{
    "uniprot_canonical_ac": "A3KFX0-1", 
    "sequence": {
        "header": "sp|A3KFX0-1|5NT1A_MOUSE Isoform 1 of Cytosolic 5'-nucleotidase 1A  OS=Mus musculus OX=10090 GN=Nt5c1a PE=1 SV=1 CANONICAL=A3KFX0-1", 
        "length": 365, 
        "sequence": "MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ"
    }, 
    "uniprot_id": "5NT1A_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "3.1.3.5", 
            "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate."
        }, 
        {
            "ec": "3.1.3.5", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "cytosolic 5'-nucleotidase 1A", 
                "cytosolic 5' nucleotidase, type 1A; cN-IA; cytosolic 5'-nucleotidase IA"
            ], 
            "uniprotkb": [
                "Cytosolic 5'-nucleotidase 1A", 
                "cN1A", 
                "3.1.3.5", 
                "Cytosolic 5'-nucleotidase IA", 
                "cN-IA"
            ]
        }, 
        "gene": {
            "refseq": [
                "Nt5c1a", 
                "Cn1a", 
                "Gm49"
            ], 
            "uniprotkb": [
                "Nt5c1a", 
                "Cn1a", 
                "Gm49"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                    "id": "A3KFX0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Cytosolic 5'-nucleotidase 1A; cN1A; 3.1.3.5; Cytosolic 5'-nucleotidase IA; cN-IA.", 
        "short": "cN1A"
    }, 
    "publication": [
        {
            "title": "Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28325731", 
            "journal": "American journal of physiology. Endocrinology and metabolism", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
                    "id": "NP_001078971.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kviklyte S, Vertommen D, Yerna X, Andersen H, Xu X, Gailly P, Bohlooly-Y M, Oscarsson J, Rider MH", 
            "date": "2017", 
            "pmid": "28325731"
        }, 
        {
            "title": "Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21873433", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
                    "id": "NP_001078971.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR", 
            "date": "2011", 
            "pmid": "21873433"
        }, 
        {
            "title": "Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15028287", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
                    "id": "NP_001078971.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Onishi M, Yasunaga T, Tanaka H, Nishimune Y, Nozaki M", 
            "date": "2004", 
            "pmid": "15028287"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KFX0#A3KFX0-1", 
            "isoform_ac": "A3KFX0-1", 
            "locus": {
                "end_pos": 123201558, 
                "start_pos": 123216204, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000068262", 
                        "id": "ENSMUST00000068262", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000069422", 
                        "id": "ENSMUSP00000069422", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A3KFX0-1|5NT1A_MOUSE Isoform 1 of Cytosolic 5'-nucleotidase 1A  OS=Mus musculus OX=10090 GN=Nt5c1a PE=1 SV=1 CANONICAL=A3KFX0-1", 
                "length": 365, 
                "sequence": "MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:230718", 
            "resource": "KEGG Pathway", 
            "id": "mmu:230718", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73621", 
            "resource": "Reactome", 
            "id": "R-MMU-73621", 
            "name": "Pyrimidine catabolism"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-74259", 
            "resource": "Reactome", 
            "id": "R-MMU-74259", 
            "name": "Purine catabolism"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KFX0#function", 
            "annotation": "Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3KFX0#function", 
                    "id": "A3KFX0", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
            "annotation": "The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
                    "id": "NP_001078971.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
            "annotation": "NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
                    "id": "NP_001078971.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZVD3-1", 
            "protein_name": "5'-nucleotidase, cytosolic IA; 5'-nucleotidase, cytosolic IA (Predicted).", 
            "sequence": {
                "length": 362, 
                "sequence": "MEPRQPPEAREPGPGAETAAVPRWEEAKTFYDNLSPKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKQLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSKDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRREKQSLGAQ"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/738988/", 
                    "id": "738988", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/57173", 
                    "id": "57173", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9BXI3-1", 
            "protein_name": "Cytosolic 5'-nucleotidase 1A; cN1A; 3.1.3.5; Cytosolic 5'-nucleotidase IA; cN-I; cN-IA.", 
            "sequence": {
                "length": 368, 
                "sequence": "MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/738988/", 
                    "id": "738988", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/57173", 
                    "id": "57173", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
        "ac": "NP_001078971.1", 
        "name": "cytosolic 5'-nucleotidase 1A; cytosolic 5' nucleotidase, type 1A; cN-IA; cytosolic 5'-nucleotidase IA.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "magnesium ion binding", 
                        "id": "GO:0000287"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleotide binding", 
                        "id": "GO:0000166"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008253", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "5'-nucleotidase activity", 
                        "id": "GO:0008253"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009128", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "purine nucleoside monophosphate catabolic process", 
                        "id": "GO:0009128"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009117", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleotide metabolic process", 
                        "id": "GO:0009117"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046085", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KFX0", 
                                "id": "A3KFX0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "adenosine metabolic process", 
                        "id": "GO:0046085"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 35, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 33
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", 
            "id": "NP_001078971.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73621", 
            "id": "R-MMU-73621", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-74259", 
            "id": "R-MMU-74259", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:230718", 
            "id": "mmu:230718", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000054958", 
            "id": "ENSMUSG00000054958", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/QLDHENE/", 
            "id": "QLDHENE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010394", 
            "id": "IPR010394", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF06189", 
            "id": "PF06189", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31367", 
            "id": "PTHR31367", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A3KFX0", 
            "id": "PR_A3KFX0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/230718", 
            "id": "230718", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2155700", 
            "id": "2155700", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A3KFX0", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 40678.0, 
        "chemical_mass": 40678.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KFX0", 
            "name": "Nt5c1a; Cn1a; Gm49.", 
            "locus": {
                "end_pos": 123216275, 
                "start_pos": 123201504, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000054958", 
                        "id": "ENSMUSG00000054958", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}