{ "uniprot_canonical_ac": "A5PL33-1", "synonyms_protein_refseq": [ "protein KRBA1 isoform 2", "protein KRBA1" ], "sequence": { "header": "sp|A5PL33-1|KRBA1_HUMAN Isoform 1 of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=3 CANONICAL=A5PL33-1", "length": 1030, "sequence": "MRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGLRAEACESARLGQGRGEAPTRSLHLVSPQVFTSSCVPACHQRGFKDPGATRPGVWRWLPEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPELPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALAGLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGPTRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSSTPSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIPERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH" }, "uniprot_id": "KRBA1_HUMAN", "synonyms_gene_uniprotkb": [ "KRBA1", "KIAA1862" ], "enzyme_annotation": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5PL33", "id": "A5PL33", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Protein KRBA1", "short": "" }, "publication": [ { "title": "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9653119", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG", "date": "1998", "pmid": "9653119" }, { "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12477932", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277116.1", "id": "NP_001277116.1", "database": "RefSeq" } ], "authors": "Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA", "date": "2002", "pmid": "12477932" }, { "title": "A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16606702", "journal": "Genome research", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Huntley S, Baggott DM, Hamilton AT, Tran-Gyamfi M, Yang S, Kim J, Gordon L, Branscomb E, Stubbs L", "date": "2006", "pmid": "16606702" }, { "title": "A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9637681", "journal": "Genes & development", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Rachez C, Suldan Z, Ward J, Chang CP, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP", "date": "1998", "pmid": "9637681" }, { "title": "Transcriptional regulatory elements in the human genome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16719718", "journal": "Annual review of genomics and human genetics", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Maston GA, Evans SK, Green MR", "date": "2006", "pmid": "16719718" }, { "title": "Transcriptional coactivator complexes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11395415", "journal": "Annual review of biochemistry", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Naar AM, Lemon BD, Tjian R", "date": "2001", "pmid": "11395415" }, { "title": "A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15175151", "journal": "Molecular cell", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD", "date": "2004", "pmid": "15175151" }, { "title": "A novel mediator between activator proteins and the RNA polymerase II transcription apparatus.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/2163759", "journal": "Cell", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Kelleher RJ 3rd, Flanagan PM, Kornberg RD", "date": "1990", "pmid": "2163759" }, { "title": "KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10330177", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Ryan RF, Schultz DC, Ayyanathan K, Singh PB, Friedman JR, Fredericks WJ, Rauscher FJ 3rd", "date": "1999", "pmid": "10330177" }, { "title": "KAP-1, a novel corepressor for the highly conserved KRAB repression domain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8769649", "journal": "Genes & development", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, Neilson EG, Rauscher FJ 3rd", "date": "1996", "pmid": "8769649" }, { "title": "Kruppel-associated boxes are potent transcriptional repression domains.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8183939", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Margolin JF, Friedman JR, Meyer WK, Vissing H, Thiesen HJ, Rauscher FJ 3rd", "date": "1994", "pmid": "8183939" }, { "title": "KRAB-containing zinc-finger repressor proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14519192", "journal": "Genome biology", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Urrutia R", "date": "2003", "pmid": "14519192" }, { "title": "Dynamic regulation of pol II transcription by the mammalian Mediator complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15896744", "journal": "Trends in biochemical sciences", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Malik S, Roeder RG", "date": "2005", "pmid": "15896744" }, { "title": "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10235266", "journal": "Nature", "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" } ], "authors": "Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP", "date": "1999", "pmid": "10235266" } ], "uniprot_ac": "A5PL33", "synonyms_gene_refseq": [ "KRBA1" ], "mutation": [], "synonyms_protein_uniprotkb": [ "Protein KRBA1" ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5PL33#C9JYG0-1", "isoform_ac": "C9JYG0-1", "locus": { "end_pos": 149719639, "start_pos": 149720123, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000486744", "id": "ENST00000486744", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000419900", "id": "ENSP00000419900", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|C9JYG0-1|KRBA1_HUMAN Computationally mapped isoform of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=2 CANONICAL=A5PL33-1", "length": 35, "sequence": "MRENYETLVSVEPGRAVGGGSHADEGQEPAGCGDP" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#A5PL33-1", "isoform_ac": "A5PL33-1", "locus": { "end_pos": 149719639, "start_pos": 149734044, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000319551", "id": "ENST00000319551", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000317165", "id": "ENSP00000317165", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5PL33-1|KRBA1_HUMAN Isoform 1 of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=3 CANONICAL=A5PL33-1", "length": 1030, "sequence": "MRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGLRAEACESARLGQGRGEAPTRSLHLVSPQVFTSSCVPACHQRGFKDPGATRPGVWRWLPEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPELPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALAGLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGPTRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSSTPSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIPERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#A0A0C4DH65-1", "isoform_ac": "A0A0C4DH65-1", "locus": { "end_pos": 149715055, "start_pos": 149734044, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000496259", "id": "ENST00000496259", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000418647", "id": "ENSP00000418647", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0C4DH65-1|KRBA1_HUMAN Computationally mapped isoform of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=1 CANONICAL=A5PL33-1", "length": 1064, "sequence": "MARQVSITFKDLAVRFSEEEWRLLEEGQREFYRDVMRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGLRAEACESARLGQGRGEAPTRSLHLVSPQVFTSSCVPACHQRGFKDPGATRPGVWRWLPEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPELPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALAGLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGPTRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSSTPSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIPERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#A5PL33-3", "isoform_ac": "A5PL33-3", "locus": { "end_pos": 149719639, "start_pos": 149734044, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000485033", "id": "ENST00000485033", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000420112", "id": "ENSP00000420112", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5PL33-3|KRBA1_HUMAN Isoform 3 of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=3 CANONICAL=A5PL33-1", "length": 969, "sequence": "MRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPELPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALAGLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGPTRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSSTPSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIPERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#C9J5U6-1", "isoform_ac": "C9J5U6-1", "locus": { "end_pos": 149719639, "start_pos": 149720989, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000497895", "id": "ENST00000497895", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000417921", "id": "ENSP00000417921", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|C9J5U6-1|KRBA1_HUMAN Computationally mapped isoform of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=1 CANONICAL=A5PL33-1", "length": 103, "sequence": "MRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPE" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#A5PL33-2", "isoform_ac": "A5PL33-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A5PL33-2|KRBA1_HUMAN Isoform 2 of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=3 CANONICAL=A5PL33-1", "length": 1029, "sequence": "MRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGLRAEACESARLGQGRGEAPTRSLHLVSPQVFTSSCVPACHQRGFKDPGATRPGVWRWLPEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPELPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALAGLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGPTRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSSTPSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIPERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#A0A087WVC5-1", "isoform_ac": "A0A087WVC5-1", "locus": { "end_pos": 149720101, "start_pos": 149730586, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000621069", "id": "ENST00000621069", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000479341", "id": "ENSP00000479341", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WVC5-1|KRBA1_HUMAN Computationally mapped isoform of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=1 CANONICAL=A5PL33-1", "length": 617, "sequence": "XPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGEPGVS" } }, { "url": "https://www.uniprot.org/uniprot/A5PL33#H7C530-1", "isoform_ac": "H7C530-1", "locus": { "end_pos": 149720950, "start_pos": 149721842, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000467333", "id": "ENST00000467333", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000418841", "id": "ENSP00000418841", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H7C530-1|KRBA1_HUMAN Computationally mapped isoform of Protein KRBA1 OS=Homo sapiens OX=9606 GN=KRBA1 PE=1 SV=1 CANONICAL=A5PL33-1", "length": 167, "sequence": "XRGASLDGERASPEAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPISESDTAGTGRTSISKALIVASEDLDPVPSSFFSRTQFPCCAVLLLTKYAREQDNIFSLWCNHQRGGMMLSPWGACHPAPITEHFVHRKSPAVSNMQAHGQQH" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "resource": "Reactome", "id": "R-HSA-212436", "name": "Generic Transcription Pathway" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:84626", "resource": "KEGG Pathway", "id": "hsa:84626", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q6NXZ1-1", "protein_name": "Protein KRBA1", "sequence": { "length": 1043, "sequence": "MRENYETLVSVGTSELLPLSAFLSPAEAGGATSGESHQDKGQKPHLEHSSQGEQPQQSLHLTALVQLVKEIPEFLFGEVKGTEDYSESGSTSLDGEQTSPEVAVVVEACPPRGLLNSLPESPASHPSLATTPTGSSTSGGPPGDWAHGSPLPAIGTDDKPLSIEKEGVGASRETSIHSTQSLGQSKSYLRQERGSMGTGTLPENSPLQGLINCLKEILVPRPQHRGTAPDLPPSLPGLSVLKQTRAEVEAGSLPCPVKTEAASGDCPLQGLLNCLKEIPKAPDRRPSPSGASDLQLQEDPGKRHSGGMRHLQTPPHPSHEAGSMLATVKVEDGWAQSPPVPASCQLSRQGYSSYSTGDNREVRVPRWGPMTLASRASSSPLEALEACLKGIPPGGSSPLQSLAISWSRSPQLGDAGSQRFELQQQGSHSEEATREPLLPLSLQGYMREGPGVQPCGSQGTPTSFSSASSSDGDLDFRSPRSSQGQRLGKGYLPGNSPLQGLENCLREIPIPRPQAAWPCSSAVNRGLKRTEPRNWTGDREGLRGEASEPPHLRQRPGEVPSRSLHQDSPQTCTSTCHQVTTRPGTWQWPQEETATMPSPLHRLENSLRGILPVRPLRFTCVTGPGPSPSPCSSSSFSSSDGEDLRPEPAFWQSPLQQKDQPPSCKDPVRLCPVSGASPRVNSNSCSAEDRERTEPRDCSSLSAGRAEEKPHPPRREDGAERTRQPGPVTNAEGKGAAAGHPSPAPQLEEKPEPKGTEDSRDLEPGHRPPSAAARTQGKLLSGDPPESPSKSPLPTTVLSKWSPTSLQPPCPCGRSLQQELHNLGTALTDKLDRLAAALAGLTQEVATMKTQMDQLRRHPRSLGPKGQGSWQLALPQRPRWVNRLGHRHLPYWRQKGPTRPRPKILRTQAEGCKTSDRPGLSRGKGSLVPQLPPEASLVESSRPTCSSSQQISSTPGGHTVLTAHPPLEHTACHQNPLSPSVPTSVQVPLVASPATSADTEPPAARVAAISIPNQPKEPDSLLGEALSRDLWGGDHRDPRWGAH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/15880", "id": "15880", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "synthesized_glycans": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277116.1", "ac": "NP_001277116.1", "name": "protein KRBA1 isoform 2", "summary": "" }, "go_annotation": {}, "site_annotation": [ { "end_pos": 538, "annotation": "n_glycosylation_sequon", "start_pos": 536 }, { "end_pos": 399, "annotation": "n_glycosylation_sequon", "start_pos": 397 } ], "crossref": [ { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5PL33", "id": "PR_A5PL33", "database": "PRO" }, { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PL33", "id": "A5PL33", "database": "BioMuta" }, { "url": "https://pharos.nih.gov/targets/A5PL33", "id": "A5PL33", "database": "PHAROS" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212436", "id": "R-HSA-212436", "database": "Reactome" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22740", "id": "PTHR22740", "database": "PANTHER" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A5PL33*", "id": "A5PL33", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277116.1", "id": "NP_001277116.1", "database": "RefSeq" }, { "url": "http://pfam.xfam.org/family/PF15287", "id": "PF15287", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040095", "id": "IPR040095", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029317", "id": "IPR029317", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:84626", "id": "hsa:84626", "database": "KEGG Pathway" }, { "url": "http://www.orthodb.org/?query=248191at2759", "id": "248191at2759", "database": "OrthoDB" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=KRBA1", "id": "KRBA1", "database": "GeneCards" }, { "url": "https://www.nextprot.org/entry/NX_A5PL33", "id": "NX_A5PL33", "database": "neXtProt" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/84626", "id": "84626", "database": "GeneID" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=22228", "id": "22228", "database": "HGNC" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ], "expression_disease": [ { "name": "Urinary bladder cancer [DO disease name]", "trend": "Down", "icd10": "C67", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:11054", "significant": "No" }, { "name": "Prostate cancer [DO disease name]", "trend": "Down", "icd10": "C61", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "Prostate cancer" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:10283", "significant": "Yes" }, { "name": "Thyroid gland cancer [DO disease name]", "trend": "Up", "icd10": "C73", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid gland cancer" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:1781", "significant": "Yes" }, { "name": "Liver cancer [DO disease name]", "trend": "Up", "icd10": "C22.0", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "Liver cancer" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:3571", "significant": "No" }, { "name": "Esophageal cancer [DO disease name]", "trend": "Down", "icd10": "C15.3", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "Esophageal cancer" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:5041", "significant": "Yes" }, { "name": "Lung adenocarcinoma [DO disease name]", "trend": "Down", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "Lung adenocarcinoma" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:3910", "significant": "No" }, { "name": "Lung squamous cell carcinoma [DO disease name]", "trend": "Up", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "Lung squamous cell carcinoma" }, "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PL33", "id": "A5PL33", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:3907", "significant": "Yes" } ], "glycosylation": [], "disease": [], "mass": { "monoisotopic_mass": 107498.0, "chemical_mass": 107498.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000133619", "id": "ENSG00000133619", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A5PL33", "": "", "name": "KIAA1862; KRBA1", "locus": { "end_pos": 149734575, "start_pos": 149714781, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000133619", "id": "ENSG00000133619", "database": "Ensembl Gene" } ] } } ] }