{ "uniprot_canonical_ac": "A2RU49-1", "sequence": { "header": "sp|A2RU49-1|HYKK_HUMAN Isoform 1 of Hydroxylysine kinase OS=Homo sapiens OX=9606 GN=HYKK PE=1 SV=2 CANONICAL=A2RU49-1", "length": 373, "sequence": "MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECINHGDLNDHNILIESSKSASGNAEYQVSGILDFGDMSYGYYVFEVAITIMYMMIESKSPIQVGGHVLAGFESITPLTAVEKGALFLLVCSRFCQSLVMAAYSCQLYPENKDYLMVTAKTGWKHLQQMFDMGQKAVEEIWFETAKSYESGISM" }, "uniprot_id": "HYKK_HUMAN", "enzyme_annotation": [ { "ec": "2.7.1.81", "activity": "GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine." }, { "ec": "2.7.1.81", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "hydroxylysine kinase isoform 1", "aminoglycoside phosphotransferase domain-containing protein 1; 5-hydroxylysine kinase; 5-hydroxy-L-lysine kinase" ], "uniprotkb": [ "Hydroxylysine kinase", "5-hydroxy-L-lysine kinase", "2.7.1.81", "Aminoglycoside phosphotransferase domain-containing protein 1" ] }, "gene": { "refseq": [ "HYKK", "AGPHD1" ], "uniprotkb": [ "HYKK", "AGPHD1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "id": "A2RU49", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Hydroxylysine kinase; 5-hydroxy-L-lysine kinase; 2.7.1.81; Aminoglycoside phosphotransferase domain-containing protein 1.", "short": "5-hydroxy-L-lysine kinase" }, "publication": [ { "title": "Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27072204", "journal": "Journal of cancer research and therapeutics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Sun H, Pan Y, He B, Deng Q, Ying H, Chen J, Liu X, Wang S", "date": "2016", "pmid": "27072204" }, { "title": "Meta-analysis of the association between the rs8034191 polymorphism in AGPHD1 and lung cancer risk.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25854352", "journal": "Asian Pacific journal of cancer prevention : APJCP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Zhang L, Jin TB, Gao Y, Wang HJ, Yang H, Feng T, Chen C, Kang LL, Chen C", "date": "2015", "pmid": "25854352" }, { "title": "Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25006744", "journal": "American journal of respiratory and critical care medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Castaldi PJ, Cho MH, San Jose Estepar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK", "date": "2014", "pmid": "25006744" }, { "title": "Genetic association between AGPHD1 variant and lung cancer risk.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25074529", "journal": "Cell biochemistry and biophysics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Wang H, Liu ZD", "date": "2014", "pmid": "25074529" }, { "title": "Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22837378", "journal": "American journal of respiratory and critical care medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Soler Artigas M, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH", "date": "2012", "pmid": "22837378" }, { "title": "Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22241472", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "id": "A2RU49", "database": "UniProtKB" } ], "authors": "Veiga-da-Cunha M., Balligand T., Hadi F., Stroobant V., Van Schaftingen E.", "date": "2012", "pmid": "22241472" }, { "title": "A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19300482", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Ruppert A, Lodrup Carlsen KC, Roses A, Anderson W, Rennard SI, Lomas DA, Silverman EK, Goldstein DB", "date": "2009", "pmid": "19300482" }, { "title": "Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18385676", "journal": "Nature genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS", "date": "2008", "pmid": "18385676" }, { "title": "Transcriptome analysis of human gastric cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16341674", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ], "authors": "Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS", "date": "2005", "pmid": "16341674" } ], "glycosylation": [], "mutation": [ { "start_pos": 138, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RU49", "id": "A2RU49", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%). In dbSNP: rs1431042184.", "sequence_org": "P", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "S", "subjects_tested": "103", "end_pos": 138, "type": "Point mutation" }, { "start_pos": 115, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RU49", "id": "A2RU49", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 115, "type": "Point mutation" }, { "start_pos": 278, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RU49", "id": "A2RU49", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%).", "sequence_org": "K", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "Esophageal cancer" }, "sequence_mut": "E", "subjects_tested": "191", "end_pos": 278, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RU49#A2RU49-1", "isoform_ac": "A2RU49-1", "locus": { "end_pos": 78513089, "start_pos": 78533667, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000388988", "id": "ENST00000388988", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000373640", "id": "ENSP00000373640", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RU49-1|HYKK_HUMAN Isoform 1 of Hydroxylysine kinase OS=Homo sapiens OX=9606 GN=HYKK PE=1 SV=2 CANONICAL=A2RU49-1", "length": 373, "sequence": "MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECINHGDLNDHNILIESSKSASGNAEYQVSGILDFGDMSYGYYVFEVAITIMYMMIESKSPIQVGGHVLAGFESITPLTAVEKGALFLLVCSRFCQSLVMAAYSCQLYPENKDYLMVTAKTGWKHLQQMFDMGQKAVEEIWFETAKSYESGISM" } }, { "url": "https://www.uniprot.org/uniprot/A2RU49#A0A0C4DGM4-1", "isoform_ac": "A0A0C4DGM4-1", "locus": { "end_pos": 78513089, "start_pos": 78527580, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000566332", "id": "ENST00000566332", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000457154", "id": "ENSP00000457154", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0C4DGM4-1|HYKK_HUMAN Computationally mapped isoform of Hydroxylysine kinase OS=Homo sapiens OX=9606 GN=HYKK PE=1 SV=1 CANONICAL=A2RU49-1", "length": 226, "sequence": "MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECEYSPN" } }, { "url": "https://www.uniprot.org/uniprot/A2RU49#A2RU49-2", "isoform_ac": "A2RU49-2", "locus": { "end_pos": 78513089, "start_pos": 78518626, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000566289", "id": "ENST00000566289", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000456614", "id": "ENSP00000456614", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RU49-2|HYKK_HUMAN Isoform 2 of Hydroxylysine kinase OS=Homo sapiens OX=9606 GN=HYKK PE=1 SV=2 CANONICAL=A2RU49-1", "length": 172, "sequence": "MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQEGKPRVTPLLAKN" } }, { "url": "https://www.uniprot.org/uniprot/A2RU49#A2RU49-3", "isoform_ac": "A2RU49-3", "locus": { "end_pos": 78513089, "start_pos": 78527563, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000408962", "id": "ENST00000408962", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000386197", "id": "ENSP00000386197", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RU49-3|HYKK_HUMAN Isoform 3 of Hydroxylysine kinase OS=Homo sapiens OX=9606 GN=HYKK PE=1 SV=2 CANONICAL=A2RU49-1", "length": 220, "sequence": "MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:123688", "resource": "KEGG Pathway", "id": "hsa:123688", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71064", "resource": "Reactome", "id": "R-HSA-71064", "name": "Lysine catabolism" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RU49#function", "annotation": "Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49#function", "id": "A2RU49", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "annotation": "CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "annotation": "The association between AGPHD1 single nucleotide polymorphism rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that AGPHD1 single nucleotide polymorphism rs8034191 is a risk factor for lung cancer.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "annotation": "The variant rs8034191 in the AGPHD1 gene may not modify the genetic risk of lung cancer in Asian populations.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZUX1-1", "protein_name": "Similar to RIKEN cDNA C630028N24 gene (Predicted), isoform CRA_b; Hydroxylysine kinase.", "sequence": { "length": 376, "sequence": "MSSGDDQQSQAFTKPTFTEAQASALVESIFGFKVSKIQPLPSYDDQNFHVHISRSQETTDDPVEYVLKISNTKSSQTPDLIEMQNHIIMFLRAAGFPTASVCRTKGDNTISLMSIDSGSEIKSYLVRMLTYLPGRPIAEVATSHQQLYEIGRLAARLDKALEDFHHPKLNLLHRENFIWNLKNVPLLENYMGALSQSRNREIVEQVIQLFKEEVMTKLSHFRECINHGDLNDHNILVDLSKSASGDAVYQVSGILDFGDMSYGYYVFEVAITIMYMMIESTSPIQVGGHVLAGFESVIPLTAVERDALFLLVCARFSQSLVMATYSCQLYPENKEYLMITAKTGWKHLQQMFDMGKKAVEEIWFETAKSYEAGISM" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/773232/", "id": "773232", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/16057", "id": "16057", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5U5V2-1", "protein_name": "Hydroxylysine kinase; 5-hydroxy-L-lysine kinase; 2.7.1.81; Aminoglycoside phosphotransferase domain-containing protein 1.", "sequence": { "length": 376, "sequence": "MSSGAGWQSQASAKPVFTEAQASALVESVFGFKVSKIQPLPSYEDQNFRVHIARGKETTDDPVEYVLKISNTESSQTPELIEMQNHVIMFLRAAGFPTASVCRTKGDNTISLISIDSGSGVKSYLVRMLTYLPGRPIAEVAISHQQLYEIGRLAAQLDKALEEFHHPKLSLFHRENFIWNLKNVPLLEKYMGALSQSRNREIVEQVIRMFKEEVMTKLSHFRECINHGDLNDHNILVDLSKSASGEGVHQVSGILDFGDMSYGYYVFEVAIVIMYMMIESTNPIQVGGHILAGFESVIPLTAVERQALFLLVCSRFSQSLVMAAYSCQLYPENKEYLMITAKTGWKHLQQLFDMGQKAVEEIWFETAKSYESEISM" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/773232/", "id": "773232", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/16057", "id": "16057", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "ac": "NP_001013641.2", "name": "hydroxylysine kinase isoform 1; aminoglycoside phosphotransferase domain-containing protein 1; 5-hydroxylysine kinase; 5-hydroxy-L-lysine kinase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "id": "A2RU49", "database": "UniProtKB" } ], "name": "kinase activity", "id": "GO:0016301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047992", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "id": "A2RU49", "database": "UniProtKB" } ], "name": "hydroxylysine kinase activity", "id": "GO:0047992" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "id": "A2RU49", "database": "UniProtKB" } ], "name": "mitochondrial matrix", "id": "GO:0005759" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006554", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "id": "A2RU49", "database": "UniProtKB" } ], "name": "lysine catabolic process", "id": "GO:0006554" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641.2", "id": "NP_001013641.2", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=34403", "id": "34403", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A2RU49", "id": "A2RU49", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A2RU49", "id": "NX_A2RU49", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=HYKK", "id": "HYKK", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71064", "id": "R-HSA-71064", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:123688", "id": "hsa:123688", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188266", "id": "ENSG00000188266", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/QNFHVHI/", "id": "QNFHVHI", "database": "OMA" }, { "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.81&UniProtAcc=A2RU49", "id": "2.7.1.81", "database": "BRENDA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002575", "id": "IPR002575", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01636", "id": "PF01636", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RU49", "id": "PR_A2RU49", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RU49*", "id": "A2RU49", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/123688", "id": "123688", "database": "GeneID" } ], "expression_disease": [], "uniprot_ac": "A2RU49", "disease": [], "mass": { "monoisotopic_mass": 41933.0, "chemical_mass": 41933.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-71064", "id": "R-HSA-71064", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RU49", "name": "HYKK; AGPHD1.", "locus": { "end_pos": 78537372, "start_pos": 78507564, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000188266", "id": "ENSG00000188266", "database": "Ensembl Gene" } ] } } ] }