{
    "uniprot_canonical_ac": "A2AS55-1", 
    "sequence": {
        "header": "sp|A2AS55-1|ANR16_MOUSE Isoform 1 of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=1 CANONICAL=A2AS55-1", 
        "length": 361, 
        "sequence": "MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGTLAQQLTRSVDILQDFDHDVKS"
    }, 
    "uniprot_id": "ANR16_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "ankyrin repeat domain-containing protein 16 isoform 1", 
                "ankyrin repeat domain-containing protein 16"
            ], 
            "uniprotkb": [
                "Ankyrin repeat domain-containing protein 16"
            ]
        }, 
        "gene": {
            "refseq": [
                "Ankrd16", 
                "2810455F06Rik", 
                "AI646698", 
                "D430029B21Rik"
            ], 
            "uniprotkb": [
                "Ankrd16", 
                "2810455F06Rik", 
                "AI646698", 
                "D430029B21Rik"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS55", 
                    "id": "A2AS55", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Ankyrin repeat domain-containing protein 16."
    }, 
    "publication": [
        {
            "title": "ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/29769718", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS55", 
                    "id": "A2AS55", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796242.2", 
                    "id": "NP_796242.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Moresco J.J., Sun L., Yates J.R. III, Fu H., Liu Q., Schimmel P., Roy B., Lee J.W., Terrey M., Ackerman S.L., Vo M.N., Fredrick K., Weber T.G.", 
            "date": "2018", 
            "pmid": "29769718"
        }, 
        {
            "title": "Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21510876", 
            "journal": "BMC genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796242.2", 
                    "id": "NP_796242.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri K, Tak J, Chung ED, Mastromonaco G, Caniggia I, Varmuza S", 
            "date": "2011", 
            "pmid": "21510876"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#A2AS55-1", 
            "isoform_ac": "A2AS55-1", 
            "locus": {
                "end_pos": 11778589, 
                "start_pos": 11789888, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000056108", 
                        "id": "ENSMUST00000056108", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000052056", 
                        "id": "ENSMUSP00000052056", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AS55-1|ANR16_MOUSE Isoform 1 of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=1 CANONICAL=A2AS55-1", 
                "length": 361, 
                "sequence": "MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGTLAQQLTRSVDILQDFDHDVKS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#F6T2W3-1", 
            "isoform_ac": "F6T2W3-1", 
            "locus": {
                "end_pos": 11784293, 
                "start_pos": 11785237, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000128774", 
                        "id": "ENSMUST00000128774", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000121218", 
                        "id": "ENSMUSP00000121218", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F6T2W3-1|ANR16_MOUSE Computationally mapped isoform of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=2 CANONICAL=A2AS55-1", 
                "length": 76, 
                "sequence": "XCSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKLQRICGVTPFMDTLQFSHVCIA"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#A2AS55-2", 
            "isoform_ac": "A2AS55-2", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "N/A", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A2AS55-2|ANR16_MOUSE Isoform 2 of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=1 CANONICAL=A2AS55-1", 
                "length": 187, 
                "sequence": "MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIRRTPLHTAGTPCKLWSL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#D6RGL4-1", 
            "isoform_ac": "D6RGL4-1", 
            "locus": {
                "end_pos": 11778589, 
                "start_pos": 11781513, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000156067", 
                        "id": "ENSMUST00000156067", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115525", 
                        "id": "ENSMUSP00000115525", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|D6RGL4-1|ANR16_MOUSE Computationally mapped isoform of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=1 CANONICAL=A2AS55-1", 
                "length": 166, 
                "sequence": "MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRNARLFGSSPGAS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#A0A0A6YWT3-1", 
            "isoform_ac": "A0A0A6YWT3-1", 
            "locus": {
                "end_pos": 11778589, 
                "start_pos": 11778858, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000130186", 
                        "id": "ENSMUST00000130186", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000141685", 
                        "id": "ENSMUSP00000141685", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0A6YWT3-1|ANR16_MOUSE Computationally mapped isoform of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=1 CANONICAL=A2AS55-1", 
                "length": 90, 
                "sequence": "MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#F6SD06-1", 
            "isoform_ac": "F6SD06-1", 
            "locus": {
                "end_pos": 11779885, 
                "start_pos": 11783752, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000133664", 
                        "id": "ENSMUST00000133664", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115226", 
                        "id": "ENSMUSP00000115226", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F6SD06-1|ANR16_MOUSE Computationally mapped isoform of Ankyrin repeat domain-containing protein 16  OS=Mus musculus OX=10090 GN=Ankrd16 PE=1 SV=2 CANONICAL=A2AS55-1", 
                "length": 56, 
                "sequence": "LHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:320816", 
            "resource": "KEGG Pathway", 
            "id": "mmu:320816", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55#function", 
            "annotation": "Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity (PubMed:29769718). Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides (PubMed:29769718).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AS55#function", 
                    "id": "A2AS55", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796242.2", 
            "annotation": "Results identify an amino-acid-accepting co-regulator of tRNA synthetase editing, ANKRD16, as a new layer of the machinery that is essential to the prevention of severe pathologies that arise from defects in editing Erratum:[Nature. 2018 Aug;560(7720):E35. PMID: 29925958]", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796242.2", 
                    "id": "NP_796242.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6P6B7-1", 
            "protein_name": "Ankyrin repeat domain-containing protein 16.", 
            "sequence": {
                "length": 361, 
                "sequence": "MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAMT"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/19509", 
                    "id": "19509", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q499M5-1", 
            "protein_name": "Ankyrin repeat domain-containing protein 16.", 
            "sequence": {
                "length": 370, 
                "sequence": "MAPPGDPRRLCRLVQEGQLRALREELEVAGGCWDPEMFRGSQGPAGDTLLHFASRHGRQDILAYLVEAWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDVWKTESKIRRTPLHTAAMHGCFEAVQELLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLENHEACSSATDSLGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALLYAAKEGQTSTVQTLLSLGADINSTDERNRSALHLACAGQHAACARFLRQSGLKDSADLTGALAQQLTRGVAILQDFDPGVKS"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/549775/", 
                    "id": "549775", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/19509", 
                    "id": "19509", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796242.2", 
        "ac": "NP_796242.2", 
        "name": "ankyrin repeat domain-containing protein 16 isoform 1; ankyrin repeat domain-containing protein 16.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS55", 
                                "id": "A2AS55", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS55", 
                                "id": "A2AS55", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AS55", 
                                "id": "A2AS55", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tRNA modification", 
                        "id": "GO:0006400"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 303, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 301
        }, 
        {
            "end_pos": 309, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 307
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796242.2", 
            "id": "NP_796242.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:320816", 
            "id": "mmu:320816", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000047909", 
            "id": "ENSMUSG00000047909", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/WNCFHIA/", 
            "id": "WNCFHIA", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", 
            "id": "IPR002110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", 
            "id": "IPR020683", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", 
            "id": "IPR036770", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00023", 
            "id": "PF00023", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF12796", 
            "id": "PF12796", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AS55", 
            "id": "PR_A2AS55", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/320816", 
            "id": "320816", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2444796", 
            "id": "2444796", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2AS55", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 39776.0, 
        "chemical_mass": 39776.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AS55", 
            "name": "Ankrd16; 2810455F06Rik; AI646698; D430029B21Rik.", 
            "locus": {
                "end_pos": 11790329, 
                "start_pos": 11777876, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000047909", 
                        "id": "ENSMUSG00000047909", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}