{ "uniprot_canonical_ac": "A0AV96-1", "sequence": { "header": "sp|A0AV96-1|RBM47_HUMAN Isoform 1 of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=2 CANONICAL=A0AV96-1", "length": 593, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY" }, "uniprot_id": "RBM47_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "RNA-binding protein 47 isoform a", "RNA-binding protein 47" ], "uniprotkb": [ "RNA-binding protein 47", "RNA-binding motif protein 47" ] }, "gene": { "refseq": [ "RBM47", "NET18" ], "uniprotkb": [ "RBM47", "NET18" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "RNA-binding protein 47; RNA-binding motif protein 47." }, "publication": [ { "title": "miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30403177", "journal": "Medecine sciences : M/S", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ], "authors": "Jiang QQ, Liu WB", "date": "2018", "pmid": "30403177" }, { "title": "RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26923328", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ], "authors": "Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D", "date": "2016", "pmid": "26923328" }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014", "pmid": "24129315" }, { "title": "Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24898756", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ], "authors": "Vanharanta S, Marney CB, Shu W, Valiente M, Zou Y, Mele A, Darnell RB, Massague J", "date": "2014", "pmid": "24898756" }, { "title": "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22658674", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ], "authors": "Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW", "date": "2012", "pmid": "22658674" }, { "title": "Transcriptome analysis of human gastric cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16341674", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ], "authors": "Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS", "date": "2005", "pmid": "16341674" } ], "glycosylation": [], "mutation": [ { "start_pos": 161, "subjects_positive": "36", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "2.4", "annotation": "Filters passed (2/5): patient freq. (2.4%); patient count (36/1514).", "sequence_org": "M", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "L", "subjects_tested": "1514", "end_pos": 161, "type": "Point mutation" }, { "start_pos": 559, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 559, "type": "Point mutation" }, { "start_pos": 284, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "1.3", "annotation": "Filters passed (1/5): patient freq. (1.3%).", "sequence_org": "A", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "T", "subjects_tested": "78", "end_pos": 284, "type": "Point mutation" }, { "start_pos": 123, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "E", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "K", "subjects_tested": "742", "end_pos": 123, "type": "Point mutation" }, { "start_pos": 123, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "E", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "K", "subjects_tested": "678", "end_pos": 123, "type": "Point mutation" }, { "start_pos": 376, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "C", "subjects_tested": "50", "end_pos": 376, "type": "Point mutation" }, { "start_pos": 330, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. (1.1%).", "sequence_org": "A", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "V", "subjects_tested": "93", "end_pos": 330, "type": "Point mutation" }, { "start_pos": 458, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "E", "subjects_tested": "50", "end_pos": 458, "type": "Point mutation" }, { "start_pos": 123, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "E", "disease": { "doid": "4159", "url": "http://disease-ontology.org/term/DOID:4159", "icd10": "", "name": "Skin cancer" }, "sequence_mut": "K", "subjects_tested": "820", "end_pos": 123, "type": "Point mutation" }, { "start_pos": 29, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "T", "subjects_tested": "50", "end_pos": 29, "type": "Point mutation" }, { "start_pos": 491, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0AV96", "id": "A0AV96", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 491, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0AV96#A0AV96-1", "isoform_ac": "A0AV96-1", "locus": { "end_pos": 40425907, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000381793", "id": "ENST00000381793", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000371212", "id": "ENSP00000371212", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0AV96-1|RBM47_HUMAN Isoform 1 of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=2 CANONICAL=A0AV96-1", "length": 593, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6RFL5-1", "isoform_ac": "D6RFL5-1", "locus": { "end_pos": 40438483, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000514782", "id": "ENST00000514782", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000426542", "id": "ENSP00000426542", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RFL5-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=1 CANONICAL=A0AV96-1", "length": 137, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIR" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#A0AV96-2", "isoform_ac": "A0AV96-2", "locus": { "end_pos": 40425907, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000381795", "id": "ENST00000381795", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000371214", "id": "ENSP00000371214", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0AV96-2|RBM47_HUMAN Isoform 2 of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=2 CANONICAL=A0AV96-1", "length": 524, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6RCT1-1", "isoform_ac": "D6RCT1-1", "locus": { "end_pos": 40438717, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000505220", "id": "ENST00000505220", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000425507", "id": "ENSP00000425507", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RCT1-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=1 CANONICAL=A0AV96-1", "length": 59, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPP" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6R9M7-1", "isoform_ac": "D6R9M7-1", "locus": { "end_pos": 40438420, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000505414", "id": "ENST00000505414", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000423527", "id": "ENSP00000423527", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6R9M7-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=8 CANONICAL=A0AV96-1", "length": 158, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGI" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6RBP6-1", "isoform_ac": "D6RBP6-1", "locus": { "end_pos": 40438555, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000511598", "id": "ENST00000511598", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000424019", "id": "ENSP00000424019", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RBP6-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=8 CANONICAL=A0AV96-1", "length": 113, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGY" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6R9D6-1", "isoform_ac": "D6R9D6-1", "locus": { "end_pos": 40436830, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000510871", "id": "ENST00000510871", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000422945", "id": "ENSP00000422945", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6R9D6-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=1 CANONICAL=A0AV96-1", "length": 393, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKDTILETHPASLPLVLRRHA" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6REZ6-1", "isoform_ac": "D6REZ6-1", "locus": { "end_pos": 40438315, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000513473", "id": "ENST00000513473", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000421589", "id": "ENSP00000421589", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6REZ6-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=1 CANONICAL=A0AV96-1", "length": 193, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKN" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6RA49-1", "isoform_ac": "D6RA49-1", "locus": { "end_pos": 40438525, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000507180", "id": "ENST00000507180", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000423398", "id": "ENSP00000423398", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RA49-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=8 CANONICAL=A0AV96-1", "length": 123, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHE" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#D6RBS9-1", "isoform_ac": "D6RBS9-1", "locus": { "end_pos": 40438243, "start_pos": 40438893, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000515053", "id": "ENST00000515053", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000422564", "id": "ENSP00000422564", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RBS9-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=1 CANONICAL=A0AV96-1", "length": 217, "sequence": "MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPG" } }, { "url": "https://www.uniprot.org/uniprot/A0AV96#B7Z8Z7-1", "isoform_ac": "B7Z8Z7-1", "locus": { "end_pos": 40425907, "start_pos": 40438779, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000514014", "id": "ENST00000514014", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000423243", "id": "ENSP00000423243", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B7Z8Z7-1|RBM47_HUMAN Computationally mapped isoform of RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=1 CANONICAL=A0AV96-1", "length": 555, "sequence": "MERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:54502", "resource": "KEGG Pathway", "id": "hsa:54502", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "annotation": "MiR-25 could directly target the RNA-binding motif protein 47 (RBM47). RBM47 is a promising target for the treatment of melanoma.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "annotation": "Our findings, together with the enhanced tumor formation and metastasis of xenografted mice by knockdown of the RBM47 expression, suggested tumor-suppressive roles for RBM47 through the inhibition of Nrf2 activity Erratum:[Oncogene. 2017 Jun 12;:. PMID: 28604754]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "annotation": "RBM47 is an RNA-binding protein that can suppress breast cancer progression Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q91WT8-1", "protein_name": "RNA-binding protein 47; RNA-binding motif protein 47.", "sequence": { "length": 590, "sequence": "MTAEDSATAMNSDPTVGSSTKVPEGVAGAPNEAALLALIERTGYTMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGGGGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRTPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISPVNPVAIKPGTVAIPAIGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGGYAGYIPQAFPAALQVPIHDVYQTY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/36932", "id": "36932", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/609647/", "id": "609647", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q66H68-1", "protein_name": "RNA-binding protein 47; RNA-binding motif protein 47.", "sequence": { "length": 590, "sequence": "MTAEDSTTAMNSDPTVGSSTKVPEGVAGAPNEAALLALMERTGYNMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKRSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGGGGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRTPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISAVNPVAIKPGTVAIPAIGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVSTPPPFQGRPITPVYTVAPNVPRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGGYAGYIPQAFPAALQVPIHDVYQTY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/36932", "id": "36932", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/609647/", "id": "609647", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "ac": "NP_001092104.1", "name": "RNA-binding protein 47 isoform a; RNA-binding protein 47.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "mRNA binding", "id": "GO:0003729" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016554", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "cytidine to uridine editing", "id": "GO:0016554" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "id": "A0AV96", "database": "UniProtKB" } ], "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 304, "annotation": "n_glycosylation_sequon", "start_pos": 302 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092104.1", "id": "NP_001092104.1", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30358", "id": "30358", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A0AV96", "id": "A0AV96", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A0AV96", "id": "NX_A0AV96", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RBM47", "id": "RBM47", "database": "GeneCards" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:54502", "id": "hsa:54502", "database": "KEGG Pathway" }, { "url": "https://www.rcsb.org/structure/2DIS", "id": "2DIS", "database": "PDB" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163694", "id": "ENSG00000163694", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/ARMSNDS/", "id": "ARMSNDS", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12491", "id": "cd12491", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12497", "id": "cd12497", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "id": "IPR035979", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "id": "IPR000504", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006535", "id": "IPR006535", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034442", "id": "IPR034442", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034440", "id": "IPR034440", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034445", "id": "IPR034445", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "id": "IPR012677", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00076", "id": "PF00076", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21245:SF6", "id": "PTHR21245:SF6", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0AV96", "id": "PR_A0AV96", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0AV96*", "id": "A0AV96", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/54502", "id": "54502", "database": "GeneID" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0AV96", "id": "A0AV96", "database": "BioXpress" } ] } ], "uniprot_ac": "A0AV96", "disease": [], "mass": { "monoisotopic_mass": 64099.0, "chemical_mass": 64099.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=hsa:54502", "id": "hsa:54502", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0AV96", "name": "RBM47; NET18.", "locus": { "end_pos": 40423267, "start_pos": 40630875, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000163694", "id": "ENSG00000163694", "database": "Ensembl Gene" } ] } } ] }