{
    "uniprot_canonical_ac": "A1L130-1", 
    "sequence": {
        "header": "tr|A1L130-1|A1L130_RAT Isoform 1 of Inhibitor of growth protein  OS=Rattus norvegicus OX=10116 GN=Ing4 PE=1 SV=1 CANONICAL=A1L130-1", 
        "length": 245, 
        "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK"
    }, 
    "uniprot_id": "A1L130_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "inhibitor of growth protein 4"
            ], 
            "uniprotkb": [
                "Inhibitor of growth protein"
            ]
        }, 
        "gene": {
            "refseq": [
                "Ing4"
            ], 
            "uniprotkb": [
                "Ing4", 
                "rCG_29756"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L130", 
                    "id": "A1L130", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Inhibitor of growth protein."
    }, 
    "publication": [
        {
            "title": "Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17517644", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhang X, Lin DH, Jin Y, Wang KS, Zhang Y, Babilonia E, Wang Z, Wang Z, Giebisch G, Han ZG, Wang WH", 
            "date": "2007", 
            "pmid": "17517644"
        }, 
        {
            "title": "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16387653", 
            "journal": "Molecular cell", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J", 
            "date": "2006", 
            "pmid": "16387653"
        }, 
        {
            "title": "ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15251430", 
            "journal": "FEBS letters", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhang X, Xu LS, Wang ZQ, Wang KS, Li N, Cheng ZH, Huang SZ, Wei DZ, Han ZG", 
            "date": "2004", 
            "pmid": "15251430"
        }, 
        {
            "title": "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15029197", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK", 
            "date": "2004", 
            "pmid": "15029197"
        }, 
        {
            "title": "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12750254", 
            "journal": "Cancer research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC", 
            "date": "2003", 
            "pmid": "12750254"
        }, 
        {
            "title": "Mouse ING1 homologue, a protein interacting with A1, enhances cell death and is inhibited by A1 in mammary epithelial cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11888890", 
            "journal": "Cancer research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ha S, Lee S, Chung M, Choi Y", 
            "date": "2002", 
            "pmid": "11888890"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L130#A1L130-1", 
            "isoform_ac": "A1L130-1", 
            "locus": {
                "end_pos": 157554798, 
                "start_pos": 157562502, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000024116", 
                        "id": "ENSRNOT00000024116", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000024116", 
                        "id": "ENSRNOP00000024116", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A1L130-1|A1L130_RAT Isoform 1 of Inhibitor of growth protein  OS=Rattus norvegicus OX=10116 GN=Ing4 PE=1 SV=1 CANONICAL=A1L130-1", 
                "length": 245, 
                "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:297597", 
            "resource": "KEGG Pathway", 
            "id": "rno:297597", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214847", 
            "resource": "Reactome", 
            "id": "R-RNO-3214847", 
            "name": "HATs acetylate histones"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
            "annotation": "Provide evidence for the role of ING4 in mediating the effect of low K intake on renal outer medullary K channel activity by stimulation of p38 and ERK mitogen-activated protein kinase", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
                    "id": "NP_001073356.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9UNL4-1", 
            "protein_name": "Inhibitor of growth protein 4; p29ING4.", 
            "sequence": {
                "length": 249, 
                "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/22952", 
                    "id": "22952", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/547926/", 
                    "id": "547926", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q8C0D7-1", 
            "protein_name": "Inhibitor of growth protein 4; p29ING4.", 
            "sequence": {
                "length": 249, 
                "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/22952", 
                    "id": "22952", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/547926/", 
                    "id": "547926", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
        "ac": "NP_001073356.1", 
        "name": "inhibitor of growth protein 4.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035064", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "methylated histone binding", 
                        "id": "GO:0035064"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription coactivator activity", 
                        "id": "GO:0003713"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intermediate filament cytoskeleton", 
                        "id": "GO:0045111"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone acetyltransferase complex", 
                        "id": "GO:0000123"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of apoptotic process", 
                        "id": "GO:0043065"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell population proliferation", 
                        "id": "GO:0008285"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "apoptotic process", 
                        "id": "GO:0006915"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007050", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell cycle arrest", 
                        "id": "GO:0007050"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription, DNA-templated", 
                        "id": "GO:0045892"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA replication", 
                        "id": "GO:0006260"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045926", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of growth", 
                        "id": "GO:0045926"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043966", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H3 acetylation", 
                        "id": "GO:0043966"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006978", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", 
                        "id": "GO:0006978"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043981", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H4-K5 acetylation", 
                        "id": "GO:0043981"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043982", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H4-K8 acetylation", 
                        "id": "GO:0043982"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043983", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L130", 
                                "id": "A1L130", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H4-K12 acetylation", 
                        "id": "GO:0043983"
                    }
                ], 
                "total": 12, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073356.1", 
            "id": "NP_001073356.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214847", 
            "id": "R-RNO-3214847", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:297597", 
            "id": "rno:297597", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000023363", 
            "id": "ENSRNOG00000023363", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SNFGNVH/", 
            "id": "SNFGNVH", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", 
            "id": "IPR001965", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", 
            "id": "IPR011011", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", 
            "id": "IPR013083", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", 
            "id": "IPR019786", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", 
            "id": "IPR019787", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024610", 
            "id": "IPR024610", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028647", 
            "id": "IPR028647", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028651", 
            "id": "IPR028651", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF12998", 
            "id": "PF12998", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333:SF40", 
            "id": "PTHR10333:SF40", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333", 
            "id": "PTHR10333", 
            "database": "PANTHER"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/297597", 
            "id": "297597", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309407", 
            "id": "1309407", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A1L130", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 28087.0, 
        "chemical_mass": 28087.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L130", 
            "name": "Ing4; rCG_29756.", 
            "locus": {
                "end_pos": 157563352, 
                "start_pos": 157554794, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000023363", 
                        "id": "ENSRNOG00000023363", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}