{ "uniprot_canonical_ac": "A2AT37-1", "synonyms_protein_refseq": [ "regulator of nonsense transcripts 2" ], "sequence": { "header": "tr|A2AT37-1|A2AT37_MOUSE Isoform 1 of UPF2 regulator of nonsense transcripts homolog (Yeast) OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1", "length": 1269, "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKPRDDLKVTAKKEVSKVPEDKKKRLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRYSDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEINDDTLELEGADEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" }, "uniprot_id": "A2AT37_MOUSE", "synonyms_gene_uniprotkb": [ "Upf2" ], "enzyme_annotation": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "UPF2 regulator of nonsense transcripts homolog (Yeast)", "short": "" }, "publication": [ { "title": "NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18483223", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Weischenfeldt J, Damgaard I, Bryder D, Theilgaard-Monch K, Thoren LA, Nielsen FC, Jacobsen SE, Nerlov C, Porse BT", "date": "2008", "pmid": "18483223" }, { "title": "Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25770585", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Li T, Shi Y, Wang P, Guachalla LM, Sun B, Joerss T, Chen YS, Groth M, Krueger A, Platzer M, Yang YG, Rudolph KL, Wang ZQ", "date": "2015", "pmid": "25770585" }, { "title": "Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28444146", "journal": "Biology of reproduction", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "MacDonald CC, Grozdanov PN", "date": "2017", "pmid": "28444146" }, { "title": "UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27149259", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Bao J, Vitting-Seerup K, Waage J, Tang C, Ge Y, Porse BT, Yan W", "date": "2016", "pmid": "27149259" }, { "title": "Staufen1-mediated mRNA decay functions in adipogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22503102", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Cho H, Kim KM, Han S, Choe J, Park SG, Choi SS, Kim YK", "date": "2012", "pmid": "22503102" }, { "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003", "pmid": "12520002" }, { "title": "UPF2 is a critical regulator of liver development, function and regeneration.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20657840", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Thoren LA, Norgaard GA, Weischenfeldt J, Waage J, Jakobsen JS, Damgaard I, Bergstrom FC, Blom AM, Borup R, Bisgaard HC, Porse BT", "date": "2010", "pmid": "20657840" }, { "title": "Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27149095", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Fanourgakis G, Lesche M, Akpinar M, Dahl A, Jessberger R", "date": "2016", "pmid": "27149095" } ], "uniprot_ac": "A2AT37", "synonyms_gene_refseq": [ "Upf2" ], "mutation": [], "synonyms_protein_uniprotkb": [ "UPF2 regulator of nonsense transcripts homolog (Yeast)" ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AT37#F6Q3G7-1", "isoform_ac": "F6Q3G7-1", "locus": { "end_pos": 6023339, "start_pos": 6055441, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000128200", "id": "ENSMUST00000128200", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119348", "id": "ENSMUSP00000119348", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Q3G7-1|A2AT37_MOUSE Computationally mapped isoform of UPF2 regulator of nonsense transcripts homolog (Yeast) OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1", "length": 523, "sequence": "XVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" } }, { "url": "https://www.uniprot.org/uniprot/A2AT37#A2AT37-1", "isoform_ac": "A2AT37-1", "locus": { "end_pos": 5957489, "start_pos": 6055439, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000060092", "id": "ENSMUST00000060092", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000058375", "id": "ENSMUSP00000058375", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AT37-1|A2AT37_MOUSE Isoform 1 of UPF2 regulator of nonsense transcripts homolog (Yeast) OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1", "length": 1269, "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKPRDDLKVTAKKEVSKVPEDKKKRLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRYSDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEINDDTLELEGADEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:326622", "resource": "KEGG Pathway", "id": "mmu:326622", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "resource": "Reactome", "id": "R-MMU-975957", "name": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AT37#function", "annotation": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37#function", "id": "A2AT37", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies . Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "We report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR transcripts, and that this role is independent of its canonical role in degrading 'premature termination codon' (PTC)-containing transcripts in somatic cell lineages Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZT03-1", "protein_name": "UPF2, regulator of nonsense mediated mRNA decay", "sequence": { "length": 1272, "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKSKDDLKITAKKEVSKVPEDKKKKLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLNFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSSKDDSKETGGYEPRNWRNRENENELMLEFESFLRATSTVHYTSSALEKGKRKKRRDEREQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRRKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDDEDEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQFNSGKVEKISELGTPFNVNLESTFHVKPQLRHGERNTRESTDTNIPLYVLSQEHNKKKMFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGR" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AT37/", "id": "A2AT37", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9HAU5-1", "protein_name": "Regulator of nonsense transcripts 2; Up-frameshift suppressor 2 homolog; hUpf2; Nonsense mRNA reducing factor 2", "sequence": { "length": 1272, "sequence": "MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/6101", "id": "6101", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "ac": "NP_001074601.1", "name": "regulator of nonsense transcripts 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "telomeric DNA binding", "id": "GO:0042162" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005844", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "polysome", "id": "GO:0005844" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035145", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "exon-exon junction complex", "id": "GO:0035145" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "liver development", "id": "GO:0001889" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031100", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "animal organ regeneration", "id": "GO:0031100" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "response to unfolded protein", "id": "GO:0006986" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 1085, "annotation": "n_glycosylation_sequon", "start_pos": 1083 }, { "end_pos": 682, "annotation": "n_glycosylation_sequon", "start_pos": 680 }, { "end_pos": 259, "annotation": "n_glycosylation_sequon", "start_pos": 257 }, { "end_pos": 1048, "annotation": "n_glycosylation_sequon", "start_pos": 1046 }, { "end_pos": 336, "annotation": "n_glycosylation_sequon", "start_pos": 334 }, { "end_pos": 664, "annotation": "n_glycosylation_sequon", "start_pos": 662 }, { "end_pos": 198, "annotation": 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