{ "uniprot_canonical_ac": "A2AX52-1", "sequence": { "header": "sp|A2AX52-1|CO6A4_MOUSE Isoform 1 of Collagen alpha-4(VI) chain OS=Mus musculus OX=10090 GN=Col6a4 PE=1 SV=2 CANONICAL=A2AX52-1", "length": 2309, "sequence": "MGTWKTFWLIISLAAGLGFVKSQRIVCREASVGDIVFLVHNSINPQHAHSVRNFLYILANSLQVGRDNIRVGLAQYSDTPTSEFLLSVYHRKGDVLKHIRGLQFKPGGNRMGQALQFILEHHFREGAGSRASQGVPQVAVVVSSGLTEDHIREPAEALRRAGILVYAIGVKDASQAELREISSSPKDNFTFFVPNFPGLPGLAQKLRPELCSTLGKAAQYTERESPACSEASPADIVFLVDSSTSIGLQNFQKVKHFLHSVVSGLDVRSDQVQVGLVQYSDNIYPAFPLKQSSLKSAVLDRIRNLPYSMGGTSTGSALEFIRANSLTEMSGSRAKDGVPQIVVLVTDGESSDEVQDVADQLKRDGVFVFVVGINIQDVQELQKIANEPFEEFLFTTENFSILQALSGTLLQALCSTVERQMKKSTKTYADVVFLIDTSQGTSQASFQWMQNFISRIIGILEVGQDKYQIGLAQYSDQGHTEFLFNTHKTRNEMVAHIHELLVFQGGSRKTGQGLRFLHRTFFQEAAGSRLLQGVPQYVVVITSGKSEDEVGEVAQILRKRGVDIVSVGLQDFDRAELEGIGPVVLVSDLQGEDRIRQLMLDVNMFIQGSPKPPRVMTDVAKDAVEECLVPVPADLVFLVEDFSSARQPNFQRVVHFLTTTVHSLNIHPDTTRVSLVFYSEKPRLEFSLDMYQSAAQVLRHLDRLTFRARRGRAKAGAALDFLRKEVFLPEKGSRPHRGVQQIAVVIIESPSLDNVSTPASYLRRAGVTIYAAGTQPASESKDLEKIVTYPPWKHAIRLESFLQLSVVGNKLKKKLCPEMLSGMPPLMSFIPESTRQSTQEGCESVEKADIYFLIDGSGSIKPNDFIEMKDFMKEVIKMFHIGPDRVRFGVVQYSDKIISQFFLTQYASMAGLSAAIDNIQQVGGGTTTGKALSKMVPVFQNTARIDVARYLIVITDGQSTDPVAEAAQGLRDIGVNIYAIGVRDANTTELEEIASKKMFFIYEFDSLKSIHQEVIRDICSSENCKSQKADIIFLIDGSESIAPKDFEKMKDFMERMVNQSNIGADEIQIGLLQFSSNPQEEFRLNRYSSKVDMCRAILSVQQMSDGTHTGKALNFTLPFFDSSRGGRPRVHQYLIVITDGVSQDNVAPPAKALRDRNIIIFAIGVGNVQRAQLLEITNDQDKVFQEENFESLQSLEKEILSEVCSSQGCNIDLSVGVDTSTSSERAQQELRRLLPELMQQLAFLSNISCEAPGQMEPRFRYVVPGSSDQPVFDSGFEKYSDETIQKFLVHQGSVNNRMDVDFLQSLGETAIHLSLAKVKVLLVFTDGLDEDLERLRRTSEFLRSRGLSGLLLIGLGGAHKLEELQELEFGRGFAYRQPLSSSLPSLPSVLLKQLDTIVERTCCNMYAKCYGDDGIRGEPGSRGEQGERGLDGLPGHPGEEGDHGQRGPRGLPGLRGEEGCPGVRGPKGARGFSGEKGNPGEEGVGGLDGEQGDRGAAGPSGEKGSSGSRGLTGLPGPAGPRGEPGLRGDPGDPGIDNLIQGPKGEKGRRGHQGSPGFHGPLGEAGSVGPRGSLGRHGLPGLKGVLGETGELGSRGEPGHPGPQGPRGRQGPPGFFGQKGDPGTQGNPGLPGPSGSKGPDGPRGLKGEVGPAGERGPRGQQGPRGQPGLFGPDGHGYPGRKGRKGEPGFPGYPGVQGEDGNPGRGGEKGAKGIRGKRGNSGFPGLAGTPGDQGPPGKMGTKGSKGLADRTPCEIVDFVRGNCPCSTGISRCPAFPTEVVFTLDMSNDVAPSDFERMRNILLSLLMKLEMCESNCPTGARVAIVSYNTRTDYLVRLSDHRGKAALLQAVRKIPLERSSGSRNLGATMRFVARHVFKRVRSGLLVRKVAVFFQAGRNYDTASVSTATLELHAADIATAVVTFTEEHNLPEAGLVDGPNEFHLFTWETEGQQDVERLASCTLCYDKCRPALGCQLRAPGPQKLDMDLVFLVDSSQGVSRDIYLGALRLVDSVLKDLEVAAQPGTSWHGARAALLTHTTPGFWPGVDQAPVLEYFHLTSHGHRTEMQRQIREAASGLLQGGPALGHALEWTLENVLLTAVLPRRSRVLYAIVASETSIWDREKLRTLSQEAKCKGIALFVLAVGPGVGAQELAELAKVASAPWEQHLLRLEGVSEAEVAYASRFTEAFLNLLNSGINQYPPPELVKECGGPNRGDTLLHFFTSAKRFSRSQSGTSAAFANDSEALKSQGIFLGERKSRVASVALQEALGSHGKDRADTEDIDQETPAKGRHLGPTHGPCPMGPEEGECLNYVLK" }, "uniprot_id": "CO6A4_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "collagen alpha-4(VI) chain precursor", "collagen alpha-4(VI) chain; double von Willebrand factor A domains; dual von Willebrand factor A domains" ], "uniprotkb": [ "Collagen alpha-4(VI) chain" ] }, "gene": { "refseq": [ "Col6a4", "1110001D15Rik", "AI413310", "AU023415", "Dvwa", "EG235580", "Vwa6" ], "uniprotkb": [ "Col6a4", "Dvwa", "1110001D15Rik", "AI413310", "AU023415", "EG235580", "Vwa6" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Collagen alpha-4(VI) chain." }, "publication": [ { "title": "A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26571399", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ], "authors": "Soret R, Mennetrey M, Bergeron KF, Dariel A, Neunlist M, Grunder F, Faure C, Silversides DW, Pilon N", "date": "2015", "pmid": "26571399" }, { "title": "The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22159717", "journal": "Molecular & cellular proteomics : MCP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ], "authors": "Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO", "date": "2012", "pmid": "22159717" }, { "title": "Differential and restricted expression of novel collagen VI chains in mouse.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21477648", "journal": "Matrix biology : journal of the International Society for Matrix Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ], "authors": "Gara SK, Grumati P, Squarzoni S, Sabatelli P, Urciuolo A, Bonaldo P, Paulsson M, Wagener R", "date": "2011", "pmid": "21477648" }, { "title": "Cloning and characterization of the osteoarthritis-associated gene DVWA.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21057832", "journal": "Journal of bone and mineral metabolism", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ], "authors": "Nakajima M, Miyamoto Y, Ikegawa S", "date": "2011", "pmid": "21057832" }, { "title": "Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI).", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18400749", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ], "authors": "Fitzgerald J, Rich C, Zhou FH, Hansen U", "date": "2008", "pmid": "18400749" }, { "title": "Three novel collagen VI chains with high homology to the alpha 3 chain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18276594", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ], "authors": "Koch M., Wagener R., Bonaldo P., Grumati P., Urciuolo A., Paulsson M., Gara S.K., Kobbe B.", "date": "2008", "pmid": "18276594" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52#PTM_processing", "id": "A2AX52", "database": "UniProtKB" } ], "relation": "attached", "position": 1114, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52#PTM_processing", "id": "A2AX52", "database": "UniProtKB" } ], "relation": "attached", "position": 188, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52#PTM_processing", "id": "A2AX52", "database": "UniProtKB" } ], "relation": "attached", "position": 754, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AX52#A2AX52-1", "isoform_ac": "A2AX52-1", "locus": { "end_pos": 105990782, "start_pos": 106082942, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000121963", "id": "ENSMUST00000121963", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000112472", "id": "ENSMUSP00000112472", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AX52-1|CO6A4_MOUSE Isoform 1 of Collagen alpha-4(VI) chain OS=Mus musculus OX=10090 GN=Col6a4 PE=1 SV=2 CANONICAL=A2AX52-1", "length": 2309, "sequence": "MGTWKTFWLIISLAAGLGFVKSQRIVCREASVGDIVFLVHNSINPQHAHSVRNFLYILANSLQVGRDNIRVGLAQYSDTPTSEFLLSVYHRKGDVLKHIRGLQFKPGGNRMGQALQFILEHHFREGAGSRASQGVPQVAVVVSSGLTEDHIREPAEALRRAGILVYAIGVKDASQAELREISSSPKDNFTFFVPNFPGLPGLAQKLRPELCSTLGKAAQYTERESPACSEASPADIVFLVDSSTSIGLQNFQKVKHFLHSVVSGLDVRSDQVQVGLVQYSDNIYPAFPLKQSSLKSAVLDRIRNLPYSMGGTSTGSALEFIRANSLTEMSGSRAKDGVPQIVVLVTDGESSDEVQDVADQLKRDGVFVFVVGINIQDVQELQKIANEPFEEFLFTTENFSILQALSGTLLQALCSTVERQMKKSTKTYADVVFLIDTSQGTSQASFQWMQNFISRIIGILEVGQDKYQIGLAQYSDQGHTEFLFNTHKTRNEMVAHIHELLVFQGGSRKTGQGLRFLHRTFFQEAAGSRLLQGVPQYVVVITSGKSEDEVGEVAQILRKRGVDIVSVGLQDFDRAELEGIGPVVLVSDLQGEDRIRQLMLDVNMFIQGSPKPPRVMTDVAKDAVEECLVPVPADLVFLVEDFSSARQPNFQRVVHFLTTTVHSLNIHPDTTRVSLVFYSEKPRLEFSLDMYQSAAQVLRHLDRLTFRARRGRAKAGAALDFLRKEVFLPEKGSRPHRGVQQIAVVIIESPSLDNVSTPASYLRRAGVTIYAAGTQPASESKDLEKIVTYPPWKHAIRLESFLQLSVVGNKLKKKLCPEMLSGMPPLMSFIPESTRQSTQEGCESVEKADIYFLIDGSGSIKPNDFIEMKDFMKEVIKMFHIGPDRVRFGVVQYSDKIISQFFLTQYASMAGLSAAIDNIQQVGGGTTTGKALSKMVPVFQNTARIDVARYLIVITDGQSTDPVAEAAQGLRDIGVNIYAIGVRDANTTELEEIASKKMFFIYEFDSLKSIHQEVIRDICSSENCKSQKADIIFLIDGSESIAPKDFEKMKDFMERMVNQSNIGADEIQIGLLQFSSNPQEEFRLNRYSSKVDMCRAILSVQQMSDGTHTGKALNFTLPFFDSSRGGRPRVHQYLIVITDGVSQDNVAPPAKALRDRNIIIFAIGVGNVQRAQLLEITNDQDKVFQEENFESLQSLEKEILSEVCSSQGCNIDLSVGVDTSTSSERAQQELRRLLPELMQQLAFLSNISCEAPGQMEPRFRYVVPGSSDQPVFDSGFEKYSDETIQKFLVHQGSVNNRMDVDFLQSLGETAIHLSLAKVKVLLVFTDGLDEDLERLRRTSEFLRSRGLSGLLLIGLGGAHKLEELQELEFGRGFAYRQPLSSSLPSLPSVLLKQLDTIVERTCCNMYAKCYGDDGIRGEPGSRGEQGERGLDGLPGHPGEEGDHGQRGPRGLPGLRGEEGCPGVRGPKGARGFSGEKGNPGEEGVGGLDGEQGDRGAAGPSGEKGSSGSRGLTGLPGPAGPRGEPGLRGDPGDPGIDNLIQGPKGEKGRRGHQGSPGFHGPLGEAGSVGPRGSLGRHGLPGLKGVLGETGELGSRGEPGHPGPQGPRGRQGPPGFFGQKGDPGTQGNPGLPGPSGSKGPDGPRGLKGEVGPAGERGPRGQQGPRGQPGLFGPDGHGYPGRKGRKGEPGFPGYPGVQGEDGNPGRGGEKGAKGIRGKRGNSGFPGLAGTPGDQGPPGKMGTKGSKGLADRTPCEIVDFVRGNCPCSTGISRCPAFPTEVVFTLDMSNDVAPSDFERMRNILLSLLMKLEMCESNCPTGARVAIVSYNTRTDYLVRLSDHRGKAALLQAVRKIPLERSSGSRNLGATMRFVARHVFKRVRSGLLVRKVAVFFQAGRNYDTASVSTATLELHAADIATAVVTFTEEHNLPEAGLVDGPNEFHLFTWETEGQQDVERLASCTLCYDKCRPALGCQLRAPGPQKLDMDLVFLVDSSQGVSRDIYLGALRLVDSVLKDLEVAAQPGTSWHGARAALLTHTTPGFWPGVDQAPVLEYFHLTSHGHRTEMQRQIREAASGLLQGGPALGHALEWTLENVLLTAVLPRRSRVLYAIVASETSIWDREKLRTLSQEAKCKGIALFVLAVGPGVGAQELAELAKVASAPWEQHLLRLEGVSEAEVAYASRFTEAFLNLLNSGINQYPPPELVKECGGPNRGDTLLHFFTSAKRFSRSQSGTSAAFANDSEALKSQGIFLGERKSRVASVALQEALGSHGKDRADTEDIDQETPAKGRHLGPTHGPCPMGPEEGECLNYVLK" } }, { "url": "https://www.uniprot.org/uniprot/A2AX52#A0A1W2P6K8-1", "isoform_ac": "A0A1W2P6K8-1", "locus": { "end_pos": 106000212, "start_pos": 106013446, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000218471", "id": "ENSMUST00000218471", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000151299", "id": "ENSMUSP00000151299", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1W2P6K8-1|CO6A4_MOUSE Computationally mapped isoform of Collagen alpha-4(VI) chain OS=Mus musculus OX=10090 GN=Col6a4 PE=1 SV=1 CANONICAL=A2AX52-1", "length": 134, "sequence": "XKVAVFFQAGRNYDTASVSTATLELHAADIATAVVTFTEEHNLPEAGLVDGPNEFHLFTWETEGQQDVERLASCTLCYDKCRPALGCQLRAPGPQKLDMDLCALGAAPATPRGCLRGRGGLCQQIHGGLPEPSK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:68553", "resource": "KEGG Pathway", "id": "mmu:68553", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AX52#function", "annotation": "Collagen VI acts as a cell-binding protein.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52#function", "id": "A2AX52", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "annotation": "The collagen VI alpha 4 chain is strongly expressed in the intestinal smooth muscle, surrounding the follicles in ovary, and in testis", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "annotation": "DVWA is evolutionally very unique, which, together with its specific expression in articular cartilage, suggests its specific role in human cartilage metabolism.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "annotation": "Discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "annotation": "Analysis of collagen VI chains alpha4, alpha5, and alpha6with high homology to the alpha3 chain", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M6H4-1", "protein_name": "Collagen, type VI, alpha 4.", "sequence": { "length": 2113, "sequence": "MGTWKTLWLIISFAAGLGFIKSQRTVCREASVGDIVFLVHTNIDPQHAQSVRNFLYILANSLQVGGDNIRVSLALYGDTPTTEFLLSAYPRKGDVLKHIRGLQFKPGGNRMGQSLQFILEHHFPEGAGSRASQGVPQVALVMSTGVAEDHFREPAEALKREGILLYAIGVKDAAQAELREIASSPKDNFTFFVPNFSGLPGLAQKLRPELCTTLAKVVQHTEQGSPACTEAFLADIVFLVDSSTSIGLQNFQKVKNFLHSIVSGLDVRSDQVQVGLVQYSDNIYPAFQLKQSSLKSVVLEQIRNLPYNMGSTNTGSALEFIRANYLTEMSGSRAKDGVPQIVILVTDGESNDEVQDAADQLKRDGVFVYVVGINIQDVQELQKIASEPFEEFLFTTENFNILQELSGSLSQAVCSTVEREMKKCLAPIPTDLVFLVEEFTSAGQPNFQQVIKLLKTTVHSLNIHPDIVRVSLVFYSEKPQLKFSLNTFQNAAQVLTSLDQLTFRARRGRTKAGAALDFLRKEVFLPEKGSRSIWGVQQIAVIIMESPSLDNVSTPASHLRRTGVTIYAVGIQSASESKDLEKIATYPPGKHTIHLESFLQLDVVRKILNKKLCPETLGKMPPVGSMPPGAEMPPGAEMPPGGKMPPLTGCTPQSMQKVCTHVEKADIYFLIDGSGSISPKDFTEMKEFMKDVIKMFHIGPDGVRFGVVQYSDKIISQFLLTQYTSMEKLGTAIGNIQQGGGGTTTGELSKMALVFRNTARTNVAQYLIVITDGQSSDPVADAAQGLRDTGINIYAIGVRDANTTELEEIANNRVFFTDDFHFLKSIHQEVVRDICSFENCRSQKADIIFLIDGSESISSEDFEKIKDFVKRMVNQSNIGADKIQIGLLQFSSTPREEFTLKNNYSSKDEMCRAISNVTQINSGTETGKALNFTLPFFDISQGGRPGVHQYLIVITDGDSHDDIVSPAKALRDRNIIIFAIGVGKIQRAQLLAITNDQDKVYHEENFESLQNLEKEILYEVCTSQGCSMDLSVGVDTSTSSGRAQQELGRFLPGLLQQLALLSNISCEAPGQMEPRFRYVVPGSSSRPVFDSGFEKYNDETVQKFLVQQGSANNRLNVDFLKSLGETAIHSSSANVKVLLVFTDGLDEDLERLRRTSELLRSGGLSGLLVIGLGGAHKLEELQELEFGKGFAYRQPLSSSLPSLPSVLLKQLDTIVEKACCYVCAKCYGDDGVRGDPGSLGKEGERGLDGLPGHPGEDGDHGPRGPRGLPGLRGEEGCPGVRGPKGARGFSGEKGNPGDEGVEGLDGEQGDRGAAGSSGEKGSRGSQGLTGLPGPAGSRGEPGLRGDPGDPGIDNFIQGPKGEKGRRGRQGSSGFHGLLGETGSVGPWGSLGRRGLPGLKGVLGEAGELGYQGEPGYPGPQGPRGRQGPPGSFGQKGDAGAQGNPGPPGPNGSRGTDGPRGLKGELGHTGERGPRGQQGSRGQPGRFGLDGYGHPGRKGKKGEPGFPGYPGLQGEDGNPGRGGEKGAKGIRGKRGSSGFPGFAGTPGDQGPPGKMGIKGPKGLADRTPCEIVDFVRGNCPPCQGISRCPAFPTEVVFALDMSNDVSQSDFERMRNILLSLLMKLEMSESNCPTGARVAIVSYNMRTDYLVRLSDHRGKATLLQAVRKIPLERSSGFRNLGATMKFVARHVFKRVRSGFLVRKVAVFFQVGGNYDATSVNTAMLELHAANIVTAVVTFTEDHNLPDALLVDGLNTFHLFTWETEHQQDVERLVSCTLCYDKCRPAPGCRVESPRPQELDMDLVFLVDSSQGVSRDIYLGALRLVDSVLKDLEVAAQPGTSWHGARVALLTHTTPGFWPGVGQDPVLEYFHLTSHGHRTQMQRQIQEAASGLLQGAPALGHALEWTLEKVLLAAILPRRSQVLFAIVASETSIWDRETLRALSLEAKCKGITLFVLAVGPGVGAQELTELANVASAPSEQHLLRLEGVSEAEVAYASRFTEAFLNLLKSGINQYPPPELNEECGGPNRGDTLLQFFTSAKRLSKPRFGTSAATGYDSGAPKPQDSFLRGKRKIRTLSVAQQETLGSLGRDRADAEETPAKGRRSGAAHGEIPNLVL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/804106/", "id": "804106", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "ac": "NP_081039.2", "name": "collagen alpha-4(VI) chain precursor; collagen alpha-4(VI) chain; double von Willebrand factor A domains; dual von Willebrand factor A domains.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "collagen binding", "id": "GO:0005518" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "extracellular region", "id": "GO:0005576" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "extracellular matrix", "id": "GO:0031012" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "collagen-containing extracellular matrix", "id": "GO:0062023" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005581", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "collagen trimer", "id": "GO:0005581" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "extracellular matrix organization", "id": "GO:0030198" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52", "database": "UniProtKB" } ], "name": "cell adhesion", "id": "GO:0007155" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 190, "annotation": "n_glycosylation_sequon", "start_pos": 188 }, { "end_pos": 400, "annotation": "n_glycosylation_sequon", "start_pos": 398 }, { "end_pos": 756, "annotation": "n_glycosylation_sequon", "start_pos": 754 }, { "end_pos": 988, "annotation": "n_glycosylation_sequon", "start_pos": 986 }, { "end_pos": 1060, "annotation": "n_glycosylation_sequon", "start_pos": 1058 }, { "end_pos": 1116, "annotation": "n_glycosylation_sequon", "start_pos": 1114 }, { "end_pos": 1248, "annotation": "n_glycosylation_sequon", "start_pos": 1246 }, { "end_pos": 2237, "annotation": "n_glycosylation_sequon", "start_pos": 2235 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039.2", "id": "NP_081039.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:68553", "id": "mmu:68553", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032572", "id": "ENSMUSG00000032572", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/VHQYLIV/", "id": "VHQYLIV", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "id": "IPR002035", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "id": "IPR036465", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "id": "IPR008160", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00092", "id": "PF00092", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01391", "id": "PF01391", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AX52", "id": "PR_A2AX52", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/68553", "id": "68553", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1915803", "id": "1915803", "database": "MGI" }, { "url": "https://acgg.asia/gpdb2/GPDB0001740", "id": "GPDB0001740", "database": "GlycoProtDB" } ], "expression_disease": [], "uniprot_ac": "A2AX52", "disease": [], "mass": { "monoisotopic_mass": 250798.0, "chemical_mass": 250798.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AX52", "name": "Col6a4; Dvwa; 1110001D15Rik; AI413310; AU023415; EG235580; Vwa6.", "locus": { "end_pos": 105989454, "start_pos": 106096783, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000032572", "id": "ENSMUSG00000032572", "database": "Ensembl Gene" } ] } } ] }