{ "uniprot_canonical_ac": "A2AWT3-1", "sequence": { "header": "sp|A2AWT3-1|AT7L3_MOUSE Isoform 1 of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1", "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" }, "uniprot_id": "AT7L3_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "ataxin-7-like protein 3 isoform a", "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog" ], "uniprotkb": [ "Ataxin-7-like protein 3", "SAGA-associated factor 11 homolog" ] }, "gene": { "refseq": [ "Atxn7l3", "E030022H21Rik" ], "uniprotkb": [ "Atxn7l3", "E030022H21Rik" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog." }, "publication": [ { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306.1", "id": "NP_001092306.1", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25228644", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306.1", "id": "NP_001092306.1", "database": "RefSeq" } ], "authors": "Bonnet J, Wang CY, Baptista T, Vincent SD, Hsiao WC, Stierle M, Kao CF, Tora L, Devys D", "date": "2014", "pmid": "25228644" }, { "title": "Genomic analysis of mouse retinal development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15226823", "journal": "PLoS biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306.1", "id": "NP_001092306.1", "database": "RefSeq" } ], "authors": "Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL", "date": "2004", "pmid": "15226823" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3#A2AWT3-1", "isoform_ac": "A2AWT3-1", "locus": { "end_pos": 102291658, "start_pos": 102294999, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107134", "id": "ENSMUST00000107134", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102752", "id": "ENSMUSP00000102752", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWT3-1|AT7L3_MOUSE Isoform 1 of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1", "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } }, { "url": "https://www.uniprot.org/uniprot/A2AWT3#F6RCN9-1", "isoform_ac": "F6RCN9-1", "locus": { "end_pos": 102291656, "start_pos": 102294163, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000141516", "id": "ENSMUST00000141516", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121917", "id": "ENSMUSP00000121917", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6RCN9-1|AT7L3_MOUSE Computationally mapped isoform of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1", "length": 258, "sequence": "XRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGFSVCTSASNTLPLLFSSSGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } }, { "url": "https://www.uniprot.org/uniprot/A2AWT3#A2AWT3-2", "isoform_ac": "A2AWT3-2", "locus": { "end_pos": 102291658, "start_pos": 102294999, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107132", "id": "ENSMUST00000107132", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102750", "id": "ENSMUSP00000102750", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWT3-2|AT7L3_MOUSE Isoform 2 of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1", "length": 354, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } }, { "url": "https://www.uniprot.org/uniprot/A2AWT3#Z4YN62-1", "isoform_ac": "Z4YN62-1", "locus": { "end_pos": 102291658, "start_pos": 102294987, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000137387", "id": "ENSMUST00000137387", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122610", "id": "ENSMUSP00000122610", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YN62-1|AT7L3_MOUSE Computationally mapped isoform of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1", "length": 350, "sequence": "EMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:217218", "resource": "KEGG Pathway", "id": "mmu:217218", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3#function", "annotation": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3#function", "id": "A2AWT3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q14CW9-1", "protein_name": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog.", "sequence": { "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/35401", "id": "35401", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4A5H7-1", "protein_name": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog.", "sequence": { "length": 347, "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALLSRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPAPSIYEDIN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/35401", "id": "35401", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306.1", "ac": "NP_001092306.1", "name": "ataxin-7-like protein 3 isoform a; Ataxin-7-like protein 3; SAGA-associated factor 11 homolog.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "transcription coactivator activity", "id": "GO:0003713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030374", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "nuclear receptor transcription coactivator activity", "id": "GO:0030374" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071819", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "DUBm complex", "id": "GO:0071819" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "SAGA complex", "id": "GO:0000124" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016578", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "histone deubiquitination", "id": "GO:0016578" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010390", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3", "database": "UniProtKB" } ], "name": "histone monoubiquitination", "id": "GO:0010390" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 90, "annotation": "n_glycosylation_sequon", "start_pos": 88 }, { "end_pos": 113, "annotation": "n_glycosylation_sequon", "start_pos": 111 }, { "end_pos": 129, "annotation": "n_glycosylation_sequon", "start_pos": 127 }, { "end_pos": 189, "annotation": "n_glycosylation_sequon", "start_pos": 187 }, { "end_pos": 303, "annotation": "n_glycosylation_sequon", "start_pos": 301 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306.1", "id": "NP_001092306.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:217218", "id": "mmu:217218", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000059995", "id": "ENSMUSG00000059995", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013243", "id": "IPR013243", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013246", "id": "IPR013246", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF08313", "id": "PF08313", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08209", "id": "PF08209", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AWT3", "id": "PR_A2AWT3", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AWT3*", "id": "A2AWT3", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/217218", "id": "217218", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3036270", "id": "3036270", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AWT3", "disease": [], "mass": { "monoisotopic_mass": 38594.0, "chemical_mass": 38594.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AWT3", "name": "Atxn7l3; E030022H21Rik.", "locus": { "end_pos": 102289300, "start_pos": 102296631, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000059995", "id": "ENSMUSG00000059995", "database": "Ensembl Gene" } ] } } ] }