{ "uniprot_canonical_ac": "A0A0G2JTY4-1", "sequence": { "header": "tr|A0A0G2JTY4-1|A0A0G2JTY4_RAT Isoform 1 of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1", "length": 1076, "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ" }, "uniprot_id": "A0A0G2JTY4_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "nuclear factor of activated T-cells, cytoplasmic 3 isoform X3" ], "uniprotkb": [ "Nuclear factor of-activated T-cells 3", "Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b" ] }, "gene": { "refseq": [ "Nfatc3", "NFAT4" ], "uniprotkb": [ "Nfatc3", "Nfatc3_predicted", "rCG_51043", "NFAT4" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Nuclear factor of-activated T-cells 3; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#A0A0G2JTY4-1", "isoform_ac": "A0A0G2JTY4-1", "locus": { "end_pos": 38039810, "start_pos": 38111461, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087491", "id": "ENSRNOT00000087491", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068890", "id": "ENSRNOP00000068890", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTY4-1|A0A0G2JTY4_RAT Isoform 1 of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1", "length": 1076, "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#D3ZU59-1", "isoform_ac": "D3ZU59-1", "locus": { "end_pos": 38039810, "start_pos": 38100739, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089783", "id": "ENSRNOT00000089783", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069756", "id": "ENSRNOP00000069756", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZU59-1|A0A0G2JTY4_RAT Computationally mapped isoform of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1", "length": 1068, "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDDQFMSDLEHQPSGSTEKWPNHSEFSCPVPFWRI" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2025928", "resource": "Reactome", "id": "R-RNO-2025928", "name": "Calcineurin activates NFAT" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "resource": "Reactome", "id": "R-RNO-2871809", "name": "FCERI mediated Ca+2 mobilization" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607763", "resource": "Reactome", "id": "R-RNO-5607763", "name": "CLEC7A (Dectin-1) induces NFAT activation" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q12968-1", "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 3; NF-ATc3; NFATc3; NFATx; T-cell transcription factor NFAT4; NF-AT4; NF-AT4c.", "sequence": { "length": 1075, "sequence": "MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/27827", "id": "27827", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/795278/", "id": "795278", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255575.1", "ac": "XP_006255575.1", "name": "nuclear factor of activated T-cells, cytoplasmic 3 isoform X3.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044798", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "nuclear transcription factor complex", "id": "GO:0044798" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "transcription factor complex", "id": "GO:0005667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001816", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "cytokine production", "id": "GO:0001816" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033173", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "calcineurin-NFAT signaling cascade", "id": "GO:0033173" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "negative regulation of vascular smooth muscle cell differentiation", "id": "GO:1905064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4", "database": "UniProtKB" } ], "name": "negative regulation of pri-miRNA transcription by RNA polymerase II", "id": "GO:1902894" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 59, "annotation": "n_glycosylation_sequon", "start_pos": 57 }, { "end_pos": 533, "annotation": "n_glycosylation_sequon", "start_pos": 531 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255575.1", "id": "XP_006255575.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2025928", "id": "R-RNO-2025928", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "id": "R-RNO-2871809", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607763", "id": "R-RNO-5607763", "database": "Reactome" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054264", "id": "ENSRNOG00000054264", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WPLPSHY/", "id": "WPLPSHY", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "id": "IPR013783", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "id": "IPR014756", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "id": "IPR032397", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "id": "IPR008967", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008366", "id": "IPR008366", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "id": "IPR011539", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "id": "IPR037059", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "id": "IPR002909", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF16179", "id": "PF16179", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00554", "id": "PF00554", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533", "id": "PTHR12533", "database": "PANTHER" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/361400", "id": "361400", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308692", "id": "1308692", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A0A0G2JTY4", "disease": [], "mass": { "monoisotopic_mass": 115656.0, "chemical_mass": 115656.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "name": "Nfatc3; Nfatc3_predicted; rCG_51043; NFAT4.", "locus": { "end_pos": 38114003, "start_pos": 38039564, "chromosome": "19", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000054264", "id": "ENSRNOG00000054264", "database": "Ensembl Gene" } ] } } ] }