{
    "uniprot_canonical_ac": "A5PLL7-1", 
    "synonyms_protein_refseq": [
        "transmembrane protein 189 isoform 2"
    ], 
    "sequence": {
        "header": "sp|A5PLL7-1|TM189_HUMAN Isoform 1 of Transmembrane protein 189  OS=Homo sapiens OX=9606 GN=TMEM189 PE=1 SV=3 CANONICAL=A5PLL7-1", 
        "length": 270, 
        "sequence": "MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
    }, 
    "uniprot_id": "TM189_HUMAN", 
    "synonyms_gene_uniprotkb": [
        "TMEM189", 
        "KUA"
    ], 
    "enzyme_annotation": [], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Transmembrane protein 189", 
        "short": ""
    }, 
    "publication": [
        {
            "title": "Molecular basis of T cell-mediated recognition of pancreatic cancer cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11280764", 
            "journal": "Cancer Res.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155977.1", 
                    "id": "NP_001155977.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ito M., Itoh K., Shichijo S., Harashima N., Ochi M., Saito N., Tsuda N.", 
            "date": "2001", 
            "pmid": "11280764"
        }, 
        {
            "title": "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11076860", 
            "journal": "Genome Res.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Carrio R., Merino J., Guigo R., Cormand B., Macaya A., Valeri M., Thomson T.M., Diaz V.M., Lozano J.J., Loukili N., Abril J., Burset M., Corominas M., Serras F.", 
            "date": "2000", 
            "pmid": "11076860"
        }, 
        {
            "title": "Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21048031", 
            "journal": "Haematologica", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155977.1", 
                    "id": "NP_001155977.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Casabonne D, Reina O, Benavente Y, Becker N, Maynadie M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S", 
            "date": "2011", 
            "pmid": "21048031"
        }
    ], 
    "uniprot_ac": "A5PLL7", 
    "synonyms_gene_refseq": [
        "TMEM189", 
        "KUA"
    ], 
    "mutation": [
        {
            "sequence_org": "A", 
            "subjects_tested": "50", 
            "subjects_positive": "1", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid gland cancer"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "sequence_mut": "V", 
            "start_pos": 2, 
            "end_pos": 2, 
            "type": "Point mutation", 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%)."
        }
    ], 
    "synonyms_protein_uniprotkb": [
        "Transmembrane protein 189"
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A5PLL7#A5PLL7-2", 
            "isoform_ac": "A5PLL7-2", 
            "locus": {
                "end_pos": 50125061, 
                "start_pos": 50153637, 
                "chromosome": "20", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000371650", 
                        "id": "ENST00000371650", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000360713", 
                        "id": "ENSP00000360713", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A5PLL7-2|TM189_HUMAN Isoform 2 of Transmembrane protein 189  OS=Homo sapiens OX=9606 GN=TMEM189 PE=1 SV=3 CANONICAL=A5PLL7-1", 
                "length": 267, 
                "sequence": "MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWGSVELPIAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5PLL7#A5PLL7-1", 
            "isoform_ac": "A5PLL7-1", 
            "locus": {
                "end_pos": 50125061, 
                "start_pos": 50153637, 
                "chromosome": "20", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000371652", 
                        "id": "ENST00000371652", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000360715", 
                        "id": "ENSP00000360715", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A5PLL7-1|TM189_HUMAN Isoform 1 of Transmembrane protein 189  OS=Homo sapiens OX=9606 GN=TMEM189 PE=1 SV=3 CANONICAL=A5PLL7-1", 
                "length": 270, 
                "sequence": "MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5PLL7#F8WBY2-1", 
            "isoform_ac": "F8WBY2-1", 
            "locus": {
                "end_pos": 50151302, 
                "start_pos": 50153637, 
                "chromosome": "20", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000453505", 
                        "id": "ENST00000453505", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000411045", 
                        "id": "ENSP00000411045", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F8WBY2-1|TM189_HUMAN Computationally mapped isoform of Transmembrane protein 189  OS=Homo sapiens OX=9606 GN=TMEM189 PE=1 SV=1 CANONICAL=A5PLL7-1", 
                "length": 45, 
                "sequence": "MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPVPFTL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5PLL7#F8W924-1", 
            "isoform_ac": "F8W924-1", 
            "locus": {
                "end_pos": 50129659, 
                "start_pos": 50153637, 
                "chromosome": "20", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000371658", 
                        "id": "ENST00000371658", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000360721", 
                        "id": "ENSP00000360721", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F8W924-1|TM189_HUMAN Computationally mapped isoform of Transmembrane protein 189  OS=Homo sapiens OX=9606 GN=TMEM189 PE=1 SV=1 CANONICAL=A5PLL7-1", 
                "length": 91, 
                "sequence": "MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVGFHPTLPGAPH"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5PLL7#Q5TGE2-1", 
            "isoform_ac": "Q5TGE2-1", 
            "locus": {
                "end_pos": 50125061, 
                "start_pos": 50131035, 
                "chromosome": "20", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000371656", 
                        "id": "ENST00000371656", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000360719", 
                        "id": "ENSP00000360719", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|Q5TGE2-1|TM189_HUMAN Computationally mapped isoform of Transmembrane protein 189  OS=Homo sapiens OX=9606 GN=TMEM189 PE=1 SV=1 CANONICAL=A5PLL7-1", 
                "length": 195, 
                "sequence": "MNERAIAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:387521", 
            "resource": "KEGG Pathway", 
            "id": "hsa:387521", 
            "name": ""
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:387522", 
            "resource": "KEGG Pathway", 
            "id": "hsa:387522", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155977.1", 
            "annotation": "Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155977.1", 
                    "id": "NP_001155977.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2JUA8-1", 
            "protein_name": "Transmembrane protein 189", 
            "sequence": {
                "length": 258, 
                "sequence": "NGCLAQSSAAVEAPAACASRSPPLPLPTGKRLQEWCSVILCFSLIAHNSVHLLLLARWEHTPLVILGVVAGALVADFLSGLVHWGADTWGSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFQTQSPETLEQLYPWECFVFCLIIFGTFTNQIHKWSHTYLGLPCWVTVLQDWHVILPRKHHRIHHVAPHETYFCITTGWLNYPLEVIGFWRRLEDVIQSLTGEKPRADDMKWAQKIK"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A5PLL7/", 
                    "id": "A5PLL7", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q99LQ7-1", 
            "protein_name": "Transmembrane protein 189", 
            "sequence": {
                "length": 271, 
                "sequence": "MAGAEDAPGRQPELDEDETAEGRRWGAQHAGARELAALYSPGKRFQEWCSVILCFSLIAHNLVHLLLLARWEHTPLVILGVVAGALVADFLSGLVHWGADTWGSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTQSPETLEQLYPWECFVFCLTIFGTFTNQIHKWSHTYLGLPYWVTVLQDWHVILPRKHHRIHHVAPHETYFCITTGWLNYPLEVIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/33615", 
                    "id": "33615", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A5PLL7/", 
                    "id": "A5PLL7", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155977.1", 
        "ac": "NP_001155977.1", 
        "name": "transmembrane protein 189 isoform 2", 
        "summary": "Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5PLL7", 
                                "id": "A5PLL7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum", 
                        "id": "GO:0005783"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5PLL7", 
                                "id": "A5PLL7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5PLL7", 
                                "id": "A5PLL7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/387521", 
            "id": "387521", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=16735", 
            "id": "16735", 
            "database": "HGNC"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF10520", 
            "id": "PF10520", 
            "database": "Pfam"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240849", 
            "id": "ENSG00000240849", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TMEM189", 
            "id": "TMEM189", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155977.1", 
            "id": "NP_001155977.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:387521", 
            "id": "hsa:387521", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:387522", 
            "id": "hsa:387522", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A5PLL7", 
            "id": "A5PLL7", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A5PLL7", 
            "id": "NX_A5PLL7", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5PLL7", 
            "id": "PR_A5PLL7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A5PLL7*", 
            "id": "A5PLL7", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/387522", 
            "id": "387522", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019547", 
            "id": "IPR019547", 
            "database": "InterPro"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/RTQECIC/", 
            "id": "RTQECIC", 
            "database": "OMA"
        }
    ], 
    "expression_disease": [
        {
            "name": "Lung squamous cell carcinoma [DO disease name]", 
            "trend": "Up", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "Lung squamous cell carcinoma"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3907", 
            "significant": "Yes"
        }, 
        {
            "name": "Lung adenocarcinoma [DO disease name]", 
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "Lung adenocarcinoma"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3910", 
            "significant": "No"
        }, 
        {
            "name": "Liver cancer [DO disease name]", 
            "trend": "Up", 
            "icd10": "C22.0", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "Liver cancer"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3571", 
            "significant": "No"
        }, 
        {
            "name": "Thyroid gland cancer [DO disease name]", 
            "trend": "Up", 
            "icd10": "C73", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid gland cancer"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:1781", 
            "significant": "Yes"
        }, 
        {
            "name": "Esophageal cancer [DO disease name]", 
            "trend": "Up", 
            "icd10": "C15.3", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "Esophageal cancer"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:5041", 
            "significant": "Yes"
        }, 
        {
            "name": "Prostate cancer [DO disease name]", 
            "trend": "Down", 
            "icd10": "C61", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "Prostate cancer"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:10283", 
            "significant": "Yes"
        }, 
        {
            "name": "Urinary bladder cancer [DO disease name]", 
            "trend": "Up", 
            "icd10": "C67", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "Urinary bladder cancer"
            }, 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5PLL7", 
                    "id": "A5PLL7", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:11054", 
            "significant": "Yes"
        }
    ], 
    "glycosylation": [], 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 31135.0, 
        "chemical_mass": 31135.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240849", 
                    "id": "ENSG00000240849", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
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                {
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                {
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        {
            "tissue": {
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                {
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            "tissue": {
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                {
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        {
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        {
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                    "id": "ENSG00000240849", 
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        {
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        {
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                "name": "Prostate gland"
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                    "id": "ENSG00000240849", 
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        {
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        {
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    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A5PLL7", 
            "": "", 
            "name": "TMEM189; KUA", 
            "locus": {
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                "start_pos": 50153734, 
                "chromosome": "20", 
                "evidence": [
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                        "database": "Ensembl Gene"
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                ]
            }
        }
    ]
}