{
    "uniprot_canonical_ac": "A2A591-1", 
    "sequence": {
        "header": "sp|A2A591-1|KRA31_MOUSE Isoform 1 of Keratin-associated protein 3-1  OS=Mus musculus OX=10090 GN=Krtap3-1 PE=3 SV=1 CANONICAL=A2A591-1", 
        "length": 98, 
        "sequence": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHEISLLQPTCCDPCPPPCCQPEVYVPTCWLLNSCHPTPGLSGINLTTYVQPGCESPCEPCC"
    }, 
    "uniprot_id": "KRA31_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "keratin-associated protein 3-1", 
                "High-sulfur keratin protein; krtap3-1"
            ], 
            "uniprotkb": [
                "Keratin-associated protein 3-1", 
                "High-sulfur keratin protein"
            ]
        }, 
        "gene": {
            "refseq": [
                "Krtap3-1", 
                "2310003K17Rik", 
                "KAP3.1", 
                "KRTAP3.1"
            ], 
            "uniprotkb": [
                "Krtap3-1", 
                "2310003K17Rik", 
                "KAP3.1", 
                "KRTAP3.1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A591", 
                    "id": "A2A591", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Keratin-associated protein 3-1; High-sulfur keratin protein."
    }, 
    "publication": [
        {
            "title": "Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18721477", 
            "journal": "BMC evolutionary biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076000.1", 
                    "id": "NP_076000.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wu DD, Irwin DM, Zhang YP", 
            "date": "2008", 
            "pmid": "18721477"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A591#A2A591-1", 
            "isoform_ac": "A2A591-1", 
            "locus": {
                "end_pos": 99566290, 
                "start_pos": 99566583, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000055502", 
                        "id": "ENSMUST00000055502", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000053940", 
                        "id": "ENSMUSP00000053940", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A591-1|KRA31_MOUSE Isoform 1 of Keratin-associated protein 3-1  OS=Mus musculus OX=10090 GN=Krtap3-1 PE=3 SV=1 CANONICAL=A2A591-1", 
                "length": 98, 
                "sequence": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHEISLLQPTCCDPCPPPCCQPEVYVPTCWLLNSCHPTPGLSGINLTTYVQPGCESPCEPCC"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:69473", 
            "resource": "KEGG Pathway", 
            "id": "mmu:69473", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6805567", 
            "resource": "Reactome", 
            "id": "R-MMU-6805567", 
            "name": "Keratinization"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A591#function", 
            "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A591#function", 
                    "id": "A2A591", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9BYR8-1", 
            "protein_name": "Keratin-associated protein 3-1; Keratin-associated protein 3.1; High sulfur keratin-associated protein 3.1.", 
            "sequence": {
                "length": 98, 
                "sequence": "MYCCALRSCSVPTGPATTFCSFDKSCRCGVCLPSTCPHEISLLQPICCDTCPPPCCKPDTYVPTCWLLNNCHPTPGLSGINLTTYVQPGCESPCEPRC"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/309098/", 
                    "id": "309098", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/84874", 
                    "id": "84874", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "D3ZZR8-1", 
            "protein_name": "Keratin-associated protein 3-1.", 
            "sequence": {
                "length": 98, 
                "sequence": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHEISLLQPTCCDPCPPPCCQPEVYVPTCWLLNSCHPTPGLSGINLTTYVQPGCENPCEPCC"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/309098/", 
                    "id": "309098", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/84874", 
                    "id": "84874", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076000.1", 
        "ac": "NP_076000.1", 
        "name": "keratin-associated protein 3-1; High-sulfur keratin protein; krtap3-1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A591", 
                                "id": "A2A591", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "structural molecule activity", 
                        "id": "GO:0005198"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A591", 
                                "id": "A2A591", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "keratin filament", 
                        "id": "GO:0045095"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 83, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 81
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076000.1", 
            "id": "NP_076000.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6805567", 
            "id": "R-MMU-6805567", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:69473", 
            "id": "mmu:69473", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000047564", 
            "id": "ENSMUSG00000047564", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PPCCEPD/", 
            "id": "PPCCEPD", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007659", 
            "id": "IPR007659", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF04579", 
            "id": "PF04579", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23260", 
            "id": "PTHR23260", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A591", 
            "id": "PR_A2A591", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/69473", 
            "id": "69473", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1916723", 
            "id": "1916723", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2A591", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 10271.0, 
        "chemical_mass": 10271.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A591", 
            "name": "Krtap3-1; 2310003K17Rik; KAP3.1; KRTAP3.1.", 
            "locus": {
                "end_pos": 99566027, 
                "start_pos": 99566630, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000047564", 
                        "id": "ENSMUSG00000047564", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}