{
    "uniprot_canonical_ac": "A2RT60-1", 
    "sequence": {
        "length": 483, 
        "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN"
    }, 
    "uniprot_id": "HTRA4_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "3.4.21.-", 
            "activity": ""
        }
    ], 
    "alternativenames": [
        {
            "full": "High-temperature requirement factor A4", 
            "short": ""
        }
    ], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT60", 
                    "id": "A2RT60", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Serine protease HTRA4"
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#A2RT60-1", 
            "isoform_ac": "A2RT60-1", 
            "locus": {
                "end_pos": 25025572, 
                "start_pos": 25038874, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000084031", 
                        "id": "ENSMUST00000084031", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000081044", 
                        "id": "ENSMUSP00000081044", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 483, 
                "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:330723", 
            "resource": "KEGG Pathway", 
            "id": "mmu:330723", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#function", 
            "annotation": "Serine protease.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT60#function", 
                    "id": "A2RT60", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
            "annotation": "Mice, featuring a conditional null allele of HtrA4, may provide a valuable tool to investigate the role of HtrA4 in development and pathogenesis of coronary heart disease and preeclampsia.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
                    "id": "NP_001074656.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZKF5-1", 
            "protein_name": "Serine protease HTR4", 
            "sequence": {
                "length": 488, 
                "sequence": "MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPCPDACDPTRCPPLPSCSAGSALVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPFSREPSGRAWLGTCGCAEGAEGAAVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACGDSGTTRAGRLRTKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDHKLDLALIKIEPDTDLPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/17801", 
                    "id": "17801", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "P83105-1", 
            "protein_name": "Serine protease HTRA4", 
            "sequence": {
                "length": 476, 
                "sequence": "MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RT60/", 
                    "id": "A2RT60", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/17801", 
                    "id": "17801", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
        "ac": "NP_001074656.1", 
        "name": "serine protease HTRA4 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endopeptidase activity", 
                        "id": "GO:0004175"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "serine-type endopeptidase activity", 
                        "id": "GO:0004252"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "insulin-like growth factor binding", 
                        "id": "GO:0005520"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteolysis", 
                        "id": "GO:0006508"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:330723", 
            "id": "mmu:330723", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037406", 
            "id": "ENSMUSG00000037406", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3036260", 
            "id": "3036260", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/NQQWIEV/", 
            "id": "NQQWIEV", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", 
            "id": "IPR009030", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", 
            "id": "IPR036058", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", 
            "id": "IPR001478", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", 
            "id": "IPR009003", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", 
            "id": "IPR036034", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", 
            "id": "IPR002350", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867", 
            "id": "IPR000867", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001940", 
            "id": "IPR001940", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041489", 
            "id": "IPR041489", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/330723", 
            "id": "330723", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07648", 
            "id": "PF07648", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00219", 
            "id": "PF00219", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF17820", 
            "id": "PF17820", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RT60", 
            "id": "PR_A2RT60", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 51988.0, 
        "chemical_mass": 51988.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3036260", 
            "name": "Htra4", 
            "locus": {
                "end_pos": 25024929, 
                "start_pos": 25038962, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037406", 
                        "id": "ENSMUSG00000037406", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}