{ "uniprot_canonical_ac": "A2AFR3-1", "synonyms_protein_refseq": [ "FERM and PDZ domain-containing protein 4 isoform a", "FERM and PDZ domain-containing protein 4; PDZ domain-containing protein 10; PSD-95-interacting regulator of spine morphogenesis" ], "sequence": { "header": "sp|A2AFR3-1|FRPD4_MOUSE Isoform 1 of FERM and PDZ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Frmpd4 PE=1 SV=1 CANONICAL=A2AFR3-1", "length": 1320, "sequence": "MDVFSFVKIPKLSSHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTV" }, "uniprot_id": "FRPD4_MOUSE", "synonyms_gene_uniprotkb": [ "Frmpd4", "Gm196", "Kiaa0316", "Pdzd10", "Pdzk10" ], "enzyme_annotation": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "FERM and PDZ domain-containing protein 4; PSD-95-interacting regulator of spine morphogenesis; Preso; PDZ domain-containing protein 10", "short": "" }, "publication": [ { "title": "Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22074847", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ], "authors": "Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, Sumimoto H", "date": "2011", "pmid": "22074847" }, { "title": "Preso1 dynamically regulates group I metabotropic glutamate receptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22561452", "journal": "Nature neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ], "authors": "Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF", "date": "2012", "pmid": "22561452" }, { "title": "The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30523785", "journal": "Developmental cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ], "authors": "Lavado A, Park JY, Pare J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X", "date": "2018", "pmid": "30523785" }, { "title": "FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29267967", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ], "authors": "Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley PF", "date": "2018", "pmid": "29267967" }, { "title": "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19118189", "journal": "J. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ], "authors": "Choi J., Kim K., Yang J., Lee H.W., Kim E., Kim H., Choi S.Y., Eom S.H., Kang G.B., Na M., Shin H.", "date": "2008", "pmid": "19118189" } ], "uniprot_ac": "A2AFR3", "synonyms_gene_refseq": [ "Frmpd4", "Gm196; Pdzd10; Pdzk10; PKAP1; preso; Preso1" ], "mutation": [], "synonyms_protein_uniprotkb": [ "FERM and PDZ domain-containing protein 4", "PSD-95-interacting regulator of spine morphogenesis", "Preso", "PDZ domain-containing protein 10" ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3#A2AFR3-2", "isoform_ac": "A2AFR3-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2AFR3-2|FRPD4_MOUSE Isoform 2 of FERM and PDZ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Frmpd4 PE=1 SV=1 CANONICAL=A2AFR3-1", "length": 1280, "sequence": "MMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTV" } }, { "url": "https://www.uniprot.org/uniprot/A2AFR3#A2AFR3-3", "isoform_ac": "A2AFR3-3", "locus": { "end_pos": 167475301, "start_pos": 167897558, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112145", "id": "ENSMUST00000112145", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107773", "id": "ENSMUSP00000107773", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AFR3-3|FRPD4_MOUSE Isoform 3 of FERM and PDZ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Frmpd4 PE=1 SV=1 CANONICAL=A2AFR3-1", "length": 1312, "sequence": "MRSHSCHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTV" } }, { "url": "https://www.uniprot.org/uniprot/A2AFR3#A2AFR3-1", "isoform_ac": "A2AFR3-1", "locus": { "end_pos": 167475301, "start_pos": 168122826, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112149", "id": "ENSMUST00000112149", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107777", "id": "ENSMUSP00000107777", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AFR3-1|FRPD4_MOUSE Isoform 1 of FERM and PDZ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Frmpd4 PE=1 SV=1 CANONICAL=A2AFR3-1", "length": 1320, "sequence": "MDVFSFVKIPKLSSHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTV" } }, { "url": "https://www.uniprot.org/uniprot/A2AFR3#A0A571BG68-1", "isoform_ac": "A0A571BG68-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "tr|A0A571BG68-1|FRPD4_MOUSE Computationally mapped isoform of FERM and PDZ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Frmpd4 PE=1 SV=1 CANONICAL=A2AFR3-1", "length": 1778, "sequence": "MEEDLEGENWSTFSIPWGFGKAAEDNREHVCRHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTALTEPGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGIQAFGEAVSWWPADLRGGSPRTPPSQRALRHSSRILSGPVGLETFQERTKGVVSLKYPGITEAQEVSSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPMSHKDSKVYRTLPLRKLESSNWRCRGPFSYCFLNQGQDEDGDEDEEEGEATLQVSCLYRPQITQAMSEPGNSSLVVGLQKQGEELSRGTALKVWTEDPDGPDDLDFSSLAFDARIARINALKANTYGMPDGFLEAQNDANELLCLVRATKARKEESRPETYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPEEMLLAMSSSFQVLCCLTEACMRLVKVVNTETQRQEIVAKIDEVVINYICLLKAAEAATGKTTGDPNIGLSMRHSTTMAALVSTLTRSLKMLLNK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:333605", "resource": "KEGG Pathway", "id": "mmu:333605", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "annotation": "The findings point to an important role of FRMPD4 in normal cognitive development and function in humans and mice, and support the hypothesis that FRMPD4 mutations cause ID by disrupting dendritic spine morphogenesis in glutamatergic neurons.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AFR3#function", "annotation": "Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3#function", "id": "A2AFR3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4A3K7-1", "protein_name": "Similar to KIAA0316 protein (Predicted); FERM and PDZ domain-containing 4", "sequence": { "length": 1705, "sequence": "MTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILFTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGTENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKAVEMTDSTLCPKEHRHLYIDNTYSSDELSQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTLGYERMLDENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVSEINQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHENKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPTVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKTPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLAEGEGKCPLSGNVPGKKQQGTKIAETEEDTKGKVGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGVEAPAMKAFPRGPGLGNREAEGKEDGTMEGEADDASGLGQGERFLSDMACVASAKDLDNPEDTDSPTCDHATKLPEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHLIPDASGKGGSYISPEERVAGHPNHGATFKELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTALTEPGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGNQAFGEAVSWRPADLRGGSLRTPPSQRALRHSSSILSGPVGLETFQEGTKGVVSLKYPGITEAQEASSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPMSHKDSKVYRTLPLRKLESSNWRCRGPFSYCFLNQGQDEDGDEDEEGEATLQVSCLYRPHITQGMPETSNSSLAVGLQKQGEELSRGTVLKDWTEDPDGPDDLDFSSLAFDARIARINALKANTYGMPDGFLEAQNDANELLCLVRATKAKREESRPEAYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPEEMLLAMSSSFQVLCCLTEACMRLVKVVNSETQRQEIVEKIDEVVINYICLLKAAEAATGKTTGDPSIGLSMRHSTTMAALVSTLTRSLKMLLNK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/45843", "id": "45843", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q14CM0-1", "protein_name": "FERM and PDZ domain-containing protein 4; PSD-95-interacting regulator of spine morphogenesis; Preso; PDZ domain-containing protein 10", "sequence": { "length": 1322, "sequence": "MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/45843", "id": "45843", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "synthesized_glycans": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "ac": "NP_001028502.1", "name": "FERM and PDZ domain-containing protein 4 isoform a", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "glutamatergic synapse", "id": "GO:0098978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "postsynaptic density", "id": "GO:0014069" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "dendritic spine", "id": "GO:0043197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "postsynaptic actin cytoskeleton organization", "id": "GO:0098974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051835", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "id": "A2AFR3", "database": "UniProtKB" } ], "name": "positive regulation of synapse structural plasticity", "id": "GO:0051835" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 912, "annotation": "n_glycosylation_sequon", "start_pos": 910 }, { "end_pos": 909, "annotation": "n_glycosylation_sequon", "start_pos": 907 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13183", "id": "cd13183", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "id": "IPR000299", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "id": "cd00201", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "id": "IPR019748", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "id": "IPR019749", "database": "InterPro" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000049176", "id": "ENSMUSG00000049176", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:3042378", "id": "3042378", "database": "MGI" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AFR3*", "id": "A2AFR3", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "id": "IPR035963", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00595", "id": "PF00595", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00373", "id": "PF00373", "database": "Pfam" }, { "url": "http://www.orthodb.org/?query=57420at2759", "id": "57420at2759", "database": "OrthoDB" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AFR3", "id": "PR_A2AFR3", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041779", "id": "IPR041779", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:333605", "id": "mmu:333605", "database": "KEGG Pathway" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "id": "cd14473", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "id": "IPR001478", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "id": "IPR036020", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/333605", "id": "333605", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "id": "IPR001202", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "id": "IPR014352", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "id": "IPR029071", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "id": "IPR036034", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028502.1", "id": "NP_001028502.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "disease": [], "mass": { "monoisotopic_mass": 144978.0, "chemical_mass": 144978.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AFR3", "": "", "name": "Gm196; Pdzd10; Kiaa0316; Frmpd4; Gm196; Pdzd10; Pdzk10; PKAP1; preso; Preso1; Pdzk10", "locus": { "end_pos": 167471309, "start_pos": 168577231, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000049176", "id": "ENSMUSG00000049176", "database": "Ensembl Gene" } ] } } ] }