{ "bcoid": "GLY_000404", "title": "Human UniProtKB Xref Pharos", "description": "The Human UniProtKB Xref Pharos dataset contains human [taxid:9606] UniProtKB canonical accessions cross-referenced ...", "filename": "human_protein_xref_pharos.csv", "filetype": "csv", "categories": { "species": "Homo sapiens", "molecule": "Protein", "tags": "Pharos cross-references", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "Q8TBF5-1...", "protein_xref..." ], [ "Q8TBF4-1...", "protein_xref..." ] ], "headers": [ "uniprotkb_ca...", "xref_key..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "xref_key" }, { "type": "string", "label": "xref_id" }, { "type": "string", "label": "xref_label" } ], [ "Q8TBF5-1", "protein_xref_pharos", "Q8TBF5", "Phosphatidylinositol-glycan biosynthesis class X protein" ], [ "Q8TBF4-1", "protein_xref_pharos", "Q8TBF4", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1" ], [ "Q9NRJ4-1", "protein_xref_pharos", "Q9NRJ4", "Tubby-related protein 4" ], [ "Q9NQ79-1", "protein_xref_pharos", "Q9NQ79", "Cartilage acidic protein 1" ], [ "Q9NVL8-1", "protein_xref_pharos", "Q9NVL8", "Uncharacterized protein CCDC198" ], [ "Q9NRQ5-1", "protein_xref_pharos", "Q9NRQ5", "Single-pass membrane and coiled-coil domain-containing protein 4" ], [ "Q8IZF5-1", "protein_xref_pharos", "Q8IZF5", "Adhesion G-protein coupled receptor F3" ], [ "P30613-1", "protein_xref_pharos", "P30613", "Pyruvate kinase PKLR" ], [ "Q5H9L4-1", "protein_xref_pharos", "Q5H9L4", "Transcription initiation factor TFIID subunit 7-like" ], [ "Q9BZL4-1", "protein_xref_pharos", "Q9BZL4", "Protein phosphatase 1 regulatory subunit 12C" ], [ "Q9NVL1-1", "protein_xref_pharos", "Q9NVL1", "Protein FAM86C1" ], [ "Q5QJ38-1", "protein_xref_pharos", "Q5QJ38", "Trichohyalin-like protein 1" ], [ "Q9NQ75-1", "protein_xref_pharos", "Q9NQ75", "Cas scaffolding protein family member 4" ], [ "P20930-1", "protein_xref_pharos", "P20930", "Filaggrin" ], [ "P20933-1", "protein_xref_pharos", "P20933", "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase" ], [ "P20936-1", "protein_xref_pharos", "P20936", "Ras GTPase-activating protein 1" ], [ "Q8NFX7-1", "protein_xref_pharos", "Q8NFX7", "Syntaxin-binding protein 6" ], [ "Q9UM21-1", "protein_xref_pharos", "Q9UM21", "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A" ], [ "Q496A3-1", "protein_xref_pharos", "Q496A3", "Spermatogenesis-associated serine-rich protein 1" ], [ "P83859-1", "protein_xref_pharos", "P83859", "Orexigenic neuropeptide QRFP" ], [ "P40617-1", "protein_xref_pharos", "P40617", "ADP-ribosylation factor-like protein 4A" ], [ "Q70EL4-1", "protein_xref_pharos", "Q70EL4", "Ubiquitin carboxyl-terminal hydrolase 43" ], [ "Q8TBF2-1", "protein_xref_pharos", "Q8TBF2", "Prostamide/prostaglandin F synthase" ], [ "Q15573-1", "protein_xref_pharos", "Q15573", "TATA box-binding protein-associated factor RNA polymerase I subunit A" ], [ "Q15572-1", "protein_xref_pharos", "Q15572", "TATA box-binding protein-associated factor RNA polymerase I subunit C" ], [ "Q9BQP9-1", "protein_xref_pharos", "Q9BQP9", "BPI fold-containing family A member 3" ], [ "Q9H999-1", "protein_xref_pharos", "Q9H999", "Pantothenate kinase 3" ], [ "P23919-1", "protein_xref_pharos", "P23919", "Thymidylate kinase" ], [ "Q8NHX4-1", "protein_xref_pharos", "Q8NHX4", "Spermatogenesis-associated protein 3" ], [ "Q8NHX9-1", "protein_xref_pharos", "Q8NHX9", "Two pore calcium channel protein 2" ], [ "A8MU46-1", "protein_xref_pharos", "A8MU46", "Smoothelin-like protein 1" ], [ "Q6ZNW5-1", "protein_xref_pharos", "Q6ZNW5", "GDP-D-glucose phosphorylase 1" ], [ "Q9NXR8-1", "protein_xref_pharos", "Q9NXR8", "Inhibitor of growth protein 3" ], [ "Q9C0H2-1", "protein_xref_pharos", "Q9C0H2", "Protein tweety homolog 3" ], [ "Q9C0H5-1", "protein_xref_pharos", "Q9C0H5", "Rho GTPase-activating protein 39" ], [ "Q4VXU2-1", "protein_xref_pharos", "Q4VXU2", "Polyadenylate-binding protein 1-like" ], [ "Q9C0H6-1", "protein_xref_pharos", "Q9C0H6", "Kelch-like protein 4" ], [ "Q9C0H9-5", "protein_xref_pharos", "Q9C0H9", "SRC kinase signaling inhibitor 1" ], [ "Q9NXR1-2", "protein_xref_pharos", "Q9NXR1", "Nuclear distribution protein nudE homolog 1" ], [ "Q00537-1", "protein_xref_pharos", "Q00537", "Cyclin-dependent kinase 17" ], [ "Q00536-1", "protein_xref_pharos", "Q00536", "Cyclin-dependent kinase 16" ], [ "Q9NXR5-1", "protein_xref_pharos", "Q9NXR5", "Ankyrin repeat domain-containing protein 10" ], [ "Q00532-1", "protein_xref_pharos", "Q00532", "Cyclin-dependent kinase-like 1" ], [ "Q96J66-1", "protein_xref_pharos", "Q96J66", "ATP-binding cassette sub-family C member 11" ], [ "O00244-1", "protein_xref_pharos", "O00244", "Copper transport protein ATOX1" ], [ "Q9UBM8-1", "protein_xref_pharos", "Q9UBM8", "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C" ], [ "Q9H2V7-1", "protein_xref_pharos", "Q9H2V7", "Protein spinster homolog 1" ], [ "O00241-1", "protein_xref_pharos", "O00241", "Signal-regulatory protein beta-1" ], [ "O00716-1", "protein_xref_pharos", "O00716", "Transcription factor E2F3" ], [ "Q8IX01-1", "protein_xref_pharos", "Q8IX01", "SURP and G-patch domain-containing protein 2" ], [ "Q3LI54-1", "protein_xref_pharos", "Q3LI54", "Keratin-associated protein 19-8" ], [ "Q9UBM1-1", "protein_xref_pharos", "Q9UBM1", "Phosphatidylethanolamine N-methyltransferase" ], [ "A8MTA8-1", "protein_xref_pharos", "A8MTA8", "Protein FAM166B" ], [ "Q9UBM4-1", "protein_xref_pharos", "Q9UBM4", "Opticin" ], [ "P24522-1", "protein_xref_pharos", "P24522", "Growth arrest and DNA damage-inducible protein GADD45 alpha" ], [ "Q13835-1", "protein_xref_pharos", "Q13835", "Plakophilin-1" ], [ "Q7Z3T1-1", "protein_xref_pharos", "Q7Z3T1", "Olfactory receptor 2W3" ], [ "A0AVF1-1", "protein_xref_pharos", "A0AVF1", "Intraflagellar transport protein 56" ], [ "P40424-1", "protein_xref_pharos", "P40424", "Pre-B-cell leukemia transcription factor 1" ], [ "P40425-1", "protein_xref_pharos", "P40425", "Pre-B-cell leukemia transcription factor 2" ], [ "P40426-1", "protein_xref_pharos", "P40426", "Pre-B-cell leukemia transcription factor 3" ], [ "Q8IZK6-1", "protein_xref_pharos", "Q8IZK6", "Mucolipin-2" ], [ "P40429-1", "protein_xref_pharos", "P40429", "60S ribosomal protein L13a" ], [ "P51991-1", "protein_xref_pharos", "P51991", "Heterogeneous nuclear ribonucleoprotein A3" ], [ "Q13838-1", "protein_xref_pharos", "Q13838", "Spliceosome RNA helicase DDX39B" ], [ "O00337-1", "protein_xref_pharos", "O00337", "Sodium/nucleoside cotransporter 1" ], [ "Q8TDW7-3", "protein_xref_pharos", "Q8TDW7", "Protocadherin Fat 3" ], [ "Q5M775-1", "protein_xref_pharos", "Q5M775", "Cytospin-B" ], [ "Q8WTV0-1", "protein_xref_pharos", "Q8WTV0", "Scavenger receptor class B member 1" ], [ "Q9H2I8-1", "protein_xref_pharos", "Q9H2I8", "Leucine-rich melanocyte differentiation-associated protein" ], [ "A0A075B6S2-1", "protein_xref_pharos", "A0A075B6S2", "Immunoglobulin kappa variable 2D-29" ], [ "P08842-1", "protein_xref_pharos", "P08842", "Steryl-sulfatase" ], [ "P03891-1", "protein_xref_pharos", "P03891", "NADH-ubiquinone oxidoreductase chain 2" ], [ "Q5VUR7-1", "protein_xref_pharos", "Q5VUR7", "Ankyrin repeat domain-containing protein 20A3" ], [ "P48960-1", "protein_xref_pharos", "P48960", "CD97 antigen" ], [ "P03897-1", "protein_xref_pharos", "P03897", "NADH-ubiquinone oxidoreductase chain 3" ], [ "P02768-1", "protein_xref_pharos", "P02768", "Serum albumin" ], [ "P20645-1", "protein_xref_pharos", "P20645", "Cation-dependent mannose-6-phosphate receptor" ], [ "P05386-1", "protein_xref_pharos", "P05386", "60S acidic ribosomal protein P1" ], [ "P05387-1", "protein_xref_pharos", "P05387", "60S acidic ribosomal protein P2" ], [ "P24863-1", "protein_xref_pharos", "P24863", "Cyclin-C" ], [ "P08559-1", "protein_xref_pharos", "P08559", "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial" ], [ "P02760-1", "protein_xref_pharos", "P02760", "Protein AMBP" ], [ "P02763-1", "protein_xref_pharos", "P02763", "Alpha-1-acid glycoprotein 1" ] ] }, "readme": "Name\n - Human UniProtKB Xref Pharos\n\nVersion\n - 1.5.36\n\nCreated on\n - 2020-03-20T14:14:17.733990\n\nModified on\n - 2020-04-03T23:11:14.573454\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu]\n\nAuthors\n - Tudor I Oprea [TOprea@salud.unm.edu], Paul Barrett [paul.barrett@nih.gov], Ajay Pillai [ajay.pillai3@nih.gov]\n\nChecksum\n - \n\nUsability Domain\n - The Human UniProtKB Xref Pharos dataset contains human [taxid:9606] UniProtKB canonical accessions cross-referenced to Pharos UniProtKB accessions. The data is from Pharos API based on TCRD version 5.4.0. If you use this dataset please provide proper attribution to Pharos and GlyGen\n - Pharos is the user interface to the Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) program funded by the National Institutes.\n - The goal of KMC is to develop a comprehensive, integrated knowledge-base for the Druggable Genome (DG) to illuminate the uncharacterized and/or poorly annotated portion of the DG, focusing on three of the most commonly drug-targeted protein families: G-protein-coupled receptors (GPCRs), ion channels (ICs) and kinases\n - Nguyen, D.-T., Mathias, S. et al, Pharos: Collating Protein Information to Shed Light on the Druggable Genome , Nucl. Acids Res.i>, 2017, 45(D1), D995-D1002. DOI: 10.1093/nar/gkw1072\n - https://pharos.nih.gov/about\n\nDescription Domain\n Keywords\n - Pharos\n - Illuminating the Druggable Genome\n - drug-targeted protein families\n - G-protein-coupled receptors (GPCRs)\n - ion channels (ICs)\n - kinases\n\n Pipeline Steps\n - Step-1: The script extracts the UniProtKB accessions and protein name from the Pharos API and maps to the GlyGen's UniProtKB canonical accessions (masterlist) to generate a csv dataset. the accessions that are not mapped are logged in the log file. \n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: human_protein_masterlist.csv\n URI: https://data.glygen.org/ln2wwwdata/reviewed/human_protein_masterlist.csv\n Name: pharos_protein_all_9606.json\n URI: https://data.glygen.org/ln2wwwdata/source/pharos_protein_all_9606.json\n Output Subdomain\n Name: human_protein_xref_pharos.csv\n URI: http://data.glygen.org/ln2wwwdata/reviewed/human_protein_xref_hgnc.csv\n Name: glygen_pharos_xref_mapping.log\n URI: http://data.glygen.org/ln2wwwdata/logs/glygen_pharos_xref_mapping.log\n Name: human_protein_xref_pharos.stat.csv\n URI: http://data.glygen.org/ln2wwwdata/reviewed/human_protein_xref_pharos.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"Accession assigned to the protein isoform chosen to be the canonical sequence to which all positional annotation refers in UniProtKB database\"\n Unique Values: \"20029\"\n Name: \"xref_label\"\n Description: \"\"\n Unique Values: \"20026\"\n Name: \"xref_id\"\n Description: \"\"\n Unique Values: \"20029\"\n Name: \"xref_key\"\n Description: \"\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.5.36/reviewed/human_protein_xref_pharos.csv" }