{ "uniprot_canonical_ac": "A2ARP9-1", "synonyms_protein_refseq": [], "sequence": { "header": "sp|A2ARP9-1|CTSR2_MOUSE Isoform 1 of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=2 CANONICAL=A2ARP9-1", "length": 588, "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK" }, "uniprot_id": "CTSR2_MOUSE", "synonyms_gene_uniprotkb": [ "Catsper2" ], "enzyme_annotation": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Cation channel sperm-associated protein 2; CatSper2", "short": "" }, "publication": [ { "title": "Identical phenotypes of CatSper1 and CatSper2 null sperm.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16036917", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Westenbroek R.E., Quill T.A., Hille B., Babcock D.F., Carlson A.E., Schuh S.M.", "date": "2005", "pmid": "16036917" }, { "title": "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21224844", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Clapham D.E., Krapivinsky G., Krapivinsky L., Chung J.J., Navarro B.", "date": "2011", "pmid": "21224844" }, { "title": "Progesterone activates the principal Ca2+ channel of human sperm.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21412339", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Kirichok Y., Lishko P.V., Botchkina I.L.", "date": "2011", "pmid": "21412339" }, { "title": "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17347248", "journal": "Mol. Hum. Reprod.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Ding X.-F., Kong X.-B., Li H.-G., Liao A.-H., Xiong C.-L.", "date": "2007", "pmid": "17347248" }, { "title": "Hyperactivated sperm motility driven by CatSper2 is required for fertilization.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14657366", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Garbers D.L., Quill T.A., Doolittle L.K., Hammer R.E., Rossi K.L., Sugden S.A.", "date": "2003", "pmid": "14657366" }, { "title": "Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17174296", "journal": "Dev. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Marquez B., Suarez S.S., Ignotz G.", "date": "2007", "pmid": "17174296" }, { "title": "A voltage-gated ion channel expressed specifically in spermatozoa.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11675491", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "authors": "Garbers D.L., Clapham D.E., Ren D., Quill T.A.", "date": "2001", "pmid": "11675491" } ], "uniprot_ac": "A2ARP9", "synonyms_gene_refseq": [], "mutation": [], "synonyms_protein_uniprotkb": [ "Cation channel sperm-associated protein 2", "CatSper2" ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9#D6RCY8-1", "isoform_ac": "D6RCY8-1", "locus": { "end_pos": 121399450, "start_pos": 121412288, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000154604", "id": "ENSMUST00000154604", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119091", "id": "ENSMUSP00000119091", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RCY8-1|CTSR2_MOUSE Computationally mapped isoform of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=1 CANONICAL=A2ARP9-1", "length": 134, "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIGDSTLNH" } }, { "url": "https://www.uniprot.org/uniprot/A2ARP9#A2ARP9-1", "isoform_ac": "A2ARP9-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2ARP9-1|CTSR2_MOUSE Isoform 1 of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=2 CANONICAL=A2ARP9-1", "length": 588, "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK" } }, { "url": "https://www.uniprot.org/uniprot/A2ARP9#A0A0A0MQ85-1", "isoform_ac": "A0A0A0MQ85-1", "locus": { "end_pos": 121394459, "start_pos": 121412288, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000038073", "id": "ENSMUST00000038073", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000037222", "id": "ENSMUSP00000037222", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MQ85-1|CTSR2_MOUSE Computationally mapped isoform of Cation channel sperm-associated protein 2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=1 CANONICAL=A2ARP9-1", "length": 588, "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDKSDATESDGEKNENEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1300642", "resource": "Reactome", "id": "R-MMU-1300642", "name": "Sperm Motility And Taxes" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9#function", "annotation": "Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9#function", "id": "A2ARP9", "database": "UniProtKB" } ] } ], "orthologs": [], "synthesized_glycans": [], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "calcium channel activity", "id": "GO:0005262" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "calcium activated cation channel activity", "id": "GO:0005227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005244", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "voltage-gated ion channel activity", "id": "GO:0005244" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "CatSper complex", "id": "GO:0036128" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "sperm flagellum", "id": "GO:0036126" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "sperm flagellum", "id": "GO:0036126" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "fertilization", "id": "GO:0009566" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "flagellated sperm motility", "id": "GO:0030317" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "flagellated sperm motility", "id": "GO:0030317" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "flagellated sperm motility", "id": "GO:0030317" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "sperm capacitation", "id": "GO:0048240" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034765", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "id": "A2ARP9", "database": "UniProtKB" } ], "name": "regulation of ion transmembrane transport", "id": "GO:0034765" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "http://www.informatics.jax.org/marker/MGI:2387404", "id": "2387404", "database": "MGI" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028747", "id": "IPR028747", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ARP9*", "id": "A2ARP9", "database": "IntAct" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1300642", "id": "R-MMU-1300642", "database": "Reactome" }, { "url": "http://pfam.xfam.org/family/PF00520", "id": "PF00520", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46923", "id": "PTHR46923", "database": "PANTHER" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "id": "IPR027359", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "id": "IPR005821", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ARP9", "id": "PR_A2ARP9", "database": "PRO" } ], "expression_disease": [], "glycosylation": [], "disease": [], "mass": { "monoisotopic_mass": 68572.0, "chemical_mass": 68572.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ARP9", "": "", "name": "Catsper2", "locus": { "end_pos": 121392631, "start_pos": 121413792, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000033486", "id": "ENSMUSG00000033486", "database": "Ensembl Gene" } ] } } ] }