{ "uniprot_canonical_ac": "A0AVK6-1", "sequence": { "length": 867, "sequence": "MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPVIHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAGERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENSSALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDVH" }, "uniprot_id": "E2F8_HUMAN", "enzyme_annotation": [], "alternativenames": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Transcription factor E2F8", "short": "E2F-8" }, "publication": [ { "title": "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22903062", "journal": "EMBO J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Leone G., Schulte-Merker S., Bakker W.J., Cornelissen P.W., Kent L., Liang K.H., Paciejewska M., Schaftenaar F.H., Scheele C.L., Weijts B.G., Westendorp B., de Bruin A., de Wolf C.A.", "date": "2012", "pmid": "22903062" }, { "title": "E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22802528", "journal": "Genes Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Hamard P.J., Carvajal L.A., Manfredi J.J., Tonnessen C.", "date": "2012", "pmid": "22802528" }, { "title": "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18220336", "journal": "J. Proteome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Cantin G.T., Lee J.-D., Lu B., Park S.K., Xu T., Yates J.R. III, Yi W., Yates J.R., Lee J.D.", "date": "2008", "pmid": "18220336" }, { "title": "DNA-damage response control of E2F7 and E2F8.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18202719", "journal": "EMBO Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Zhao X., Fisher R., Reilly C., La Thangue N.B., Coutts A.S., Graham A.L., Zalmas L.P.", "date": "2008", "pmid": "18202719" }, { "title": "Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18194653", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Li J., Li E., Weinstein M., Leone G., Liu C.-G., Chen H.-Z., Cleghorn W., Comstock G., Gordon F., Khanizadeh M., Kornacker K., Pandit S.K., Ran C., Siddiqui H., de Bruin A.", "date": "2008", "pmid": "18194653" }, { "title": "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16179649", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Helin K., Bracken A.P., Christensen J., Cloos P., Di Stefano L., Heeran M., Klinkenberg D., Toftegaard U., Trinh E.", "date": "2005", "pmid": "16179649" }, { "title": "E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15897886", "journal": "Oncogene", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6/publications", "id": "A0AVK6", "database": "UniProtKB" } ], "authors": "Graham A., Zhao X., Fisher R., Leone G., La Thangue N.B., Maiti B., Logan N.", "date": "2005", "pmid": "15897886" } ], "glycosylation": [], "mutation": [ { "start_pos": 821, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AVK6", "id": "A0AVK6", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", "sequence_org": "E", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "*", "subjects_tested": "50", "end_pos": 821, "type": "Point mutation" }, { "start_pos": 803, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AVK6", "id": "A0AVK6", "database": "BioMuta" } ], "frequency": "0.0200", "annotation": "Somatic mutation in Thyroid cancer (DOID:1781) with frequency of 1/50 (0.0200)", "sequence_org": "T", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "I", "subjects_tested": "50", "end_pos": 803, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6#A0AVK6-1", "isoform_ac": "A0AVK6-1", "locus": { "end_pos": 19224661, "start_pos": 19240121, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000620009", "id": "ENST00000620009", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000481103", "id": "ENSP00000481103", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 867, "sequence": "MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPVIHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAGERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENSSALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDVH" } }, { "url": "https://www.uniprot.org/uniprot/A0AVK6#E9PMT9-1", "isoform_ac": "E9PMT9-1", "locus": { "end_pos": 19237348, "start_pos": 19240121, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000532666", "id": "ENST00000532666", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000437326", "id": "ENSP00000437326", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 139, "sequence": "MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:79733", "resource": "KEGG Pathway", "id": "hsa:79733", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116", "resource": "Reactome", "id": "R-HSA-6804116", "name": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6#function", "annotation": "Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6#function", "id": "A0AVK6", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q58FA4-1", "protein_name": "Transcription factor E2F8", "sequence": { "length": 860, "sequence": "MENQKENLFSEPHKRGLMKSPLHPSSKANMVLAEIQPDLGPLTTPTKPKEVSQGEPWTPTANLKMLISAVSPEIRSRDQKRGLSDNRSALPEARDCLHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPKYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLTKTLGTLKSVGEENKYAEQIMMIKRKEYEQEFDFIKSCGIEDHVIKSHTGQNGHSDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEIAAKILIGEDHVEDLDKSKYKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNNSGSSPIMPLPASLEAEQSAKENCAKNLFSTRGKPSFTRHPSLIKLVKSIENDRRKISSAPSSPVKSNKAESSQNSPPVPNKMAQLAAICKMQLEEQSSEPRKKVKVNLARSGHYKPLAPLDPTVNTELELLTPSLIQPLGVVPLIPSPLSSAVPVILPQAPSGPSYAIYLQPAQAQMLTPPPGLSPTVCPTQPSNATGSKDPTDAPAEKTATDAATTGSLQPAPERHGAKHRSKETTGDRGTKRMITAEDSGPSSVKKPKEDLKALENVPTPTPLFPSGYLIPLTQCSSLGPDSVLSNTENSGTPSPNHRIYGSPIAGVIPVASSELTAVNFPPFHVTPLKLMVSPTSMAAVPVGNSPALNSGHPAPAQNPSSAIVNFTLQHLGLISPGVQMSASPGPGAGTVPVSPRVEADNLSSRQRRATNHDSPVLGQSQLNGQPVAGTGAQQPVPVTPKGSQLVAENFFRTPGGPTKPTSSPYTDFDGANKTSFGTLFVPQRKLEVSTEDIH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11654", "id": "11654", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "proximal promoter sequence-specific DNA binding", "id": "GO:0000987" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription factor complex", "id": "GO:0090575" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "positive regulation of DNA endoreduplication", "id": "GO:0032877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "cell cycle comprising mitosis without cytokinesis", "id": "GO:0033301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060718", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "chorionic trophoblast cell differentiation", "id": "GO:0060718" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "cell population proliferation", "id": "GO:0008283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001890", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "placenta development", "id": "GO:0001890" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest", "id": "GO:0006977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "sprouting angiogenesis", "id": "GO:0002040" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032466", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "negative regulation of cytokinesis", "id": "GO:0032466" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070365", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "hepatocyte differentiation", "id": "GO:0070365" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060707", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AVK6", "id": "A0AVK6", "database": "UniProtKB" } ], "name": "trophoblast giant cell differentiation", 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