{ "uniprot_canonical_ac": "A1KZ92-1", "sequence": { "header": "sp|A1KZ92-1|PXDNL_HUMAN Isoform 1 of Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=3 CANONICAL=A1KZ92-1", "length": 1463, "sequence": "MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR" }, "uniprot_id": "PXDNL_HUMAN", "enzyme_annotation": [ { "ec": "1.11.1.7", "activity": "2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O." }, { "ec": "1.11.1.7", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "peroxidasin-like protein precursor", "peroxidasin-like protein; cardiovascular peroxidase 2; cardiac peroxidase; vascular peroxidase 2; peroxidasin homolog-like; polysomal ribonuclease 1 homolog" ], "uniprotkb": [ "Peroxidasin-like protein", "1.11.1.7", "polysomal ribonuclease 1", "PRM1", "Cardiac peroxidase", "Vascular peroxidase 2" ] }, "gene": { "refseq": [], "uniprotkb": [ "PXDNL", "VPO2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Peroxidasin-like protein; 1.11.1.7; polysomal ribonuclease 1; PRM1; Cardiac peroxidase; Vascular peroxidase 2." }, "publication": [ { "title": "Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22543864", "journal": "RNA", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "authors": "Han J., Schoenberg D.R., Patil D.P., Otsuka Y., Bakthavachalu B., Gu S.Q., Guda C.", "date": "2012", "pmid": "22543864" }, { "title": "Identification and characterization of VPO1, a new animal heme-containing peroxidase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18929642", "journal": "Free Radic. Biol. Med.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "authors": "Cao Z., Cheng G., Lambeth J.D., Pagano P.J., Salerno J.C.", "date": "2008", "pmid": "18929642" }, { "title": "An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12923263", "journal": "RNA", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "authors": "Schoenberg D.R., Bremer K.A., Stevens A.", "date": "2003", "pmid": "12923263" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92#PTM_processing", "id": "A1KZ92", "database": "UniProtKB" } ], "relation": "attached", "position": 387, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [ { "start_pos": 857, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (2/5): patient freq. (1.1%); num. of cancers (5).", "sequence_org": "A", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "V", "subjects_tested": "93", "end_pos": 857, "type": "Point mutation" }, { "start_pos": 251, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs776904737.", "sequence_org": "V", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "I", "subjects_tested": "1144", "end_pos": 251, "type": "Point mutation" }, { "start_pos": 235, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs757076660.", "sequence_org": "R", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "Liver cancer" }, "sequence_mut": "Q", "subjects_tested": "412", "end_pos": 235, "type": "Point mutation" }, { "start_pos": 1137, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "S", "disease": { "doid": "4159", "url": "http://disease-ontology.org/term/DOID:4159", "icd10": "", "name": "Skin cancer" }, "sequence_mut": "L", "subjects_tested": "820", "end_pos": 1137, "type": "Point mutation" }, { "start_pos": 857, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (5).", "sequence_org": "A", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "V", "subjects_tested": "1042", "end_pos": 857, "type": "Point mutation" }, { "start_pos": 1137, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "S", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "L", "subjects_tested": "742", "end_pos": 1137, "type": "Point mutation" }, { "start_pos": 905, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.3", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs766523476.", "sequence_org": "R", "disease": { "doid": "1793", "url": "http://disease-ontology.org/term/DOID:1793", "icd10": "", "name": "Pancreatic cancer" }, "sequence_mut": "W", "subjects_tested": "399", "end_pos": 905, "type": "Point mutation" }, { "start_pos": 523, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "1.5", "annotation": "Filters passed (1/5): patient freq. (1.5%).", "sequence_org": "E", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "*", "subjects_tested": "66", "end_pos": 523, "type": "Point mutation" }, { "start_pos": 945, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (4).", "sequence_org": "A", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "T", "subjects_tested": "456", "end_pos": 945, "type": "Point mutation" }, { "start_pos": 833, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "S", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "C", "subjects_tested": "50", "end_pos": 833, "type": "Point mutation" }, { "start_pos": 1402, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. (1.1%).", "sequence_org": "P", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "S", "subjects_tested": "94", "end_pos": 1402, "type": "Point mutation" }, { "start_pos": 616, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "D", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "A", "subjects_tested": "50", "end_pos": 616, "type": "Point mutation" }, { "start_pos": 493, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs752274536.", "sequence_org": "S", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "L", "subjects_tested": "558", "end_pos": 493, "type": "Point mutation" }, { "start_pos": 946, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs1432085650.", "sequence_org": "R", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "*", "subjects_tested": "1144", "end_pos": 946, "type": "Point mutation" }, { "start_pos": 945, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (4).", "sequence_org": "A", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "T", "subjects_tested": "742", "end_pos": 945, "type": "Point mutation" }, { "start_pos": 864, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (5). In dbSNP: rs936865843.", "sequence_org": "R", "disease": { "doid": "10534", "url": "http://disease-ontology.org/term/DOID:10534", "icd10": "", "name": "Stomach cancer" }, "sequence_mut": "C", "subjects_tested": "1044", "end_pos": 864, "type": "Point mutation" }, { "start_pos": 864, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (5). In dbSNP: rs936865843.", "sequence_org": "R", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "C", "subjects_tested": "1514", "end_pos": 864, "type": "Point mutation" }, { "start_pos": 559, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "V", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "L", "subjects_tested": "50", "end_pos": 559, "type": "Point mutation" }, { "start_pos": 684, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "L", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "F", "subjects_tested": "50", "end_pos": 684, "type": "Point mutation" }, { "start_pos": 373, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.1", "annotation": "Filters passed (1/5): patient freq. (2.1%).", "sequence_org": "G", "disease": { "doid": "2531", "url": "http://disease-ontology.org/term/DOID:2531", "icd10": "", "name": "Hematologic cancer" }, "sequence_mut": "*", "subjects_tested": "48", "end_pos": 373, "type": "Point mutation" }, { "start_pos": 857, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.5", "annotation": "Filters passed (1/5): num. of cancers (5).", "sequence_org": "A", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "Esophageal cancer" }, "sequence_mut": "V", "subjects_tested": "191", "end_pos": 857, "type": "Point mutation" }, { "start_pos": 235, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.6", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs757076660.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "Q", "subjects_tested": "162", "end_pos": 235, "type": "Point mutation" }, { "start_pos": 905, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs766523476.", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "W", "subjects_tested": "558", "end_pos": 905, "type": "Point mutation" }, { "start_pos": 781, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "R", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 781, "type": "Point mutation" }, { "start_pos": 946, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.8", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs1432085650.", "sequence_org": "R", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "*", "subjects_tested": "118", "end_pos": 946, "type": "Point mutation" }, { "start_pos": 493, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs752274536.", "sequence_org": "S", "disease": { "doid": "4159", "url": "http://disease-ontology.org/term/DOID:4159", "icd10": "", "name": "Skin cancer" }, "sequence_mut": "L", "subjects_tested": "820", "end_pos": 493, "type": "Point mutation" }, { "start_pos": 408, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "Q", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "H", "subjects_tested": "50", "end_pos": 408, "type": "Point mutation" }, { "start_pos": 945, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "A", "disease": { "doid": "10534", "url": "http://disease-ontology.org/term/DOID:10534", "icd10": "", "name": "Stomach cancer" }, "sequence_mut": "V", "subjects_tested": "1044", "end_pos": 945, "type": "Point mutation" }, { "start_pos": 728, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "1.4", "annotation": "Filters passed (1/5): patient freq. (1.4%). In dbSNP: rs776364671.", "sequence_org": "R", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "C", "subjects_tested": "72", "end_pos": 728, "type": "Point mutation" }, { "start_pos": 905, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (4). In dbSNP: rs766523476.", "sequence_org": "R", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "W", "subjects_tested": "499", "end_pos": 905, "type": "Point mutation" }, { "start_pos": 857, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "0.3", "annotation": "Filters passed (1/5): num. of cancers (5).", "sequence_org": "A", "disease": { "doid": "1793", "url": "http://disease-ontology.org/term/DOID:1793", "icd10": "", "name": "Pancreatic cancer" }, "sequence_mut": "V", "subjects_tested": "399", "end_pos": 857, "type": "Point mutation" }, { "start_pos": 74, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. 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(2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "F", "subjects_tested": "50", "end_pos": 1298, "type": "Point mutation" }, { "start_pos": 864, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "2.1", "annotation": "Filters passed (1/5): patient freq. (2.1%).", "sequence_org": "R", "disease": { "doid": "2531", "url": "http://disease-ontology.org/term/DOID:2531", "icd10": "", "name": "Hematologic cancer" }, "sequence_mut": "H", "subjects_tested": "48", "end_pos": 864, "type": "Point mutation" }, { "start_pos": 1006, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1KZ92", "id": "A1KZ92", "database": "BioMuta" } ], "frequency": "1.5", "annotation": "Filters passed (1/5): patient freq. (1.5%).", "sequence_org": "G", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "C", "subjects_tested": "66", "end_pos": 1006, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92#A1KZ92-1", "isoform_ac": "A1KZ92-1", "locus": { "end_pos": 51319894, "start_pos": 51809344, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000356297", "id": "ENST00000356297", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000348645", "id": "ENSP00000348645", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1KZ92-1|PXDNL_HUMAN Isoform 1 of Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=3 CANONICAL=A1KZ92-1", "length": 1463, "sequence": "MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR" } }, { "url": "https://www.uniprot.org/uniprot/A1KZ92#K4DIA6-1", "isoform_ac": "K4DIA6-1", "locus": { "end_pos": 51320851, "start_pos": 51409421, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000522628", "id": "ENST00000522628", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000429855", "id": "ENSP00000429855", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|K4DIA6-1|PXDNL_HUMAN Computationally mapped isoform of Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=1 CANONICAL=A1KZ92-1", "length": 582, "sequence": "NNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADKQAGGTPEAGRVYRC" } }, { "url": "https://www.uniprot.org/uniprot/A1KZ92#A1KZ92-2", "isoform_ac": "A1KZ92-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A1KZ92-2|PXDNL_HUMAN Isoform 2 of Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=3 CANONICAL=A1KZ92-1", "length": 1316, "sequence": "MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADKQAGGTPEAGRVYRC" } }, { "url": "https://www.uniprot.org/uniprot/A1KZ92#H0YAV0-1", "isoform_ac": "H0YAV0-1", "locus": { "end_pos": 51319893, "start_pos": 51408979, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000522933", "id": "ENST00000522933", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000428114", "id": "ENSP00000428114", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H0YAV0-1|PXDNL_HUMAN Computationally mapped isoform of Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=1 CANONICAL=A1KZ92-1", "length": 537, "sequence": "XAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR" } }, { "url": "https://www.uniprot.org/uniprot/A1KZ92#A1KZ92-3", "isoform_ac": "A1KZ92-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A1KZ92-3|PXDNL_HUMAN Isoform 3 of Peroxidasin-like protein OS=Homo sapiens OX=9606 GN=PXDNL PE=1 SV=3 CANONICAL=A1KZ92-1", "length": 515, "sequence": "MLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADKQAGGTPEAGRVYRC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:137902", "resource": "KEGG Pathway", "id": "hsa:137902", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92#function", "annotation": "Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92#function", "id": "A1KZ92", "database": "UniProtKB" } ] } ], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "peroxidasin-like protein precursor; peroxidasin-like protein; cardiovascular peroxidase 2; cardiac peroxidase; vascular peroxidase 2; peroxidasin homolog-like; polysomal ribonuclease 1 homolog.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "endonuclease activity", "id": "GO:0004519" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "heme binding", "id": "GO:0020037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "peroxidase activity", "id": "GO:0004601" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "response to oxidative stress", "id": "GO:0006979" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055114", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "oxidation-reduction process", "id": "GO:0055114" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1KZ92", "id": "A1KZ92", "database": "UniProtKB" } ], "name": "hydrogen peroxide catabolic process", "id": "GO:0042744" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 273, "annotation": "n_glycosylation_sequon", "start_pos": 271 }, { "end_pos": 389, "annotation": "n_glycosylation_sequon", "start_pos": 387 }, { "end_pos": 403, "annotation": "n_glycosylation_sequon", "start_pos": 401 }, { "end_pos": 531, "annotation": "n_glycosylation_sequon", "start_pos": 529 }, { "end_pos": 628, "annotation": "n_glycosylation_sequon", "start_pos": 626 }, { "end_pos": 707, "annotation": "n_glycosylation_sequon", "start_pos": 705 }, { "end_pos": 719, "annotation": "n_glycosylation_sequon", "start_pos": 717 }, { "end_pos": 1070, "annotation": "n_glycosylation_sequon", "start_pos": 1068 }, { "end_pos": 1163, "annotation": "n_glycosylation_sequon", "start_pos": 1161 }, { "end_pos": 1285, "annotation": "n_glycosylation_sequon", "start_pos": 1283 }, { "end_pos": 1354, "annotation": "n_glycosylation_sequon", "start_pos": 1352 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653252.3", "id": "NP_653252.3", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26359", "id": "26359", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A1KZ92", "id": "A1KZ92", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A1KZ92", "id": "NX_A1KZ92", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PXDNL", "id": "PXDNL", "database": "GeneCards" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:137902", "id": "hsa:137902", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000147485", "id": "ENSG00000147485", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/RYENGFN/", "id": "RYENGFN", "database": "OMA" }, { "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.11.1.7&UniProtAcc=A1KZ92", "id": "1.11.1.7", "database": "BRENDA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09826", "id": "cd09826", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029610", "id": "IPR029610", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034824", "id": "IPR034824", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010255", "id": "IPR010255", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019791", "id": "IPR019791", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037120", "id": "IPR037120", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "id": "IPR003598", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "id": "IPR003599", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "id": "IPR007110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "id": "IPR013783", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "id": "IPR036179", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "id": "IPR000483", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "id": "IPR003591", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "id": "IPR013098", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "id": "IPR001007", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03098", "id": "PF03098", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13855", "id": "PF13855", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07679", "id": "PF07679", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00093", "id": "PF00093", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11475:SF38", "id": "PTHR11475:SF38", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1KZ92", "id": "PR_A1KZ92", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A1KZ92*", "id": "A1KZ92", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/137902", "id": "137902", "database": "GeneID" } ], "expression_disease": [ { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1KZ92", "id": "A1KZ92", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1KZ92", "id": "A1KZ92", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1KZ92", "id": "A1KZ92", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1KZ92", "id": "A1KZ92", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1KZ92", "id": "A1KZ92", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1KZ92", "id": "A1KZ92", "database": "BioXpress" } ] }, 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