERPFFCNFCGKTYRDASGLSRHRRAHLGYRPRSCPECGKCFRDQSEVNRHLKVHQNKPAASNQAGNQASNQRLKSRVPPTTPRSQAPALKYVKVIQGPVARAKARNSGASTLNVRSNSITVVRSREKISCPYCHITFTMRTCLLTHLKIHFRRQPNQHFCCKESAHSSNTLRMQKIYTCPVCDSSFRGKESLLDHLCCQRPIRFSKCWEILGHLLGYLHEPVVLGNIFKVRDSSGKRMESRRRRRKRACTENPETEGLSGKGRVAPWEMEGATSPESPVTEEDSD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/7603", "id": "7603", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "DNA methylation involved in embryo development", "id": "GO:0043045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "regulation of transcription, DNA-templated", "id": "GO:0006355" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006349", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPK3", "id": "A0JPK3", "database": "UniProtKB" } ], "name": "regulation of gene expression by genetic imprinting", "id": "GO:0006349" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 54, "annotation": "n_glycosylation_sequon", "start_pos": 52 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:361783", "id": "rno:361783", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022730", "id": "ENSRNOG00000022730", "database": "Bgee" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1302981", "id": "1302981", "database": "RGD" }, { "url": "https://omabrowser.org/oma/group/CGKLFWS/", "id": "CGKLFWS", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "id": "cd07765", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "id": "IPR001909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "id": "IPR036051", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/361783", "id": "361783", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF01352", "id": "PF01352", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPK3", "id": "PR_A0JPK3", "database": "PRO" } ], "expression_disease": [], "uniprot_ac": "A0JPK3", "disease": [], "mass": { "monoisotopic_mass": 46588.0, "chemical_mass": 46588.0 }, "expression_tissue": [], "gene": [ { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1302981", "name": "Zfp57", "locus": { "end_pos": 2014170, "start_pos": 2020537, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000022730", "id": "ENSRNOG00000022730", "database": "Ensembl Gene" } ] } } ] }