{ "uniprot_canonical_ac": "A2AH22-1", "sequence": { "header": "sp|A2AH22-1|AMRA1_MOUSE Isoform 1 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1300, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" }, "uniprot_id": "AMRA1_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "activating molecule in BECN1-regulated autophagy protein 1 isoform 2", "activating molecule in BECN1-regulated autophagy protein 1; activating molecule in Beclin1-regulated autophagy" ], "uniprotkb": [ "Activating molecule in BECN1-regulated autophagy protein 1" ] }, "gene": { "refseq": [ "Ambra1", "2310079H06Rik", "A130023A14", "AA474864", "AV021921", "D030051N19Rik", "mKIAA1736" ], "uniprotkb": [ "Ambra1", "Kiaa1736", "2310079H06Rik", "A130023A14", "AA474864", "AV021921", "D030051N19Rik", "mKIAA1736" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Activating molecule in BECN1-regulated autophagy protein 1." }, "publication": [ { "title": "Mitsugumin 53 promotes mitochondrial autophagy through regulating Ambra1 expression in C2C12 myoblast cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30614598", "journal": "Cell biology international", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Lijie G, Yueyue Z, Nan Z, Ling W, Xuan W, Weijie Y", "date": "2019", "pmid": "30614598" }, { "title": "Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30532260", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Coccurello R, Nazio F, Rossi C, De Angelis F, Vacca V, Giacovazzo G, Procacci P, Magnaghi V, Ciavardelli D, Marinelli S", "date": "2018", "pmid": "30532260" }, { "title": "Ambra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29488136", "journal": "Molecular neurobiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Nobili A, Krashia P, Cordella A, La Barbera L, Dell'Acqua MC, Caruso A, Pignataro A, Marino R, Sciarra F, Biamonte F, Scattoni ML, Ammassari-Teule M, Cecconi F, Berretta N, Keller F, Mercuri NB, D'Amelio M", "date": "2018", "pmid": "29488136" }, { "title": "Sexual dimorphism of AMBRA1-related autistic features in human and mouse.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28994820", "journal": "Translational psychiatry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Mitjans M, Begemann M, Ju A, Dere E, Wustefeld L, Hofer S, Hassouna I, Balkenhol J, Oliveira B, van der Auwera S, Tammer R, Hammerschmidt K, Volzke H, Homuth G, Cecconi F, Chowdhury K, Grabe H, Frahm J, Boretius S, Dandekar T, Ehrenreich H", "date": "2017", "pmid": "28994820" }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014", "pmid": "24129315" }, { "title": "Functional interaction between autophagy and ciliogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24089209", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "authors": "Codogno P., Patel B., Beau I., Cuervo A.M., Diaz-Carretero A., Orhon I., Pampliega O., Satir B.H., Satir P., Sridhar S.", "date": "2013", "pmid": "24089209" }, { "title": "Parkin interacts with Ambra1 to induce mitophagy.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21753002", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W", "date": "2011", "pmid": "21753002" }, { "title": "Ambra1 regulates autophagy and development of the nervous system.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17589504", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Cecconi F., Piacentini M., Chowdhury K., Corazzari M., Di Bartolomeo S., Fuoco C., Giunta L., Gruss P., Maria Fimia G., Nardacci R., Romagnoli A., Schwartz P., Stoykova A., Ucar A.", "date": "2007", "pmid": "17589504" }, { "title": "Autophagy: a new regulator of development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17603510", "journal": "Nat. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "authors": "Le Bot N.", "date": "2007", "pmid": "17603510" }, { "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003", "pmid": "12520002" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-1", "isoform_ac": "A2AH22-1", "locus": { "end_pos": 91766566, "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045705", "id": "ENSMUST00000045705", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000049258", "id": "ENSMUSP00000049258", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-1|AMRA1_MOUSE Isoform 1 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1300, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-2", "isoform_ac": "A2AH22-2", "locus": { "end_pos": 91766566, "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099712", "id": "ENSMUST00000099712", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097299", "id": "ENSMUSP00000097299", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-2|AMRA1_MOUSE Isoform 2 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1209, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-3", "isoform_ac": "A2AH22-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2AH22-3|AMRA1_MOUSE Isoform 3 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 781, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-4", "isoform_ac": "A2AH22-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2AH22-4|AMRA1_MOUSE Isoform 4 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 752, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-5", "isoform_ac": "A2AH22-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2AH22-5|AMRA1_MOUSE Isoform 5 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 896, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHQRSTSLK" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-6", "isoform_ac": "A2AH22-6", "locus": { "end_pos": 91766566, "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000111316", "id": "ENSMUST00000111316", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106948", "id": "ENSMUSP00000106948", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-6|AMRA1_MOUSE Isoform 6 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1240, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-7", "isoform_ac": "A2AH22-7", "locus": { "end_pos": 91766566, "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045699", "id": "ENSMUST00000045699", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000048898", "id": "ENSMUSP00000048898", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-7|AMRA1_MOUSE Isoform 7 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1180, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:228361", "resource": "KEGG Pathway", "id": "mmu:228361", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1632852", "resource": "Reactome", "id": "R-MMU-1632852", "name": "Macroautophagy" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AH22#function", "annotation": "Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22#function", "id": "A2AH22", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "MG53 overexpression could promote the expression of Ambra1 in C2C12 cells and restore mitochondrial autophagy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "These findings identify an Ambra1-dependent mechanism that drives inhibition/excitation imbalance in the hippocampus, contributing to abnormal brain activity reminiscent of neurodevelopmental disorders.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "Data support a role of AMBRA1/Ambra1 partial loss-of-function genotypes for female autistic traits. Moreover, they suggest Ambra1 heterozygous mice as a novel multifaceted and construct-valid genetic mouse model for female autism. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LNQ2-1", "protein_name": "Autophagy and beclin 1 regulator 1.", "sequence": { "length": 1300, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPTLDFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGNIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPNSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLNETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGTASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLLSEPGQLAERGLSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDSSNVGEAAGPSGEPRNR" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/826653/", "id": "826653", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/18204", "id": "18204", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9C0C7-1", "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1.", "sequence": { "length": 1298, "sequence": "MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/826653/", "id": "826653", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/18204", "id": "18204", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "ac": "NP_001074223.1", "name": "activating molecule in BECN1-regulated autophagy protein 1 isoform 2; activating molecule in BECN1-regulated autophagy protein 1; activating molecule in Beclin1-regulated autophagy.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "GTPase binding", "id": "GO:0051020" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "phagocytic vesicle", "id": "GO:0045335" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagosome", "id": "GO:0005776" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagy", "id": "GO:0006914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "neural tube development", "id": "GO:0021915" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagosome assembly", "id": "GO:0000045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "positive regulation of autophagy", "id": "GO:0010508" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cellular response to starvation", "id": "GO:0009267" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagy of mitochondrion", "id": "GO:0000422" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "mitophagy", "id": "GO:0000423" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010667", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "negative regulation of cardiac muscle cell apoptotic process", "id": "GO:0010667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043552", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "positive regulation of phosphatidylinositol 3-kinase activity", "id": "GO:0043552" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098780", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "response to mitochondrial depolarisation", "id": "GO:0098780" } ], "total": 13, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 388, "annotation": "n_glycosylation_sequon", "start_pos": 386 }, { "end_pos": 488, "annotation": "n_glycosylation_sequon", "start_pos": 486 }, { "end_pos": 493, "annotation": "n_glycosylation_sequon", "start_pos": 491 }, { "end_pos": 559, "annotation": "n_glycosylation_sequon", "start_pos": 557 }, { "end_pos": 562, "annotation": "n_glycosylation_sequon", "start_pos": 560 }, { "end_pos": 582, "annotation": "n_glycosylation_sequon", "start_pos": 580 }, { "end_pos": 593, "annotation": "n_glycosylation_sequon", "start_pos": 591 }, { "end_pos": 860, "annotation": "n_glycosylation_sequon", "start_pos": 858 }, { "end_pos": 880, "annotation": "n_glycosylation_sequon", "start_pos": 878 }, { "end_pos": 1274, "annotation": "n_glycosylation_sequon", "start_pos": 1272 }, { "end_pos": 1277, "annotation": "n_glycosylation_sequon", "start_pos": 1275 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1632852", "id": "R-MMU-1632852", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:228361", "id": "mmu:228361", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040506", "id": "ENSMUSG00000040506", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PPAECCQ/", "id": "PPAECCQ", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AH22", "id": "PR_A2AH22", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AH22*", "id": "A2AH22", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228361", "id": "228361", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2443564", "id": "2443564", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AH22", "disease": [], "mass": { "monoisotopic_mass": 142879.0, "chemical_mass": 142879.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "name": "Ambra1; Kiaa1736; 2310079H06Rik; A130023A14; AA474864; AV021921; D030051N19Rik; mKIAA1736.", "locus": { "end_pos": 91918849, "start_pos": 91730134, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040506", "id": "ENSMUSG00000040506", "database": "Ensembl Gene" } ] } } ] }