{
    "uniprot_canonical_ac": "A2VCV8-1", 
    "synonyms_protein_refseq": [
        "max-like protein X", 
        "max-like factor protein; transcription factor-like 4; MLX, MAX dimerization protein"
    ], 
    "sequence": {
        "header": "tr|A2VCV8-1|A2VCV8_RAT Isoform 1 of MAX-like protein X, isoform CRA_a  OS=Rattus norvegicus OX=10116 GN=Mlx PE=1 SV=1 CANONICAL=A2VCV8-1", 
        "length": 298, 
        "sequence": "MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSRPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQESYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY"
    }, 
    "uniprot_id": "A2VCV8_RAT", 
    "synonyms_gene_uniprotkb": [
        "Mlx", 
        "rCG_32676"
    ], 
    "enzyme_annotation": [], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                    "id": "A2VCV8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "MAX-like protein X, isoform CRA_a; MAX dimerization protein MLX; MAX-like protein X", 
        "short": ""
    }, 
    "publication": [
        {
            "title": "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11230181", 
            "journal": "Human molecular genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A", 
            "date": "2001", 
            "pmid": "11230181"
        }, 
        {
            "title": "Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16644726", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Xu J, Christian B, Jump DB", 
            "date": "2006", 
            "pmid": "16644726"
        }, 
        {
            "title": "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/10918583", 
            "journal": "Oncogene", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A", 
            "date": "2000", 
            "pmid": "10918583"
        }, 
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                    "id": "A2VCV8", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012", 
            "pmid": "22673903"
        }, 
        {
            "title": "ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16885160", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ma L, Robinson LN, Towle HC", 
            "date": "2006", 
            "pmid": "16885160"
        }, 
        {
            "title": "A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12446771", 
            "journal": "Molecular and cellular biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Eilers AL, Sundwall E, Lin M, Sullivan AA, Ayer DE", 
            "date": "2002", 
            "pmid": "12446771"
        }, 
        {
            "title": "MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11073985", 
            "journal": "Molecular and cellular biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Billin AN, Eilers AL, Coulter KL, Logan JS, Ayer DE", 
            "date": "2000", 
            "pmid": "11073985"
        }
    ], 
    "uniprot_ac": "A2VCV8", 
    "synonyms_gene_refseq": [
        "Mlx", 
        "Tcfl4"
    ], 
    "mutation": [], 
    "synonyms_protein_uniprotkb": [
        "MAX-like protein X, isoform CRA_a", 
        "MAX dimerization protein MLX", 
        "MAX-like protein X"
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VCV8#A2VCV8-1", 
            "isoform_ac": "A2VCV8-1", 
            "locus": {
                "end_pos": 88997439, 
                "start_pos": 89001157, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000027116", 
                        "id": "ENSRNOT00000027116", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000027116", 
                        "id": "ENSRNOP00000027116", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2VCV8-1|A2VCV8_RAT Isoform 1 of MAX-like protein X, isoform CRA_a  OS=Rattus norvegicus OX=10116 GN=Mlx PE=1 SV=1 CANONICAL=A2VCV8-1", 
                "length": 298, 
                "sequence": "MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSRPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQESYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360631", 
            "resource": "KEGG Pathway", 
            "id": "rno:360631", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163765", 
            "resource": "Reactome", 
            "id": "R-RNO-163765", 
            "name": "ChREBP activates metabolic gene expression"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
            "annotation": "ChREBP.Mlx is the principal transcription factor regulating glucose-responsive genes in the liver and coordinately regulates a family of genes required for glucose utilization and energy storage", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
            "annotation": "Involved in control of hepatic L-type pyruvate kinase gene transcription", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
                    "id": "NP_001029284.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9UH92-1", 
            "protein_name": "Max-like protein X; Class D basic helix-loop-helix protein 13; bHLHd13; Protein BigMax; Max-like bHLHZip protein; Transcription factor-like protein 4", 
            "sequence": {
                "length": 298, 
                "sequence": "MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2VCV8/", 
                    "id": "A2VCV8", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/7969", 
                    "id": "7969", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "O08609-1", 
            "protein_name": "Max-like protein X; Protein BigMax; Max-like bHLHZip protein; Transcription factor-like protein 4", 
            "sequence": {
                "length": 298, 
                "sequence": "MTEPGASPEDPWVKASFADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSGARGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/7969", 
                    "id": "7969", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
        "ac": "NP_001029284.1", 
        "name": "max-like protein X", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA-binding transcription factor activity", 
                        "id": "GO:0003700"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein homodimerization activity", 
                        "id": "GO:0042803"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein heterodimerization activity", 
                        "id": "GO:0046982"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor binding", 
                        "id": "GO:0008134"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II regulatory region sequence-specific DNA binding", 
                        "id": "GO:0000977"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", 
                        "id": "GO:0001227"
                    }
                ], 
                "total": 6, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear membrane", 
                        "id": "GO:0031965"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription by RNA polymerase II", 
                        "id": "GO:0006357"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VCV8", 
                                "id": "A2VCV8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 256, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 254
        }
    ], 
    "crossref": [
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15741:SF25", 
            "id": "PTHR15741:SF25", 
            "database": "PANTHER"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/360631", 
            "id": "360631", 
            "database": "GeneID"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/AHNTEDE/", 
            "id": "AHNTEDE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284.1", 
            "id": "NP_001029284.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00083", 
            "id": "cd00083", 
            "database": "CDD"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019983", 
            "id": "ENSRNOG00000019983", 
            "database": "Bgee"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00010", 
            "id": "PF00010", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360631", 
            "id": "rno:360631", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032647", 
            "id": "IPR032647", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", 
            "id": "IPR036638", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", 
            "id": "IPR011598", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163765", 
            "id": "R-RNO-163765", 
            "database": "Reactome"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308590", 
            "id": "1308590", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 33420.0, 
        "chemical_mass": 33420.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VCV8", 
            "": "", 
            "name": "rCG_32676; Mlx; Tcfl4", 
            "locus": {
                "end_pos": 89002152, 
                "start_pos": 88997399, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019983", 
                        "id": "ENSRNOG00000019983", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}