{
    "uniprot_canonical_ac": "A2AS89-1", 
    "sequence": {
        "length": 358, 
        "sequence": "MLRLLRSSWARGLGSGVATWRPSAGLFRPGCPGIRQASGASDTPHHQSPSSESPVQPVGVGVCSMMRLPLQSSPEGLDAAFIGVPLDTGTSNRPGARFGPCRIREESLMLGAVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCLLIREAYQNVLAAGCIPLTLGGDQTITYPILQAVAKEHGPVGLVHVGAHTNTTDKPREEKVYHRTPFRRSVDEGLLDSKRVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCWMKSLVPLMAEVRQQMGGKPLYISFAIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV"
    }, 
    "uniprot_id": "SPEB_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "3.5.3.11", 
            "activity": "Agmatine + H(2)O = putrescine + urea."
        }, 
        {
            "ec": "3.5.3.11", 
            "activity": ""
        }
    ], 
    "alternativenames": [
        {
            "full": "Agmatine ureohydrolase", 
            "short": "AUH"
        }
    ], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS89", 
                    "id": "A2AS89", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Agmatinase, mitochondrial"
    }, 
    "publication": [
        {
            "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/23806337", 
            "journal": "Mol. Cell", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS89/publications", 
                    "id": "A2AS89", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Chen Y., Park J., Zhang Y., Zhao Y., Peng C., Tan M., Xie Z., Zwaans B.M., Lombard D.B., Dai L., Tishkoff D.X., Skinner M.E.", 
            "date": "2013", 
            "pmid": "23806337"
        }, 
        {
            "title": "Vertebrate agmatinases: what role do they play in agmatine catabolism?", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15028567", 
            "journal": "Ann. N. Y. Acad. Sci.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS89/publications", 
                    "id": "A2AS89", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Morris S.M. Jr.", 
            "date": "2003", 
            "pmid": "15028567"
        }, 
        {
            "title": "Cloning and characterization of human agmatinase.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11914032", 
            "journal": "Mol. Genet. Metab.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS89/publications", 
                    "id": "A2AS89", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Cederbaum S.D., Kim H.K., Grody W.W., Iyer R.K., Tsoa R.W.", 
            "date": "2002", 
            "pmid": "11914032"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AS89#A2AS89-1", 
            "isoform_ac": "A2AS89-1", 
            "locus": {
                "end_pos": 141746810, 
                "start_pos": 141759068, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000038161", 
                        "id": "ENSMUST00000038161", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000040853", 
                        "id": "ENSMUSP00000040853", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "length": 358, 
                "sequence": "MLRLLRSSWARGLGSGVATWRPSAGLFRPGCPGIRQASGASDTPHHQSPSSESPVQPVGVGVCSMMRLPLQSSPEGLDAAFIGVPLDTGTSNRPGARFGPCRIREESLMLGAVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCLLIREAYQNVLAAGCIPLTLGGDQTITYPILQAVAKEHGPVGLVHVGAHTNTTDKPREEKVYHRTPFRRSVDEGLLDSKRVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCWMKSLVPLMAEVRQQMGGKPLYISFAIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:75986", 
            "resource": "KEGG Pathway", 
            "id": "mmu:75986", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-351143", 
            "resource": "Reactome", 
            "id": "R-MMU-351143", 
            "name": "Agmatine biosynthesis"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074877.1", 
            "annotation": "It thus appears that mammalian AGMs form a distinct group within the family of ureahydrolases that (i) either fold in a manner distinct from other members in this family, or (ii) require accessory proteins to bind Mn(2+) in a mechanism related to that observed for the Ni(2+)-dependent urease.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074877.1", 
                    "id": "NP_001074877.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074877.1", 
            "annotation": "These findings implicate Agmat in the depressive-like phenotype of Crtc1(-/-) mice, refine current understanding of the agmatinergic system in the brain and highlight its putative role in major depression. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074877.1", 
                    "id": "NP_001074877.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q0D2L3-1", 
            "protein_name": "Agmatinase, mitochondrial", 
            "sequence": {
                "length": 353, 
                "sequence": "MLQLLKSSWVRSAGSGVVTWRASAGLFCPGTRQASDTSDTLHHPSPSSESQVQPVRVCSMMHLPLQSSPEGLDAAFVGVPLDTGTSNRPGARFGPRRIREESLMLGTVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCRLIREAYQNILATGCIPLTLGGDHTITYPILQAVAKEHGPVGLVHVGAHSNTSDKPLEDKVYHRTPFRRSVDEGLLDSKRVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCWMKSLVPLMAEIRQQMGGVPLYISFAIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/99855", 
                    "id": "99855", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2AS89/", 
                    "id": "A2AS89", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9BSE5-1", 
            "protein_name": "Agmatinase, mitochondrial", 
            "sequence": {
                "length": 352, 
                "sequence": "MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQPPSPEFVARPVGVCSMMRLPVQTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESVMLGTVNPSTGALPFQSLMVADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKHGPVGLLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCWMKSLVPLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVMGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/99855", 
                    "id": "99855", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2AS89/", 
                    "id": "A2AS89", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074877.1", 
        "ac": "NP_001074877.1", 
        "name": "agmatinase, mitochondrial precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS89", 
                                "id": "A2AS89", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008783", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS89", 
                                "id": "A2AS89", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "agmatinase activity", 
                        "id": "GO:0008783"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS89", 
                                "id": "A2AS89", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitochondrion", 
                        "id": "GO:0005739"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008295", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS89", 
                                "id": "A2AS89", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "spermidine biosynthetic process", 
                        "id": "GO:0008295"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033389", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS89", 
                                "id": "A2AS89", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "putrescine biosynthetic process from arginine, using agmatinase", 
                        "id": "GO:0033389"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 197, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 195
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:75986", 
            "id": "mmu:75986", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-351143", 
            "id": "R-MMU-351143", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040706", 
            "id": "ENSMUSG00000040706", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1923236", 
            "id": "1923236", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DTYFGAE/", 
            "id": "DTYFGAE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006035", 
            "id": "IPR006035", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023696", 
            "id": "IPR023696", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005925", 
            "id": "IPR005925", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/75986", 
            "id": "75986", 
            "database": "GeneID"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00491", 
            "id": "PF00491", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AS89", 
            "id": "PR_A2AS89", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 38255.0, 
        "chemical_mass": 38255.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1923236", 
            "name": "Agmat", 
            "locus": {
                "end_pos": 141759263, 
                "start_pos": 141746672, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000040706", 
                        "id": "ENSMUSG00000040706", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}