{ "uniprot_canonical_ac": "A2APX8-1", "sequence": { "header": "sp|A2APX8-1|SCN1A_MOUSE Isoform 1 of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1 CANONICAL=A2APX8-1", "length": 2009, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGIAYVKRKIYEFIQQSFVKKQKILDEIKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKEDMLIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK" }, "uniprot_id": "SCN1A_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "sodium channel protein type 1 subunit alpha isoform 1", "sodium channel protein type I subunit alpha; sodium channel protein brain I subunit alpha; voltage-gated sodium channel subunit alpha Nav1.1; sodium channel protein type 1 subunit alpha" ], "uniprotkb": [ "Sodium channel protein type 1 subunit alpha", "Sodium channel protein type I subunit alpha", "Sodium channel protein brain I subunit alpha", "Voltage-gated sodium channel subunit alpha Nav1.1" ] }, "gene": { "refseq": [ "Scn1a", "B230332M13", "Nav1.1" ], "uniprotkb": [ "Scn1a", "B230332M13", "Nav1.1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Sodium channel protein type 1 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein brain I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1." }, "publication": [ { "title": "Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/31047779", "journal": "Neuron", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "id": "NP_001300926.1", "database": "RefSeq" } ], "authors": "Styr B, Gonen N, Zarhin D, Ruggiero A, Atsmon R, Gazit N, Braun G, Frere S, Vertkin I, Shapira I, Harel M, Heim LR, Katsenelson M, Rechnitz O, Fadila S, Derdikman D, Rubinstein M, Geiger T, Ruppin E, Slutsky I", "date": "2019", "pmid": "31047779" }, { "title": "Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30996233", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "id": "NP_001300926.1", "database": "RefSeq" } ], "authors": "Yuan Y, O'Malley HA, Smaldino MA, Bouza AA, Hull JM, Isom LL", "date": "2019", "pmid": "30996233" }, { "title": "Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/31282864", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "id": "NP_001300926.1", "database": "RefSeq" } ], "authors": "Goff KM, Goldberg EM", "date": "2019", "pmid": "31282864" }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "journal": "Nature communications", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2718", "id": "2718", "database": "GlyConnect" } ], "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "date": "2019", "pmid": "30899004" }, { "title": "Scn1a dysfunction alters behavior but not the effect of stress on seizure response.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26694226", "journal": "Genes Brain Behav.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Escayg A., Neigh G.N., Decker M.J., Helvig A.W., Makinson C.D., Sawyer N.T.", "date": "2016", "pmid": "26694226" }, { "title": "Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27281198", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Wang X., Zhang C., Castro J., King G.F., Gilchrist J., Basbaum A.I., Alewood P., Bosmans F., Julius D., Brierley S.M., Stucky C.L., Weyer A.D., Dekan Z., Emrick J.J., Garcia-Caraballo S., Grundy L., Herzig V., Osteen J.D., Rychkov G.Y., Undheim E.A.", "date": "2016", "pmid": "27281198" }, { "title": "Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22908258", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Catterall W.A., Westenbroek R.E., Yu F.H., Rubenstein J.L., Cheah C.S., Kalume F.K., Oakley J.C., Potter G.B.", "date": "2012", "pmid": "22908258" }, { "title": "Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22914087", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Han S., Catterall W.A., Scheuer T., Westenbroek R.E., Yu F.H., Rubenstein J.L., Cheah C.S., Potter G.B., Tai C., de la Iglesia H.O.", "date": "2012", "pmid": "22914087" }, { "title": "Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20100831", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Meisler M.H., Escayg A., Shankar A., Goldin A.L., de Haan G., Baram T.Z., Dube C.M., Dutt K., Dutton S.B., Martin M.S., Papale L.A., Tufik S.", "date": "2010", "pmid": "20100831" }, { "title": "Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17928448", "journal": "J. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Catterall W.A., Scheuer T., Westenbroek R.E., Yu F.H., Kalume F.", "date": "2007", "pmid": "17928448" }, { "title": "Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16921370", "journal": "Nat. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Catterall W.A., Scheuer T., Westenbroek R.E., McKnight G.S., Burton K.A., Mantegazza M., Yu F.H., Robbins C.A., Kalume F., Spain W.J.", "date": "2006", "pmid": "16921370" }, { "title": "Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15746173", "journal": "J. Physiol. (Lond.)", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "authors": "Camacho J.A., Benndorf K., Dumaine R., Guenther B., Haufe V., Zimmer T., Bollensdorff C., von Banchet G.S.", "date": "2005", "pmid": "15746173" }, { "title": "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8062593", "journal": "Cytogenetics and cell genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "id": "NP_001300926.1", "database": "RefSeq" } ], "authors": "Malo MS, Blanchard BJ, Andresen JM, Srivastava K, Chen XN, Li X, Jabs EW, Korenberg JR, Ingram VM", "date": "1994", "pmid": "8062593" }, { "title": "Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8169823", "journal": "The Journal of pharmacology and experimental therapeutics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "id": "NP_001300926.1", "database": "RefSeq" } ], "authors": "Crabbe JC, Belknap JK, Mitchell SR, Crawshaw LI", "date": "1994", "pmid": "8169823" }, { "title": "Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/1679748", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "id": "NP_001300926.1", "database": "RefSeq" } ], "authors": "Malo D, Schurr E, Dorfman J, Canfield V, Levenson R, Gros P", "date": "1991", "pmid": "1679748" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#PTM_processing", "id": "A2APX8", "database": "UniProtKB" } ], "relation": "attached", "position": 301, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#PTM_processing", "id": "A2APX8", "database": "UniProtKB" } ], "relation": "attached", "position": 306, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#PTM_processing", "id": "A2APX8", "database": "UniProtKB" } ], "relation": "attached", "position": 295, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#PTM_processing", "id": "A2APX8", "database": "UniProtKB" } ], "relation": "attached", "position": 338, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#A2APX8-1", "isoform_ac": "A2APX8-1", "locus": { "end_pos": 66272888, "start_pos": 66351177, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112366", "id": "ENSMUST00000112366", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107985", "id": "ENSMUSP00000107985", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APX8-1|SCN1A_MOUSE Isoform 1 of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1 CANONICAL=A2APX8-1", "length": 2009, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGIAYVKRKIYEFIQQSFVKKQKILDEIKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKEDMLIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK" } }, { "url": "https://www.uniprot.org/uniprot/A2APX8#A0A0J9YVF2-1", "isoform_ac": "A0A0J9YVF2-1", "locus": { "end_pos": 66274045, "start_pos": 66318139, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000156865", "id": "ENSMUST00000156865", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000144633", "id": "ENSMUSP00000144633", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YVF2-1|SCN1A_MOUSE Computationally mapped isoform of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1 CANONICAL=A2APX8-1", "length": 502, "sequence": "EFIQQSFVKKQKILDEIKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGGCFLRS" } }, { "url": "https://www.uniprot.org/uniprot/A2APX8#A2APX8-2", "isoform_ac": "A2APX8-2", "locus": { "end_pos": 66272888, "start_pos": 66351177, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112371", "id": "ENSMUST00000112371", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107990", "id": "ENSMUSP00000107990", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APX8-2|SCN1A_MOUSE Isoform 2 of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1 CANONICAL=A2APX8-1", "length": 1998, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGIAYVKRKIYEFIQQSFVKKQKILDEIKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKEDMLIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK" } }, { "url": "https://www.uniprot.org/uniprot/A2APX8#A2APX9-1", "isoform_ac": "A2APX9-1", "locus": { "end_pos": 66326064, "start_pos": 66351177, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000138910", "id": "ENSMUST00000138910", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000116881", "id": "ENSMUSP00000116881", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2APX9-1|SCN1A_MOUSE Computationally mapped isoform of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=6 CANONICAL=A2APX8-1", "length": 500, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNR" } }, { "url": "https://www.uniprot.org/uniprot/A2APX8#A2APX8-3", "isoform_ac": "A2APX8-3", "locus": { "end_pos": 66272888, "start_pos": 66351177, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000094951", "id": "ENSMUST00000094951", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000092558", "id": "ENSMUSP00000092558", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APX8-3|SCN1A_MOUSE Isoform 3 of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1 CANONICAL=A2APX8-1", "length": 1981, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGIAYVKRKIYEFIQQSFVKKQKILDEIKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKEDMLIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK" } }, { "url": "https://www.uniprot.org/uniprot/A2APX8#A0A0J9YUJ5-1", "isoform_ac": "A0A0J9YUJ5-1", "locus": { "end_pos": 66289027, "start_pos": 66317946, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000200839", "id": "ENSMUST00000200839", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000144214", "id": "ENSMUSP00000144214", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YUJ5-1|SCN1A_MOUSE Computationally mapped isoform of Sodium channel protein type 1 subunit alpha OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1 CANONICAL=A2APX8-1", "length": 303, "sequence": "XIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRDNLAPTWMGWSGGSSPQPFIMGGCECPVRSNSIHHECASGLPYILANFQHHGRKFVCWQILPLC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:20265", "resource": "KEGG Pathway", "id": "mmu:20265", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5576892", "resource": "Reactome", "id": "R-MMU-5576892", "name": "Phase 0 - rapid depolarisation" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#function", "annotation": "Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8#function", "id": "A2APX8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P04774-1", "protein_name": "Sodium channel protein type 1 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein brain I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1.", "sequence": { "length": 2009, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNVTTDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAAATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAGLPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIRNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFVRKQKILDEIKPLDDLNNRKDNCTSNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVMEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDTFEITEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/21375", "id": "21375", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "P35498-1", "protein_name": "Sodium channel protein type 1 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein brain I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1.", "sequence": { "length": 2009, "sequence": "MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/21375", "id": "21375", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926.1", "ac": "NP_001300926.1", "name": "sodium channel protein type 1 subunit alpha isoform 1; sodium channel protein type I subunit alpha; sodium channel protein brain I subunit alpha; voltage-gated sodium channel subunit alpha Nav1.1; sodium channel protein type 1 subunit alpha.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005248", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "voltage-gated sodium channel activity", "id": "GO:0005248" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005244", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "voltage-gated ion channel activity", "id": "GO:0005244" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031402", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "sodium ion binding", "id": "GO:0031402" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014704", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "intercalated disc", "id": "GO:0014704" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "Z disc", "id": "GO:0030018" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030315", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "T-tubule", "id": "GO:0030315" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033268", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "node of Ranvier", "id": "GO:0033268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043194", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "axon initial segment", "id": "GO:0043194" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034706", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APX8", "id": "A2APX8", "database": "UniProtKB" } ], "name": "sodium channel complex", "id": "GO:0034706" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 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