{ "uniprot_canonical_ac": "A0FGR8-1", "sequence": { "header": "sp|A0FGR8-1|ESYT2_HUMAN Isoform 1 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 921, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" }, "uniprot_id": "ESYT2_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "extended synaptotagmin-2 isoform 2", "family with sequence similarity 62 (C2 domain containing), member B; chr2 synaptotagmin; extended synaptotagmin protein 2; extended synaptotagmin like protein 2" ], "uniprotkb": [ "Extended synaptotagmin-2", "E-Syt2", "Chr2Syt" ] }, "gene": { "refseq": [], "uniprotkb": [ "ESYT2", "FAM62B", "KIAA1228" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Extended synaptotagmin-2; E-Syt2; Chr2Syt.", "short": "E-Syt2" }, "publication": [ { "title": "Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30220461", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Jiang H., Li S., He C., Xiao X., Young S.G., Ikonen E., Lee R., Gatta A.T., Levine T.P., Hong C., Ferrari A., Fairall L., Tontonoz P., Schwabe J.W.R., Lee S.D., Sandhu J., Pfisterer S.G., Bentolila L.A., Ferng A., Ford D.A., Gurnett J.E., Hartman C.L., Orozco J.L., Strugatsky D., Vashi D., Weston T.A.", "date": "2018", "pmid": "30220461" }, { "title": "Structure and Ca(2+)-binding properties of the tandem C(2) domains of E-Syt2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24373768", "journal": "Structure", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Xu J., Sudhof T.C., Zhou A., Tomchick D.R., Bacaj T., Rizo J.", "date": "2014", "pmid": "24373768" }, { "title": "Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24847877", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Wu X., De Camilli P., Wenk M.R., Reinisch K.M., Torta F., Schauder C.M., Narayanaswamy P., Saheki Y.", "date": "2014", "pmid": "24847877" }, { "title": "PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23791178", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Gracheva E.O., De Camilli P., Borgese N., Pirruccello M., Bagriantsev S.N., Colombo S.F., Giordano F., Idevall-Hagren O., Milosevic I., Saheki Y.", "date": "2013", "pmid": "23791178" }, { "title": "Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20833364", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Moss T., Baril J., Bellenfant S., Guillou F., Jean S., Mikryukov A., Tremblay M.G.", "date": "2010", "pmid": "20833364" }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18691976", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Bairlein M., Daub H., Gnad F., Greff Z., Keri G., Korner R., Mann M., Olsen J.V., Oppermann F.S., Stemmann O.", "date": "2008", "pmid": "18691976" }, { "title": "E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17360437", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Suedhof T.C., Chang W.-P., Min S.-W.", "date": "2007", "pmid": "17360437" }, { "title": "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17924679", "journal": "J. Proteome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Chan K.C., Dimitrov D.S., Issaq H.J., Veenstra T.D., Yu L.R., Zhu Z.", "date": "2007", "pmid": "17924679" }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17081983", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Blagoev B., Gnad F., Kumar C., Macek B., Mann M., Mortensen P., Olsen J.V.", "date": "2006", "pmid": "17081983" }, { "title": "Genomic analysis of synaptotagmin genes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11543631", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Craxton M.A.", "date": "2001", "pmid": "11543631" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-2", "isoform_ac": "A0FGR8-2", "locus": { "end_pos": 158734210, "start_pos": 158829562, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000652148", "id": "ENST00000652148", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000499020", "id": "ENSP00000499020", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0FGR8-2|ESYT2_HUMAN Isoform 2 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 893, "sequence": "MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#H7BXI1-1", "isoform_ac": "H7BXI1-1", "locus": { "end_pos": 158734210, "start_pos": 158829418, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000275418", "id": "ENST00000275418", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000275418", "id": "ENSP00000275418", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H7BXI1-1|ESYT2_HUMAN Computationally mapped isoform of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=2 CANONICAL=A0FGR8-1", "length": 866, "sequence": "MSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-4", "isoform_ac": "A0FGR8-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A0FGR8-4|ESYT2_HUMAN Isoform 4 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 527, "sequence": "MWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTSQSRSRPPASPRTSRCPSPPRSCGKG" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0A499FIX8-1", "isoform_ac": "A0A499FIX8-1", "locus": { "end_pos": 158734210, "start_pos": 158829418, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000251527", "id": "ENST00000251527", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000251527", "id": "ENSP00000251527", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A499FIX8-1|ESYT2_HUMAN Computationally mapped isoform of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 845, "sequence": "MSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-5", "isoform_ac": "A0FGR8-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A0FGR8-5|ESYT2_HUMAN Isoform 5 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 328, "sequence": "MPVLPPCVLQVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0A087WXU3-1", "isoform_ac": "A0A087WXU3-1", "locus": { "end_pos": 158734210, "start_pos": 158830038, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000613624", "id": "ENST00000613624", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000481296", "id": "ENSP00000481296", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WXU3-1|ESYT2_HUMAN Computationally mapped isoform of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 921, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-6", "isoform_ac": "A0FGR8-6", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A0FGR8-6|ESYT2_HUMAN Isoform 6 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 942, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-1", "isoform_ac": "A0FGR8-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A0FGR8-1|ESYT2_HUMAN Isoform 1 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 921, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:57488", "resource": "KEGG Pathway", "id": "hsa:57488", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660662", "resource": "Reactome", "id": "R-HSA-1660662", "name": "Glycosphingolipid metabolism" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8#function", "annotation": "Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8#function", "id": "A0FGR8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TZZ7-1", "protein_name": "Extended synaptotagmin-2; E-Syt2.", "sequence": { "length": 845, "sequence": "MSSAGGEGPEAGPGRAGGRSEPEAPGSALSVDLPGLLGQLARSFALLLPVYALGYLGLSFSWVLLALGLLAWCRRSRGLKASRLCRALALLEDEEQAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANAHLSTFSFTKVDVGQQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLKLEWLTLMPDAANLDKVLADIRADKDQASDGLSSALLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTSEPVWEENFTFFIHNPRRQDLEVEVKDEQHQCSLGSLRIPLSQLLTSDNMTINQRFQLSNSGPNSTLKMKIALRVLHLEKQERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSASPGTGGANTAPSTPVMGVDDKPAMEEKPQPPEASPLGHRDLGRSSSSLLASPSHIAAKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVVLASEELAKGWTQWYDLTEDGTRPQVIT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32699", "id": "32699", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "", "ac": "", "name": "extended synaptotagmin-2 isoform 2; family with sequence similarity 62 (C2 domain containing), member B; chr2 synaptotagmin; extended synaptotagmin protein 2; extended synaptotagmin like protein 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "cadherin binding", "id": "GO:0045296" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "calcium-dependent phospholipid binding", "id": "GO:0005544" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "phosphatidylethanolamine binding", "id": "GO:0008429" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "phosphatidylcholine binding", "id": "GO:0031210" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "phosphatidylinositol binding", "id": "GO:0035091" } ], "total": 8, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "intrinsic component of endoplasmic reticulum membrane", "id": "GO:0031227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044232", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "organelle membrane contact site", "id": "GO:0044232" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "integral component of plasma membrane", "id": "GO:0005887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031234", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "extrinsic component of cytoplasmic side of plasma membrane", "id": "GO:0031234" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "lipid transport", "id": "GO:0006869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endocytosis", "id": "GO:0006897" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006687", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "glycosphingolipid metabolic process", "id": "GO:0006687" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061817", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane tethering", "id": "GO:0061817" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 201, "annotation": "n_glycosylation_sequon", "start_pos": 199 }, { "end_pos": 332, "annotation": "n_glycosylation_sequon", "start_pos": 330 }, { "end_pos": 435, "annotation": "n_glycosylation_sequon", "start_pos": 433 }, { "end_pos": 513, "annotation": "n_glycosylation_sequon", "start_pos": 511 }, { "end_pos": 589, "annotation": "n_glycosylation_sequon", "start_pos": 587 }, { "end_pos": 645, "annotation": "n_glycosylation_sequon", "start_pos": 643 }, { "end_pos": 780, "annotation": "n_glycosylation_sequon", "start_pos": 778 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065779.1", "id": "NP_065779.1", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=22211", "id": "22211", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A0FGR8", "id": "A0FGR8", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A0FGR8", "id": "NX_A0FGR8", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ESYT2", "id": "ESYT2", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660662", "id": "R-HSA-1660662", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:57488", "id": "hsa:57488", "database": "KEGG Pathway" }, { "url": "https://www.rcsb.org/structure/2DMG", "id": "2DMG", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/4NPJ", "id": "4NPJ", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/4NPK", "id": "4NPK", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/4P42", "id": "4P42", "database": "PDB" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117868", "id": "ENSG00000117868", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04030", "id": "cd04030", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04050", "id": "cd04050", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08391", "id": "cd08391", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "id": "IPR000008", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "id": "IPR035892", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031468", "id": "IPR031468", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037733", "id": "IPR037733", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037749", "id": "IPR037749", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037752", "id": "IPR037752", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039010", "id": "IPR039010", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00168", "id": "PF00168", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17047", "id": "PF17047", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0FGR8", "id": "PR_A0FGR8", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0FGR8*", "id": "A0FGR8", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/57488", "id": "57488", "database": "GeneID" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0FGR8", "id": "A0FGR8", "database": "BioXpress" } ] } ], "uniprot_ac": "A0FGR8", "disease": [], "mass": { "monoisotopic_mass": 102357.0, "chemical_mass": 102357.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=R-HSA-1660662", "id": "R-HSA-1660662", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "name": "ESYT2; FAM62B; KIAA1228.", "locus": { "end_pos": 158730995, "start_pos": 158830253, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000117868", "id": "ENSG00000117868", "database": "Ensembl Gene" } ] } } ] }