{
    "uniprot_canonical_ac": "A0A0G2K366-1", 
    "sequence": {
        "header": "tr|A0A0G2K366-1|A0A0G2K366_RAT Isoform 1 of Ribosomal protein S6 kinase  OS=Rattus norvegicus OX=10116 GN=Rps6ka5 PE=1 SV=1 CANONICAL=A0A0G2K366-1", 
        "length": 798, 
        "sequence": "MEGEGGGSGGAGTSGDSGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADEAERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQGMSSVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSERLFQGYSFVAPSILFKRNAAVIDPLQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQKEITALKLCEGHPNVVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKRTSTSTETRSSSSESSRSSSSHSHGKTTPTKTLQPSNPTEGSNPDTLFQFSD"
    }, 
    "uniprot_id": "A0A0G2K366_RAT", 
    "enzyme_annotation": [
        {
            "ec": "2.7.11.1", 
            "activity": "ATP + a protein = ADP + a phosphoprotein."
        }, 
        {
            "ec": "2.7.11.1", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "ribosomal protein S6 kinase alpha-5 isoform X1"
            ], 
            "uniprotkb": [
                "Ribosomal protein S6 kinase", 
                "2.7.11.1"
            ]
        }, 
        "gene": {
            "refseq": [
                "Rps6ka5", 
                "Msk1"
            ], 
            "uniprotkb": [
                "Rps6ka5", 
                "Msk1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                    "id": "A0A0G2K366", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Ribosomal protein S6 kinase; 2.7.11.1."
    }, 
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                    "id": "A0A0G2K366", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012", 
            "pmid": "22673903"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K366#A0A0G2K366-1", 
            "isoform_ac": "A0A0G2K366-1", 
            "locus": {
                "end_pos": 124560861, 
                "start_pos": 124735593, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000091693", 
                        "id": "ENSRNOT00000091693", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072518", 
                        "id": "ENSRNOP00000072518", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2K366-1|A0A0G2K366_RAT Isoform 1 of Ribosomal protein S6 kinase  OS=Rattus norvegicus OX=10116 GN=Rps6ka5 PE=1 SV=1 CANONICAL=A0A0G2K366-1", 
                "length": 798, 
                "sequence": "MEGEGGGSGGAGTSGDSGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADEAERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQGMSSVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSERLFQGYSFVAPSILFKRNAAVIDPLQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQKEITALKLCEGHPNVVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKRTSTSTETRSSSSESSRSSSSHSHGKTTPTKTLQPSNPTEGSNPDTLFQFSD"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K366#D3ZY17-1", 
            "isoform_ac": "D3ZY17-1", 
            "locus": {
                "end_pos": 124567479, 
                "start_pos": 124735593, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000064716", 
                        "id": "ENSRNOT00000064716", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000063163", 
                        "id": "ENSRNOP00000063163", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|D3ZY17-1|A0A0G2K366_RAT Computationally mapped isoform of Ribosomal protein S6 kinase  OS=Rattus norvegicus OX=10116 GN=Rps6ka5 PE=1 SV=1 CANONICAL=A0A0G2K366-1", 
                "length": 518, 
                "sequence": "MEGEGGGSGGAGTSGDSGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADEAERAYSFCGTIEYMAPDIVRGGDSGHDKGMSSVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSERLFQGYSFVAPSILFKRNAAVIDPLQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQKEITALKLCEGHPNVVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPETVFHREISRSPVISMRI"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5621575", 
            "resource": "Reactome", 
            "id": "R-RNO-5621575", 
            "name": "CD209 (DC-SIGN) signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198753", 
            "resource": "Reactome", 
            "id": "R-RNO-198753", 
            "name": "ERK/MAPK targets"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-375165", 
            "resource": "Reactome", 
            "id": "R-RNO-375165", 
            "name": "NCAM signaling for neurite out-growth"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-199920", 
            "resource": "Reactome", 
            "id": "R-RNO-199920", 
            "name": "CREB phosphorylation"
        }
    ], 
    "function": [], 
    "orthologs": [], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240499.1", 
        "ac": "XP_006240499.1", 
        "name": "ribosomal protein S6 kinase alpha-5 isoform X1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein serine/threonine kinase activity", 
                        "id": "GO:0004674"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "magnesium ion binding", 
                        "id": "GO:0000287"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein phosphorylation", 
                        "id": "GO:0006468"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular signal transduction", 
                        "id": "GO:0035556"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070498", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "interleukin-1-mediated signaling pathway", 
                        "id": "GO:0070498"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043987", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H3-S10 phosphorylation", 
                        "id": "GO:0043987"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051092", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of NF-kappaB transcription factor activity", 
                        "id": "GO:0051092"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription, DNA-templated", 
                        "id": "GO:0045892"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035066", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of histone acetylation", 
                        "id": "GO:0035066"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033129", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of histone phosphorylation", 
                        "id": "GO:0033129"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043990", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H2A-S1 phosphorylation", 
                        "id": "GO:0043990"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043988", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
                                "id": "A0A0G2K366", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "histone H3-S28 phosphorylation", 
                        "id": "GO:0043988"
                    }
                ], 
                "total": 11, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 37, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 35
        }, 
        {
            "end_pos": 656, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 654
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240499.1", 
            "id": "XP_006240499.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5621575", 
            "id": "R-RNO-5621575", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198753", 
            "id": "R-RNO-198753", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-375165", 
            "id": "R-RNO-375165", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-199920", 
            "id": "R-RNO-199920", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004362", 
            "id": "ENSRNOG00000004362", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PFHARSR/", 
            "id": "PFHARSR", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016239", 
            "id": "IPR016239", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", 
            "id": "IPR000719", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", 
            "id": "IPR011009", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", 
            "id": "IPR017441", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", 
            "id": "IPR008271", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000961", 
            "id": "IPR000961", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017892", 
            "id": "IPR017892", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00069", 
            "id": "PF00069", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00433", 
            "id": "PF00433", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/314384", 
            "id": "314384", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308336", 
            "id": "1308336", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A0A0G2K366", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 89352.0, 
        "chemical_mass": 89352.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K366", 
            "name": "Rps6ka5; Msk1.", 
            "locus": {
                "end_pos": 124557913, 
                "start_pos": 124735778, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000004362", 
                        "id": "ENSRNOG00000004362", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}