{ "uniprot_canonical_ac": "A2RT60-1", "sequence": { "header": "sp|A2RT60-1|HTRA4_MOUSE Isoform 1 of Serine protease HTRA4 OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1 CANONICAL=A2RT60-1", "length": 483, "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN" }, "uniprot_id": "HTRA4_MOUSE", "enzyme_annotation": [ { "ec": "3.4.21.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "serine protease HTRA4 precursor", "high-temperature requirement factor A4; serine protease HTRA4" ], "uniprotkb": [ "Serine protease HTRA4", "3.4.21.-", "High-temperature requirement factor A4" ] }, "gene": { "refseq": [ "Htra4", "B430206E18Rik" ], "uniprotkb": [ "Htra4", "B430206E18Rik" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "id": "A2RT60", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Serine protease HTRA4; 3.4.21.-; High-temperature requirement factor A4." }, "publication": [ { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "id": "NP_001074656.1", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "Generation and characterization of mice with a conditional null allele of the HtrA4 gene.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26353049", "journal": "Molecular medicine reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "id": "NP_001074656.1", "database": "RefSeq" } ], "authors": "Liu J, Li Y, Hoh J", "date": "2015", "pmid": "26353049" }, { "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "id": "NP_001074656.1", "database": "RefSeq" } ], "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", "date": "2014", "pmid": "24194600" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RT60#A2RT60-1", "isoform_ac": "A2RT60-1", "locus": { "end_pos": 25025572, "start_pos": 25038874, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000084031", "id": "ENSMUST00000084031", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000081044", "id": "ENSMUSP00000081044", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RT60-1|HTRA4_MOUSE Isoform 1 of Serine protease HTRA4 OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1 CANONICAL=A2RT60-1", "length": 483, "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:330723", "resource": "KEGG Pathway", "id": "mmu:330723", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RT60#function", "annotation": "Serine protease.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60#function", "id": "A2RT60", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "annotation": "Mice, featuring a conditional null allele of HtrA4, may provide a valuable tool to investigate the role of HtrA4 in development and pathogenesis of coronary heart disease and preeclampsia.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "id": "NP_001074656.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZKF5-1", "protein_name": "Serine protease HTR4; 3.4.21.-; High-temperature requirement factor A4.", "sequence": { "length": 488, "sequence": "MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPCPDACDPTRCPPLPSCSAGSALVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPFSREPSGRAWLGTCGCAEGAEGAAVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACGDSGTTRAGRLRTKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDHKLDLALIKIEPDTDLPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/17801", "id": "17801", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "P83105-1", "protein_name": "Serine protease HTRA4; 3.4.21.-; High-temperature requirement factor A4.", "sequence": { "length": 476, "sequence": "MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/551588/", "id": "551588", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/17801", "id": "17801", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "ac": "NP_001074656.1", "name": "serine protease HTRA4 precursor; high-temperature requirement factor A4; serine protease HTRA4.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "id": "A2RT60", "database": "UniProtKB" } ], "name": "endopeptidase activity", "id": "GO:0004175" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "id": "A2RT60", "database": "UniProtKB" } ], "name": "serine-type endopeptidase activity", "id": "GO:0004252" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "id": "A2RT60", "database": "UniProtKB" } ], "name": "insulin-like growth factor binding", "id": "GO:0005520" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "id": "A2RT60", "database": "UniProtKB" } ], "name": "extracellular region", "id": "GO:0005576" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "id": "A2RT60", "database": "UniProtKB" } ], "name": "proteolysis", "id": "GO:0006508" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", "id": "NP_001074656.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:330723", "id": "mmu:330723", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037406", "id": "ENSMUSG00000037406", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/NQQWIEV/", "id": "NQQWIEV", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "id": "IPR009030", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "id": "IPR036058", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "id": "IPR001478", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "id": "IPR009003", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "id": "IPR036034", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "id": "IPR002350", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867", "id": "IPR000867", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001940", "id": "IPR001940", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041489", "id": "IPR041489", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF07648", "id": "PF07648", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00219", "id": "PF00219", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17820", "id": "PF17820", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RT60", "id": "PR_A2RT60", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/330723", "id": "330723", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3036260", "id": "3036260", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2RT60", "disease": [], "mass": { "monoisotopic_mass": 51988.0, "chemical_mass": 51988.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RT60", "name": "Htra4; B430206E18Rik.", "locus": { "end_pos": 25024929, "start_pos": 25038962, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000037406", "id": "ENSMUSG00000037406", "database": "Ensembl Gene" } ] } } ] }