{ "uniprot_canonical_ac": "A4UGR9-1", "sequence": { "header": "sp|A4UGR9-1|XIRP2_HUMAN Isoform 1 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 3374, "sequence": "MSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGVPSGRQAEFS" }, "uniprot_id": "XIRP2_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "xin actin-binding repeat-containing protein 2 isoform 2", "xeplin; xin actin-binding repeat-containing protein 2; cardiomyopathy associated 3; xin repeat protein 2; beta-xin; cardiomyopathy-associated protein 3; myomaxin" ], "uniprotkb": [ "Xin actin-binding repeat-containing protein 2", "Xeplin", "Cardiomyopathy-associated protein 3", "Beta-xin" ] }, "gene": { "refseq": [ "XIRP2", "CMYA3" ], "uniprotkb": [ "XIRP2", "CMYA3" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Xin actin-binding repeat-containing protein 2; Xeplin; Cardiomyopathy-associated protein 3; Beta-xin." }, "publication": [ { "title": "Critical Roles of Xirp Proteins in Cardiac Conduction and Their Rare Variants Identified in Sudden Unexplained Nocturnal Death Syndrome and Brugada Syndrome in Chinese Han Population.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29306897", "journal": "Journal of the American Heart Association", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Huang L, Wu KH, Zhang L, Wang Q, Tang S, Wu Q, Jiang PH, Lin JJ, Guo J, Wang L, Loh SH, Cheng J", "date": "2018", "pmid": "29306897" }, { "title": "Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26566883", "journal": "J. Med. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "authors": "Wiemann S., Rappold G.A., Wade R.C., Aslamkhan M., Berkel S., Mustafa G., Paramasivam N., Rafiullah R., Schlesner M., Thiel C.", "date": "2016", "pmid": "26566883" }, { "title": "A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25865352", "journal": "The Journal of allergy and clinical immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Schaarschmidt H, Ellinghaus D, Rodriguez E, Kretschmer A, Baurecht H, Lipinski S, Meyer-Hoffert U, Harder J, Lieb W, Novak N, Folster-Holst R, Esparza-Gordillo J, Marenholz I, Ruschendorf F, Hubner N, Reischl E, Waldenberger M, Gieger C, Illig T, Kabesch M, Zhang XJ, Xiao FL, Lee YA, Franke A, Weidinger S", "date": "2015", "pmid": "25865352" }, { "title": "CCDD Phenotype Associated with a Small Chromosome 2 Deletion.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24475916", "journal": "Seminars in ophthalmology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Abu-Amero KK, Bosley TM, Kondkar AA, Oystreck DT, Khan AO", "date": "2015", "pmid": "24475916" }, { "title": "Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20520587", "journal": "Psychiatric genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Nielsen DA, Ji F, Yuferov V, Ho A, He C, Ott J, Kreek MJ", "date": "2010", "pmid": "20520587" }, { "title": "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16205742", "journal": "European journal of human genetics : EJHG", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Blasi F, Bacchelli E, Carone S, Toma C, Monaco AP, Bailey AJ, Maestrini E", "date": "2006", "pmid": "16205742" }, { "title": "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17046827", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ", "date": "2006", "pmid": "17046827" }, { "title": "Xin repeats define a novel actin-binding motif.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15454575", "journal": "J. Cell Sci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Rottner K., Fuerst D.O., Vakeel P., van der Ven P.F.M., Himmel M., Loewe T., Pacholsky D., Stradal T.", "date": "2004", "pmid": "15454575" }, { "title": "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14687087", "journal": "Animal genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Pan PW, Li K, Tuggle CK, Yu M, Liu B, Zhao SH", "date": "2003", "pmid": "14687087" }, { "title": "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12203715", "journal": "Developmental dynamics : an official publication of the American Association of Anatomists", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ], "authors": "Sinn HW, Balsamo J, Lilien J, Lin JJ", "date": "2002", "pmid": "12203715" } ], "glycosylation": [ { "residue": "Thr", "evidence": [ { "url": "https://data.glygen.org/GLYDS000142", "id": "GLYDS000142", "database": "GlyGen" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29351928", "id": "29351928", "database": "PubMed" } ], "relation": "attached", "position": 2838, "glytoucan_ac": "G70994MS", "type": "O-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-1", "isoform_ac": "A4UGR9-1", "locus": { "end_pos": 167136026, "start_pos": 167254123, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000628543", "id": "ENST00000628543", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000486198", "id": "ENSP00000486198", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4UGR9-1|XIRP2_HUMAN Isoform 1 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 3374, "sequence": "MSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGVPSGRQAEFS" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A0A0A0MQZ3-1", "isoform_ac": "A0A0A0MQZ3-1", "locus": { "end_pos": 167249151, "start_pos": 167254123, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000295237", "id": "ENST00000295237", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000295237", "id": "ENSP00000295237", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MQZ3-1|XIRP2_HUMAN Computationally mapped isoform of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=1 CANONICAL=A4UGR9-1", "length": 963, "sequence": "MPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGVPSGRQAEFS" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-2", "isoform_ac": "A4UGR9-2", "locus": { "end_pos": 167210839, "start_pos": 167254123, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000409273", "id": "ENST00000409273", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000387255", "id": "ENSP00000387255", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4UGR9-2|XIRP2_HUMAN Isoform 2 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 3327, "sequence": "MARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGVPSGRQAEFS" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-3", "isoform_ac": "A4UGR9-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A4UGR9-3|XIRP2_HUMAN Isoform 3 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 3345, "sequence": "MSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISGK" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-4", "isoform_ac": "A4UGR9-4", "locus": { "end_pos": 166903483, "start_pos": 167259360, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000409043", "id": "ENST00000409043", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000386454", "id": "ENSP00000386454", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4UGR9-4|XIRP2_HUMAN Isoform 4 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 938, "sequence": "MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPTSLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSVFEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKKLLLQDKEICILCQKTVYPMECLVADKQNFHKSCFRCHHCNSKLSLGNYASLHGQIYCKPHFKQLFKSKGNYDEGFGHKQHKDRWNCKNQSRSVDFIPNEEPNMCKNIAENTLVPGDRNEHLDAGNSEGQRNDLRKLGERGKLKVIWPPSKEIPKKTLPFEEELKMSKPKWPPEMTTLLSPEFKSESLLEDVRTPENKGQRQDHFPFLQPYLQSTHVCQKEDVIGIKEMKMPEGRKDEKKEGRKNVQDRPSEAEDTKSNRKSAMDLNDNNNVIVQSAEKEKNEKTNQTNGAEVLQVTNTDDEMMPENHKENLNKNNNNNYVAVSYLNNCRQKTSILEFLDLLPLSSEANDTANEYEIEKLENTSRISELLGIFESEKTYSRNVLAMALKKQTDRAAAGSPVQPAPKPSLSRGLMVKGGSSIISPDTNLLNIKGSHSKSKNLHFFFSNTVKITAFSKKNENIFNCDLIDSVDQIKNMPCLDLREFGKDVKPWHVETTEAARNNENTGFDALSHECTAKPLFPRVEVQSEQLTVEEQIKRNRCYSDTE" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-5", "isoform_ac": "A4UGR9-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A4UGR9-5|XIRP2_HUMAN Isoform 5 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 763, "sequence": "MSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKKLLLQDKEICILCQKTVYPMECLVADKQNFHKSCFRCHHCNSKLSLGNYASLHGQIYCKPHFKQLFKSKGNYDEGFGHKQHKDRWNCKNQSRSVDFIPNEEPNMCKNIAENTLVPGDRNEHLDAGNSEGQRNDLRKLGERGKLKVIWPPSKEIPKKTLPFEEELKMSKPKWPPEMTTLLSPEFKSESLLEDVRTPENKGQRQDHFPFLQPYLQSTHVCQKEDVIGIKEMKMPEGRKDEKKEGRKNVQDRPSEAEDTKSNRKSAMDLNDNNNVIVQSAEKEKNEKTNQTNGAEVLQVTNTDDEMMPENHKENLNKNNNNNYVAVSYLNNCRQKTSILEFLDLLPLSSEANDTANEYEIEKLENTSRISELLGIFESEKTYSRNVLAMALKKQTDRAAAGSPVQPAPKPSLSRGLMVKGGSSIISPDTNLLNIKGSHSKSKNLHFFFSNTVKITAFSKKNENIFNCDLIDSVDQIKNMPCLDLREFGKDVKPWHVETTEAARNNENTGFDALSHECTAKPLFPRVEVQSEQLTVEEQIKRNRCYSDTE" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-6", "isoform_ac": "A4UGR9-6", "locus": { "end_pos": 166903483, "start_pos": 167259360, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000409728", "id": "ENST00000409728", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000386619", "id": "ENSP00000386619", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4UGR9-6|XIRP2_HUMAN Isoform 6 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 971, "sequence": "MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPTSLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSVFEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPESGHSRIFEAVFSTDQAQILRLHLHPKLTKTPKNSLKSSTYISTAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKKLLLQDKEICILCQKTVYPMECLVADKQNFHKSCFRCHHCNSKLSLGNYASLHGQIYCKPHFKQLFKSKGNYDEGFGHKQHKDRWNCKNQSRSVDFIPNEEPNMCKNIAENTLVPGDRNEHLDAGNSEGQRNDLRKLGERGKLKVIWPPSKEIPKKTLPFEEELKMSKPKWPPEMTTLLSPEFKSESLLEDVRTPENKGQRQDHFPFLQPYLQSTHVCQKEDVIGIKEMKMPEGRKDEKKEGRKNVQDRPSEAEDTKSNRKSAMDLNDNNNVIVQSAEKEKNEKTNQTNGAEVLQVTNTDDEMMPENHKENLNKNNNNNYVAVSYLNNCRQKTSILEFLDLLPLSSEANDTANEYEIEKLENTSRISELLGIFESEKTYSRNVLAMALKKQTDRAAAGSPVQPAPKPSLSRGLMVKGGSSIISPDTNLLNIKGSHSKSKNLHFFFSNTVKITAFSKKNENIFNCDLIDSVDQIKNMPCLDLREFGKDVKPWHVETTEAARNNENTGFDALSHECTAKPLFPRVEVQSEQLTVEEQIKRNRCYSDTE" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-7", "isoform_ac": "A4UGR9-7", "locus": { "end_pos": 167210839, "start_pos": 167259360, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000409605", "id": "ENST00000409605", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000386981", "id": "ENSP00000386981", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4UGR9-7|XIRP2_HUMAN Isoform 7 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 716, "sequence": "MARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKKLLLQDKEICILCQKTVYPMECLVADKQNFHKSCFRCHHCNSKLSLGNYASLHGQIYCKPHFKQLFKSKGNYDEGFGHKQHKDRWNCKNQSRSVDFIPNEEPNMCKNIAENTLVPGDRNEHLDAGNSEGQRNDLRKLGERGKLKVIWPPSKEIPKKTLPFEEELKMSKPKWPPEMTTLLSPEFKSESLLEDVRTPENKGQRQDHFPFLQPYLQSTHVCQKEDVIGIKEMKMPEGRKDEKKEGRKNVQDRPSEAEDTKSNRKSAMDLNDNNNVIVQSAEKEKNEKTNQTNGAEVLQVTNTDDEMMPENHKENLNKNNNNNYVAVSYLNNCRQKTSILEFLDLLPLSSEANDTANEYEIEKLENTSRISELLGIFESEKTYSRNVLAMALKKQTDRAAAGSPVQPAPKPSLSRGLMVKGGSSIISPDTNLLNIKGSHSKSKNLHFFFSNTVKITAFSKKNENIFNCDLIDSVDQIKNMPCLDLREFGKDVKPWHVETTEAARNNENTGFDALSHECTAKPLFPRVEVQSEQLTVEEQIKRNRCYSDTE" } }, { "url": "https://www.uniprot.org/uniprot/A4UGR9#A4UGR9-8", "isoform_ac": "A4UGR9-8", "locus": { "end_pos": 166903483, "start_pos": 167254123, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000409195", "id": "ENST00000409195", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000386840", "id": "ENSP00000386840", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4UGR9-8|XIRP2_HUMAN Isoform 8 of Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 CANONICAL=A4UGR9-1", "length": 3549, "sequence": "MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLLAPEGEVVSAPQSLDPTSLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLSSRRRIERFSIALDELRSVFEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDSVKDSDKKGKETSFDKMSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGVPSGRQAEFS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:129446", "resource": "KEGG Pathway", "id": "hsa:129446", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9#function", "annotation": "Protects actin filaments from depolymerization.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9#function", "id": "A4UGR9", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "annotation": "Report pathogenic XIRP1/2 rare variants in arrhythmogenic disorders such as sudden unexplained nocturnal death syndrome and Brugada syndrome. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "annotation": "A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis, XIRP2 and DMRTA1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "annotation": "Genetic information from this patient implies that genes involved in development and maintenance of extraocular muscles can cause congenital ocular motility disorders as well.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "annotation": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "annotation": "Xin and XIRP2 define a novel actin-binding motif", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q4U4S6-1", "protein_name": "Xin actin-binding repeat-containing protein 2; mXinbeta; Myogenic MEF2-activated Xin-related protein; Cardiomyopathy-associated protein 3; Beta-xin; Myomaxin.", "sequence": { "length": 3784, "sequence": "MARYQAAVSRGDTRSFSANVMEESDVCTVPGGLAKMKRQFEKDKMTSTCNAFSEYQYRHESRAEQEAIHSSQEIIRRNEQEVSKGHGTDVFKAEMMSHLEKHTEETKQASQFHQYVQETVIDSPEEEELPKVSTKILKEQFEKSAQENFLRSDKETSPPAKCMKIENDIEETLKPSSAVGTSSSYTSTRQRKETSTSSYSNHSLTSTTLAQDNGTPSGKMEEFPPPPPDVCQTPMDVTAFSQSPEFPSPPRRLPMPKDLYSKQRNLYELNRLYRHIHPELRKNLEKDYISEVSEIVSSQINSGNALSADVQKARYVFENTNDSSQKDLNSERENLEWDEILKGEVQSIRWIFENQPLDSINHGSTDEGYTSKGIADQELIAGSDVKYTTWMFETQPIDALGIPSAGTEGNTEKIPELARGDVYTARWMFETRPLDSMNKMHECQEETASTLTKDITGGDVKTVRYMFETQQLDQLGQLHSVDELNLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVQREDIEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSRAKWLFETQPLEKIKEESGEAVLKTEAVIGTDVSKKCWMFETQPLDILKDSPDTDSVSPEERIGGDVKTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVKHQKWVFETQRLEDIREDKKEYTRTVRLEAVDRGHVKNYTHIFESNNLIKVDASHQIEVEGVTRGTVELNKSLFETTPLYAIQDHLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESLHKFQIIRGISAQEIQAGNVKSARWLFETQPLDSIKYFSNVEETDSKTEQSTDIVKGDVKTCKWLFETQPMESLYEKASLMTNSEDIHKGDVRTCMWLFETQPLDAIKDDSEATVKLQTVKQEEIQGGDVQTACFLFETENLDNIQGDEGKENKPLEMDIQSGDVSGMKFKFENQSLDSINCSSENVLSKIKTLKAEDIQKGNVLKCRWLFENQPIDMIKESQECDGLVKTVTDVQGGDVRKGCFIFETFSLDEIKDESDGISMRETNLGEIIKGDVKSYKMLFETQPLYAIQDHEGFYHEVTTVKKEETIHGDVRGTRWLFETKPLDSIHESEDVYVIKSVTQEDIQKGDVSSVRYRFETQPLDMISDKSHNIVPTVDYIQGGNVQMNKQLFESEGGNKKNYVRTVSVNEIQKGNVKTSTWLFETHRIDELGEESRYENIKTVTQEDVQKGDVKQAVWLFENQTLDSINELDENDTKMTKEEIPPSDVKTTTWLFETTPIHEFNKTRVEKEEIIGKSIKETLEDLYSQRVVEAPGIIIEADEVGDVRMAKYKLMNQTTPEIQKEEVIRADLGNIMMNLLSQRDCTKKEIFVSEEEKGNVNFTKTQLLNRSMEFHAEKEEIVRGDVKQAIQKLFSEERRAKKGILIQEDEKGDINMTIYCLLHENAGDKTEREDILGGDVRRTIHNLLSSASNGKISERTKIDASERGNVQFFTTCIETGALDYLKQLQTGSNESTLTASKQEGEEEIIGGDVEGTKFLLKKRQSSFERTVSETDIIPGDVRHTVKVFMTEPQSSSYKTVKDEIIKGDLKSTLNSLNQAMNQKTVAKAEEIVKDDRLAILKSLKESGDRQKEPKQSGGMSRDIGQAIECLERATNTRTEILKKELILDDLKTSLRSLKEEQCGFKEVDKQGIVKDVLPGMLGFSERPKIGIHPAAVQRDKKSLLQPVPGPFEPAIKQQAGPGTLDETTQKPCLRSLIEERTEANLPKAPKGTVKIVIDREQNNDALEKSLRKMSNSEHRAMKNVLDMSDRMGIWTESKEYLCSDDHMSKHLSATMSIKESLKSKESENMREAKDDVISSTQSVDKTFRKQQTQTCELGNDQKSRFQDSYGKNQKNIQNIEITRDFQKQALLSQEKQYSNKEMKKNEASLQPLPVGKEVHSVPGVTVSGKNHKRIQATDKRQKTDVCLESQDFLMKTNTSKELKMAMERSFNPINLHPECGIKENEDSLPPPSPPPLPPSNASSEIEFPLPPPPPLMLLPGKNESPPSSPTEKTRTEFESLSTLPLPPPPVDEKAEQECLSTTLPPPPPPTPCQPGHLLPSSVLGHHREAFLQQFSQKEALGVHLPHSQAKILTGKSPPPTLPKPKLPKRIKDKMNQYSSSGELERSLSDVEIKATLSKDQKRSMVTMSSEHRETKQDVFGKGLVGRKQLPVDSANSLSQTVPEIPAPKEKQTAPLVKSHSFPSGSEQQSPKPYMRKFKTPLMIAEEKYRQQREELEKQRQESSSHNVIKTETQHQSLSEKEEEIELQKATEAISTPRKESDFPRARPNLDSESRAVIAGECSESQLATASTLTVATERLQHVLAASEDELTLRQEGIQNSSDASQSKLACETSQSHKECKAQQTFEQHVKRLPFPQTKPSSPSFKVKTIKLSTLDHTGTETDLSSKHHTKQSEVDIQTSTEQTDKEIKKTQASIQCDDKPSVPEKYFQLPKTEKRVTIQMPKEYAEKSHKSKLQTVPKKQGIFGEFDRGNVLGREGKNQDSSVSCSKEDRLIDERKQEHLQNQRVPRSVQQKVINERLDSQMQNFQQTEIQTSRSTIECEEFSQSYNATQEKTCLKDKGKQQGQVTSNTEESKQELRQNQSAFSSVKDSQHDDGKCTINILEFLRKREELQQILSRVKQFEAESSKSGLKTFQILLNIVPVWLISEEKREYGVRVAMENNFEKVKEEITHIKTQAEEMLLQCEHVIQTAMMASQTGKQRDKPTNLNEMPLNVSNVNLSSSKCTEQKESKTVEEKLTHRQVTTHPEAATRNPVKPYQEAKGEDGKMAPPSLKTRPPSPTFITIESTARRAETSTKSELSQSPKNNRCIEPPPRRPVEHASGLPRSRTPPSPPRSRSEQLVRLKDTTARLAKGTIPCSPGTPVPIVEKRSEVVMSPATLRRQIKIESRGGDSPPTITIPVSVNHVVSGSFRESVDAQEAVKKTEKTETYVHKDKMNSVNRAMPETESYDAVEIIRKVEGPHLSEHTERFEATNQTVQRAERFLNGHENEINRWFREFENDPVFRAKTERGAYANGEINHNMKQESHTFCKEEFGLASSETANFTGFSYRHPKVPAMQPRVHSEARSLNEHFSSVDAFDSQIVGSKVATSSSRSTEAGRSGFDFKHAPPTYEDVISGHILDVADSPTNLRRNFQKTWQESERVFQRVGYETSDAHATEMSRAFQEESAFLSDKEICIICQKTVYPMECLIADKQNFHKSCFRCHHCSSKLSLGNYASLHGRIYCKPHFKQLFKSKGNYDEGFGHKQHKDRWNCKNQSSLVDFIPSGEPDAHENPTADTLLLGDLTTHPDACNSKRQDNDLRKWGDRGKLKIVWPPCQEMPKKNSPPEEEFKVNKAKWPPEVTIPVPSDFKRESLTEHVKTLESQGQEQDSVPDLQPCKHVCQKEDITGIKEIKGYEERKDEKEAKDTLKDAEGLRSKRKSGMEFNDHNAHAQSDGKEKNALVNEADSADVLQVANTDDEGGPENHRENFNNNNNNSVAVSSLNNGRQKISISERPRLLQAVSEANYYTSEYQIKNFNNASKISELLGIFESQKLSSKKVLALALERTADRGTAGSPLQLVLEPGLQQGFSVKGENLAASPDVSPLHIKGNHENNKNVHLFFSNTVKITSFSKKHNILGCDLMDSVDQLKNMSCLYLRELGKNVKCWHGETAGAARHGGKMCFDAQSQGSAAKPVFPSMQCQAQHLTVEEQIKRDRCYSDSEAD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19388", "id": "19388", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q71LX6-1", "protein_name": "Xin actin-binding repeat-containing protein 2; L-NAME-induced actin cytoskeletal protein; Cardiomyopathy-associated protein 3; Beta-xin.", "sequence": { "length": 3302, "sequence": "MARYQAAVSRGDTRSFSANVMEESDLCTVPGGLAKMKRQFEKDEMTSTCNAFSEYQYQHESRSEQEAIHNRQEIRRNEEEVSKGHRTDVFKAEMMSHLEKHTEETNQASQFRQYVQETVIDTPEDEEIPKVSTKILKEQFEKTAQENFLYSDKETTTPAKCIKIENDSEETLKPSSAMGTSSYTSARQSKETSTSSYSNHSLTSTILAQEKGTPSGKMEEFPPPPPDVFQTPMDVTAFSQSPEFPSPPRRLPMPRDVYSKQRNLYELNRLYRHIHPELRKNLEKDYISEVSEIVSSHINSGNSISAGVQQARYVFENTNDSSQKDLSSERENLEWDEILKGEVQSIRWIFENQPLDSINQGFTDEAYTSKGIADQELIAGGDVKYTTWMFETQPIDALGVPSAGTEENTEKIPELAKGDVCTARWMFETRPLDSMNKMHEWEDETASTFIKDITGGDVKTVRYMFETQQLDQLGQLHSVDEMNLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVQREDIEKGDVRTARWMFETQPLDTIKQDITEIKVVRGISMEENVKGEVGRARWLFETQPLEKIKEESGEAVLKTEAVVGIDVSKKCWMFETQPLDTLKQSPDTESVSPEERIGGDVKTTKHLLETLPIEALKDSPDVGKLQKITASEEEKGDVKHQKWVFETQRLEDIREDKKEYTQTVKLEAVDRGHVKNYTHIFESNNLIKVDASHQIEVEGVTRGTVELNKSLFETTPLYAIQDHLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESLHKFQIIRGISAQEIQAGNVKSARWLFETQPLDSIKYFSNVEETDSKTEQSTDIVKGDVKTCKWLFETQPMESLYEKASLMTNSEDIHKGDVRTCMWLFETQPLDAIKNDSEATVKLQTVKQEEIQGGDVRTACLLFETENLDNIQGGEGKETKPVEMDIESGDVSGMKYKFENQSLDSISCSSENVLNKIKTLKIEDIQKGNVLNCRWLFENQPIDMIKENQEGDGLVKTVTDIQGGDVRKGCFIFETFSLDEIKDESDVISTRQTNTEEVIKGDVKSYKMLFETQPLYAIQDQEGFYHEVTTVKKEETIHGDVRGTRWLFETKPLDSINASEDVYIIKSVTQEDIQKGDVSSVRYRFETQPLDMISDKSHNIMPTIDHIQGGNVQMNKQLFESEGGDKKNYVRTVSINEIQKGNVKTSTWLFETHSIDELGEVSTYENIKTVTQEDVQKGDVKQAVWLFENQTLDSIKELDESDTKITKEEIPPSDVKTTTWLFETTPIHEFNETRIEKEEIIGKSIKETLEDLYSQRVVEAPGIIIEADEVGDVRMAKYKLMNQRTPEIQKEEVIRADLGNIMMNLLSQRDCTKKEIFISEEEKGNVNFTKTQLLNRSMEFHAEKEEIVRGDVKQAIQKLFSEERCAKRGILIQEDEKGDVNMTIYCLLHENAGDKTKREDILGGDVRRTIHNLLSSASNDKISERTKIDASERGNVQFFTTCIETGALDYLKQLQTGSNETLTARKQEGEEEIIGGDVEGTKFLLKKRQSSIERTVSETDIIPGDVRNTVKVFMTEPQSASFKTAKEEIVKGDLKSTLNSLNQAMNQKVVAKTEDIMKDDKAAILKSLKESGGRQKEHKQSASISSDIGQAIECLEKATNTRTEILKKELILDDLKTSLRSLKEEQYSFKEVGKQGMVKDVLGFSERQELGIHPAAVQREKKSLLQPVPGPCEPAIRQQAGPGPLDEATQKSCHRSLTEERTEANLPKAPKGTVKIVIDREQNNDALEKSLRKMSNSEHRAMKNVLDMGDRRGVWTESKECLCSDDHMSKYVSASMSRKKSLKTKESENVRESKDDVSSTQSVDKTFRKQQTQNCELGKDHQKSQFQDSYAKNQKNTQNISMSAETQSYRPDPTQHPVSNPAGETLEMTRDFQKQALIRQEKQNSNKDMRKNDMGLQPLPVGKDAHSAPGVTVSGKNHKRTQAPDKKQRIDVCLESQDFLMKTNTSKELKMAMERSFNPVNLYPDCGVKENEDALPPPSPPPPPPSNASSEIEFPLPPPPPIMLLPEKNEFPPSSPTEKSRAELESLPTLPLPPPPGDEKSDQECLPTSLPPPPPTAPSQPAHLLSSSVLEHHSEAFLQQYSRKETLDSHQLHSQAKILTGKSPPPTLPKPKLPERIKAKMSQDSPSGELERSLSDVEIKTTLSKDQKSSLVAESREHTEAKQEVFRKSLGRKQLSISSANSLSQTVPEIPAPKEKQTAPLVKSHSFPSGSEQQSPKPYMRKFKTPLMIAEEKYRQQREELEKQRRESSCHSIIKTETQHRSLSEKEKETELQKAAEAMSTPRKDSDFTRAQPNLEPKSKAVIASECSESQLSTASALTVATERLQHVLAASDDKLTLRREGTQNSSDTLQSKTACEINQSHKECRTEQTFEQHVEKLPFPQTKPISPSFKVKTIRLPALDHTLTETDLSSERRVKQSEIDVQTSTKEMNKEIKKTEVSTQCDNKQSVAEKYFQLPKTEKRVTVQMPKDYAAKSHQSKLQTVPKKHGGLGEFDRGNVLGREGKNQDSSMSSTKESRVIVERKQEHLQDQSVPRLVQQKIIGESLDSRVQNFQQTQTQTSRIEHKELSQPYSEKKCLRDKDKQQKQVSSNTDDSKQEITQKQSSFSSVRESQQDGEKCAINILEFLRKREELQQILSRVKQFEADSNKSGLKTFQTLLNIAPVWLISEEKREYGVRVAMENNLEKVKEEIIHIKTQAEEMLVHCEHVIRTAMMASQTGKQKDKPTNLNEMPLKVSNVNLSSHKGTEQKESKIVEEKLASRQVATHSEAATHNPAKTYQEAKGDDSKMAPPSLKTRPPSPTFITIESTARRAETSTKSELSQSPKNNSCVEPLPRRPMEHTSRLPRTSTSPSPPRSRSEQLVRLKDTTARLAKGTIPCSPGTPVPVVEKRSEVVMSPATLRRQIKIESRGGDSPPTITIPVSVNHHVVSGSFRESVDAQEAVKKTEKTETYVHKDKKNSVSSAMPETESYDAVEIIRKVEGPHLSEHRERFEATNQTVQMAEHFLNGHENEVNRWFREFENGPVFGAKTERRAYANGEINHNMKQESHTFCKEEFGLESSETANFTGFSYRHPREHRAKAPATQPRVHSEARALNEHFLSVDAFDSQIVESQVATSSSRSSEAGRSGFDFKHAPPTYEDVIAGHILDIADSPTNLRRNFQKTWQESERVFKSVGYETSDAHATEMSRAFQEELAFLSETVGPRQGNLHNLSKDGLSNGVPRSRPAEFS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19388", "id": "19388", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "ac": "NP_001073278.1", "name": "xin actin-binding repeat-containing protein 2 isoform 2; xeplin; xin actin-binding repeat-containing protein 2; cardiomyopathy associated 3; xin repeat protein 2; beta-xin; cardiomyopathy-associated protein 3; myomaxin.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "actin filament binding", "id": "GO:0051015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051393", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "alpha-actinin binding", "id": "GO:0051393" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "cell junction", "id": "GO:0030054" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "Z disc", "id": "GO:0030018" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "actin cytoskeleton organization", "id": "GO:0030036" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055008", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "cardiac muscle tissue morphogenesis", "id": "GO:0055008" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "ventricular septum development", "id": "GO:0003281" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045216", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "id": "A4UGR9", "database": "UniProtKB" } ], "name": "cell-cell junction organization", "id": "GO:0045216" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 109, "annotation": "n_glycosylation_sequon", "start_pos": 107 }, { "end_pos": 269, "annotation": "n_glycosylation_sequon", "start_pos": 267 }, { "end_pos": 377, "annotation": "n_glycosylation_sequon", "start_pos": 375 }, { "end_pos": 418, "annotation": "n_glycosylation_sequon", "start_pos": 416 }, { "end_pos": 774, "annotation": "n_glycosylation_sequon", "start_pos": 772 }, { "end_pos": 806, "annotation": "n_glycosylation_sequon", "start_pos": 804 }, { "end_pos": 1033, "annotation": "n_glycosylation_sequon", "start_pos": 1031 }, { "end_pos": 1190, "annotation": "n_glycosylation_sequon", "start_pos": 1188 }, { "end_pos": 1323, "annotation": "n_glycosylation_sequon", "start_pos": 1321 }, { "end_pos": 1365, "annotation": "n_glycosylation_sequon", "start_pos": 1363 }, { "end_pos": 1461, "annotation": "n_glycosylation_sequon", "start_pos": 1459 }, { "end_pos": 1469, "annotation": "n_glycosylation_sequon", "start_pos": 1467 }, { "end_pos": 1515, "annotation": "n_glycosylation_sequon", "start_pos": 1513 }, { "end_pos": 1593, "annotation": "n_glycosylation_sequon", "start_pos": 1591 }, { "end_pos": 1919, "annotation": "n_glycosylation_sequon", "start_pos": 1917 }, { "end_pos": 2048, "annotation": "n_glycosylation_sequon", "start_pos": 2046 }, { "end_pos": 2085, "annotation": "n_glycosylation_sequon", "start_pos": 2083 }, { "end_pos": 2128, "annotation": "n_glycosylation_sequon", "start_pos": 2126 }, { "end_pos": 2550, "annotation": "n_glycosylation_sequon", "start_pos": 2548 }, { "end_pos": 2673, "annotation": "n_glycosylation_sequon", "start_pos": 2671 }, { "end_pos": 2750, "annotation": "n_glycosylation_sequon", "start_pos": 2748 }, { "end_pos": 2796, "annotation": "n_glycosylation_sequon", "start_pos": 2794 }, { "end_pos": 2996, "annotation": "n_glycosylation_sequon", "start_pos": 2994 }, { "end_pos": 3105, "annotation": "n_glycosylation_sequon", "start_pos": 3103 }, { "end_pos": 3143, "annotation": "n_glycosylation_sequon", "start_pos": 3141 }, { "end_pos": 3210, "annotation": "n_glycosylation_sequon", "start_pos": 3208 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073278.1", "id": "NP_001073278.1", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=14303", "id": "14303", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A4UGR9", "id": "A4UGR9", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A4UGR9", "id": "NX_A4UGR9", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=XIRP2", "id": "XIRP2", "database": "GeneCards" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:129446", "id": "hsa:129446", "database": "KEGG Pathway" }, { "url": "https://www.rcsb.org/structure/4F14", "id": "4F14", "database": "PDB" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163092", "id": "ENSG00000163092", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PPLMMLP/", "id": "PPLMMLP", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030072", "id": "IPR030072", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030107", "id": "IPR030107", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012510", "id": "IPR012510", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF08043", "id": "PF08043", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22591", "id": "PTHR22591", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22591:SF1", "id": "PTHR22591:SF1", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4UGR9", "id": "PR_A4UGR9", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A4UGR9*", "id": "A4UGR9", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/129446", "id": "129446", "database": "GeneID" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4UGR9", "id": "A4UGR9", "database": "BioXpress" } ] } ], "uniprot_ac": "A4UGR9", "disease": [], "mass": { "monoisotopic_mass": 382300.0, "chemical_mass": 382300.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:129446", "id": "hsa:129446", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4UGR9", "name": "XIRP2; CMYA3.", "locus": { "end_pos": 167259753, "start_pos": 166888487, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000163092", "id": "ENSG00000163092", "database": "Ensembl Gene" } ] } } ] }