{ "uniprot_canonical_ac": "A0AV02-1", "sequence": { "length": 714, "sequence": "MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY" }, "uniprot_id": "S12A8_HUMAN", "enzyme_annotation": [], "alternativenames": [ { "full": "Cation-chloride cotransporter 9", "short": "" } ], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Solute carrier family 12 member 8" }, "publication": [ { "title": "Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16297188", "journal": "J. Invest. Dermatol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02/publications", "id": "A0AV02", "database": "UniProtKB" } ], "authors": "Baumann C., Kuester W., Burkhardt H., Reis A., Traupe H., Lascorz J., Hueffmeier U., Boehm B., Kelsch R., Schuermeier-Horst F., Staender M.", "date": "2005", "pmid": "16297188" }, { "title": "Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11863360", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02/publications", "id": "A0AV02", "database": "UniProtKB" } ], "authors": "See C.G., Riley J., Robinson P., Inerot A., Plumpton M., Enlund F., Martinsson T., Samuelsson L., Swanbeck G., Wahlstrom J., Cantone K., Chadha S., Christodolou C., Enerback C., Hewett D., Matthews P., Montgomery D., Polding J., Purvis I., Roses A., Smart D.", "date": "2002", "pmid": "11863360" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02#ptm_processing", "id": "A0AV02-1", "database": "UniProtKB" } ], "relation": "attached", "position": 221, "glytoucan_ac": "GlcNAc...", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0AV02#A0AV02-1", "isoform_ac": "A0AV02-1", "locus": { "end_pos": 125083893, "start_pos": 125211349, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000469902", "id": "ENST00000469902", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000418783", "id": "ENSP00000418783", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 714, "sequence": "MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#H7C5B1-1", "isoform_ac": "H7C5B1-1", "locus": { "end_pos": 125177828, "start_pos": 125190525, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000473262", "id": "ENST00000473262", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000419424", "id": "ENSP00000419424", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 160, "sequence": "XQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQVPCISPALLNPSRICWASGISGLCEEFQLRCFWPCWALTSQVSNG" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#A0AV02-2", "isoform_ac": "A0AV02-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 743, "sequence": "MLPLERTITYRDMSSFIQVKNHFNVVNVTCVSYRSTCFRDMRRFILDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#C9IZN2-1", "isoform_ac": "C9IZN2-1", "locus": { "end_pos": 125177933, "start_pos": 125190476, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000462437", "id": "ENST00000462437", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000418636", "id": "ENSP00000418636", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 112, "sequence": "MWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAES" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#A0AV02-3", "isoform_ac": "A0AV02-3", "locus": { "end_pos": 125083893, "start_pos": 125120825, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000430155", "id": "ENST00000430155", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000415713", "id": "ENSP00000415713", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 515, "sequence": "MRRAAAGGLAVGQLPGEGPAGEEGAALGKAMRGGGCSPHSPSGCLSGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#H7C5L2-1", "isoform_ac": "H7C5L2-1", "locus": { "end_pos": 125110273, "start_pos": 125190450, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000479826", "id": "ENST00000479826", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000420197", "id": "ENSP00000420197", "database": "Ensembl Peptide" } ] }, "sequence": { "length": 207, "sequence": "LGWCVHILHDQHLWGCALPEDWLAGGKHRSAPGHVPGVLRHPGGPRHGAVWHWRRGAQQHRQRWRLLHDLLGPGWADGRHHRAALCVWTEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCM" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#A0AV02-4", "isoform_ac": "A0AV02-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 375, "sequence": "MAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEGSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV02#A0AV02-5", "isoform_ac": "A0AV02-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "length": 308, "sequence": "MCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:84561", "resource": "KEGG Pathway", "id": "hsa:84561", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0AV02#function", "annotation": "Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02#function", "id": "A0AV02", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8CJI3-1", "protein_name": "Solute carrier family 12 member 8", "sequence": { "length": 707, "sequence": "MAQRSPQELFHEAAQQGVLARSQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGLLLVSFVILVALITVLSGIGVAEHGWMGSGGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYLTGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLSLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQSNILPEYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPADQHTPRLPSSCWVSRGFSNIIFAFLLGAVCTREALRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQDKVIPALAFLGNGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIAVDYSYFALSMAHCGLAQSPEPMPRQGPDALHCSEHLLQDKAPSYGSDTPAGSLSEGTLLEFTKDMDQLLQPIGGLESQPRSREVNQVLKSQKHKCKKDAKQTLQDSFLLDAESPLSFSMGASERLSVASCGEQESYQNQQTSRSESHDHLVPDLCTQPRANGEDFFLKCRLQEQQVQRRPSAFYVCMCNPWVSLLGALASLLIMFVIQWLYTLASMGVAALVYLYIGQASPGLYLGSASNFSFFQWMKSFLVPSCRSLRSTREQIILAPSPAKVDMAMTQAYPGQWQTSATRERYHRSSFLSREQLMPPY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11628", "id": "11628", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8VI23-1", "protein_name": "Solute carrier family 12 member 8", "sequence": { "length": 705, "sequence": "MAQRSPQELFHEAAQQGILAQPQPWWKIQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGLLLVSFVVLVALITVLSGIGVAEHGGISSGGVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYITGFAESISDLLGLGDIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQSNILPEYSPGESFFTVFGVFFPAATGVMAGFNMGGDLRDPADSVPLGSLAAVGVSWFLYIIFAFLLGAVCTREALRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQDKVIPALAFLANGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIMVDYSYFALSMAHCGLAPSPEPVPRQGPDTLHCSEHLLQDRAPSYGSDVPARSLSEGTLLEFTKDMDQFLQPIEELESRQLGSREGNNPKNQKRKGKKGAKQTLQDSFLLDPGSPLSFPTRTSERLSVAFCGEQESYQKQQTSRSESHDHLVPDLRNQPRVNREDFFLKCRLQEQEIQRRPSVFYACMCNPWVSLLGALASLLIMFVIQWLYTLASMGVAALVYFYIGQASPGLYLGSASNFSFFQWMKSFLVPSCRSLRSAQEQIILAPSPAKVDMAMTQLTQDNADFATRDRYHHSSFLSREQLMPPY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11628", "id": "11628", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015379", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "potassium:chloride symporter activity", "id": "GO:0015379" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005623", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "cell", "id": "GO:0005623" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "cell volume homeostasis", "id": "GO:0006884" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "chloride transmembrane transport", "id": "GO:1902476" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "potassium ion homeostasis", "id": "GO:0055075" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "potassium ion import across plasma membrane", "id": "GO:1990573" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV02", "id": "A0AV02", "database": "UniProtKB" } ], "name": "chloride ion homeostasis", "id": "GO:0055064" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 223, "annotation": "n_glycosylation_sequon", "start_pos": 221 }, { "end_pos": 359, "annotation": "n_glycosylation_sequon", "start_pos": 357 }, { "end_pos": 485, "annotation": "n_glycosylation_sequon", "start_pos": 483 }, { "end_pos": 563, "annotation": "n_glycosylation_sequon", "start_pos": 561 }, { "end_pos": 647, "annotation": "n_glycosylation_sequon", "start_pos": 645 } ], "crossref": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:84561", "id": "hsa:84561", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000221955", "id": "ENSG00000221955", "database": "Bgee" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=15595", "id": "15595", "database": "HGNC" }, { "url": "https://omabrowser.org/oma/group/CNRWFSL/", "id": "CNRWFSL", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "id": "IPR004841", "database": "InterPro" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC12A8", "id": "SLC12A8", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/84561", "id": "84561", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00324", "id": "PF00324", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0AV02", "id": "PR_A0AV02", "database": "PRO" }, { "url": "https://www.nextprot.org/entry/NX_A0AV02", "id": "NX_A0AV02", "database": "neXtProt" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0AV02*", "id": "A0AV02", "database": "IntAct" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV02", "id": "A0AV02", "database": "BioXpress" } ] } ], "uniprot_ac": "A0AV02", "disease": [], "mass": { "monoisotopic_mass": 78239.0, 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